In the Model Cell Lines of Moderately and Poorly Differentiated Endometrial Carcinoma, Estrogens Can Be Formed via the Sulfatase Pathway

Autor: Renata Pavlič, Marija Gjorgoska, Eva Hafner, Maša Sinreih, Kristina Gajser, Stefan Poschner, Walter Jäger, Tea Lanišnik Rižner

Publikováno v: Frontiers in Molecular Biosciences, Vol 8 (2021)

Endometrial cancer (EC) is the most common gynecological malignancy in resource-abundant countries. The majority of EC cases are estrogen dependent but the mechanisms of estrogen biosynthesis and oxidative metabolism and estrogen action are not compl

Externí odkaz: https://doaj.org/article/6336b51297f74a35b21700fe0aaeb502

Data on expression of genes involved in estrogen and progesterone action, inflammation and differentiation according to demographic, histopathological and clinical characteristics of endometrial cancer patients

Autor: Maša Sinreih, Saša Štupar, Luka Čemažar, Ivan Verdenik, Snježana Frković Grazio, Špela Smrkolj, Tea Lanišnik Rižner

Publikováno v: Data in Brief, Vol 12, Iss C, Pp 632-643 (2017)

Endometrial cancer is the sixth most common cancer in women worldwide. It is associated with aberrant actions of steroid hormones, estrogens and progesterone, but also with enhanced inflammation and reduced cellular differentiation. Here, we show dat

Externí odkaz: https://doaj.org/article/7463ebab383f42fdb5e33dec74cd8fec

Synthesis and evaluation of AKR1C inhibitory properties of A-ring halogenated oestrone derivatives

Autor: Tomaž Büdefeld, Maša Sinreih, Zoltán Kele, Rebeka Jójárt, Gábor Paragi, Erzsébet Mernyák, Tea Lanišnik Rižner

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of enzyme inhibition and medicinal chemistry, vol. 36, no. 1, 2021.
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1499-1507 (2021)

Enzymes AKR1C regulate the action of oestrogens, androgens, and progesterone at the pre-receptor level and are also associated with chemo-resistance. The activities of these oestrone halides were investigated on recombinant AKR1C enzymes. The oestron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b42d48b20bc92ffdd8af2ec4f7be423
http://europepmc.org/articles/PMC8266253

N ‐Phenyl‐1,2,3,4‐tetrahydroisoquinoline: An Alternative Scaffold for the Design of 17β‐Hydroxysteroid Dehydrogenase 1 Inhibitors

Autor: Marco Mottinelli, Mathew P. Leese, Tea Lanišnik Rižner, Barry V. L. Potter, Maša Sinreih

Publikováno v: Potter, B, Mottinelli, M & Leese, M P 2021, ' N-Phenyl-1,2,3,4-tetrahydroisoquinoline: an alternative scaffold for design of 17-hydroxysteroid dehydrogenase 1 inhibitors ', ChemMedChem, vol. 16, no. 1, pp. 259-291 . https://doi.org/10.1002/cmdc.202000762

17β‐Hydroxysteroid dehydrogenases act at the pre‐receptor level, catalysing interconversion at the C17 position between oxidized and reduced forms of steroidal nuclear receptor ligands. The type 1 enzyme, expressed in malignant cells, catalyses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76403185a747b5db1b1652df15b7eb65
https://doi.org/10.1002/cmdc.202000762

The Co-Expression of Estrogen Receptors ERα, ERβ, and GPER in Endometrial Cancer

Autor: Marko Hojnik, Maša Sinreih, Maja Anko, Neli Hevir-Kene, Tamara Knific, Boštjan Pirš, Snježana Frković Grazio, Tea Lanišnik Rižner

Publikováno v: International Journal of Molecular Sciences. 24:3009

Estrogens have important roles in endometrial cancer (EC) and exert biological effects through the classical estrogen receptors (ERs) ERα and ERβ, and the G-protein–coupled ER, GPER. So far, the co-expression of these three types of ERs has not b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2610df488f811fe534aed1f5445cf16
https://doi.org/10.3390/ijms24033009