Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Małgorzata Zygmunt"'
Autor:
Aneta Kaczor, Joanna Knutelska, Katarzyna Kucwaj-Brysz, Małgorzata Zygmunt, Ewa Żesławska, Agata Siwek, Marek Bednarski, Sabina Podlewska, Magdalena Jastrzębska-Więsek, Wojciech Nitek, Jacek Sapa, Jadwiga Handzlik
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 16609 (2023)
In order to find new hypotensive drugs possessing higher activity and better selectivity, a new series of fifteen 5,5-dimethylhydantoin derivatives (1–15) was designed. Three-step syntheses, consisting of N-alkylations using standard procedures as
Externí odkaz:
https://doaj.org/article/cee6fa445dd2407ca81ed8f23a1464ab
Autor:
Michał Załuski, Dorota Łażewska, Piotr Jaśko, Ewelina Honkisz-Orzechowska, Kamil J. Kuder, Andreas Brockmann, Gniewomir Latacz, Małgorzata Zygmunt, Maria Kaleta, Beril Anita Greser, Agnieszka Olejarz-Maciej, Magdalena Jastrzębska-Więsek, Christin Vielmuth, Christa E. Müller, Katarzyna Kieć-Kononowicz
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 13707 (2023)
Chronic inflammation plays an important role in the development of neurodegenerative diseases, such as Parkinson’s disease (PD). In the present study, we synthesized 25 novel xanthine derivatives with variable substituents at the N1-, N3- and C8-po
Externí odkaz:
https://doaj.org/article/5963438b8d354c9ba124160cee724d87
Autor:
Adrian Bryla, Małgorzata Zygmunt, Krystyna Chmal-Jagiełło, Paweł Węgrzyn, Michał Steczko, Tomasz Buczek
Publikováno v:
Farmacja Polska, Vol 77, Iss 4, Pp 235-240 (2021)
Fluid treatment is one of the basic medical procedures used in every hospital. To be properly conducted, it requires making complex decisions regarding the optimal volume, infusion rate, and type of fluids. Fluid therapy should only be used in patien
Externí odkaz:
https://doaj.org/article/65e9726f138c4cda832f7deb5c478c48
Autor:
Magdalena Kotańska, Anna Dziubina, Małgorzata Szafarz, Kamil Mika, Karolina Reguła, Marek Bednarski, Małgorzata Zygmunt, Anna Drabczyńska, Jacek Sapa, Katarzyna Kieć-Kononowicz
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0229806 (2020)
The A2 adenosine receptors play an important role, among others, in the regulation of inflammatory process and glucose homeostasis in diabetes and obesity. Thus, the presented project evaluated of influence of the selective antagonist of A2A adenosin
Externí odkaz:
https://doaj.org/article/2d0c6a2ccf8848c79ffcb34e1aaa30e1
Autor:
Dorota Łażewska, Agnieszka Olejarz-Maciej, David Reiner, Maria Kaleta, Gniewomir Latacz, Małgorzata Zygmunt, Agata Doroz-Płonka, Tadeusz Karcz, Annika Frank, Holger Stark, Katarzyna Kieć-Kononowicz
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 10, p 3411 (2020)
Dual target ligands are a promising concept for the treatment of Parkinson’s disease (PD). A combination of monoamine oxidase B (MAO B) inhibition with histamine H3 receptor (H3R) antagonism could have positive effects on dopamine regulation. Thus,
Externí odkaz:
https://doaj.org/article/f371b77591264303979d688b00fac771
Autor:
Karolina Pytka, Klaudia Lustyk, Elżbieta Żmudzka, Magdalena Kotańska, Agata Siwek, Małgorzata Zygmunt, Agnieszka Dziedziczak, Joanna Śniecikowska, Adrian Olczyk, Adam Gałuszka, Jarosław Śmieja, Anna Maria Waszkielewicz, Henryk Marona, Barbara Filipek, Jacek Sapa, Szczepan Mogilski
Publikováno v:
Frontiers in Pharmacology, Vol 7 (2016)
Studies proved that among all α1-adrenoceptors, cardiac myocytes functionally express only α1A- and α1B-subtype. Scientists indicated that α1A-subtype blockade might be beneficial in restoring normal heart rhythm. Therefore, we aimed to determine
Externí odkaz:
https://doaj.org/article/f6d6d09f1b984a7ca25590e6c5801f96
Autor:
Vittorio Canale, Aleksandra Rak, Magdalena Kotańska, Joanna Knutelska, Agata Siwek, Marek Bednarski, Leszek Nowiński, Małgorzata Zygmunt, Paulina Koczurkiewicz, Elżbieta Pękala, Jacek Sapa, Paweł Zajdel
Publikováno v:
Molecules, Vol 23, Iss 9, p 2175 (2018)
Benign prostatic hyperplasia (BPH) is the most common male clinical problem impacting the quality of life of older men. Clinical studies have indicated that the inhibition of α1A-/α1D adrenoceptors might offer effective therapy in lower urinary tra
Externí odkaz:
https://doaj.org/article/92168b24298f44cd87e127c4ecdf3793
Autor:
Magdalena Dudek, Joanna Knutelska, Marek Bednarski, Leszek Nowiński, Małgorzata Zygmunt, Barbara Mordyl, Monika Głuch-Lutwin, Grzegorz Kazek, Jacek Sapa, Karolina Pytka
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141327 (2015)
The search for drugs with anorectic activity, acting within the adrenergic system has attracted the interest of researchers. Partial α2-adrenoceptor agonists might offer the potential for effective and safe treatment of obesity. We compared the effe
Externí odkaz:
https://doaj.org/article/7c72d98cccff4ce99d65fbc8830de184
Autor:
Krystyna Chmal-Jagiełło, Tomasz Buczek, Paweł Węgrzyn, Adrian Bryła, Michał Steczko, Małgorzata Zygmunt
Publikováno v:
Farmacja Polska, Vol 77, Iss 4, Pp 235-240 (2021)
Fluid treatment is one of the basic medical procedures used in every hospital. To be properly conducted, it requires making complex decisions regarding the optimal volume, infusion rate, and type of fluids. Fluid therapy should only be used in patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06595f373fe5658107364ebbecf916b9
Autor:
Małgorzata Zygmunt, Marietta Ślusarczyk, Agnieszka Jankowska, Artur Świerczek, Adrian Bryła, Szczepan Mogilski, Grzegorz Kazek, Jacek Sapa, Elżbieta Wyska, Grażyna Chłoń-Rzepa
BackgroundTo verify the validity of the proposed pain treatment approach, which is based on concomitant blocking of the Transient Receptor Potential Ankyrin 1 (TRPA1) channel and phosphodiesterases (PDEs) 4B/7A activity, we continued our pharmacologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de2c7fb7310db6c5b7ab4d7c41a3ab8f
https://ruj.uj.edu.pl/xmlui/handle/item/298315
https://ruj.uj.edu.pl/xmlui/handle/item/298315
