Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Małgorzata Sierant"'
Autor:
Anastasiia Bohush, Agnieszka Góral, Małgorzata Sierant, Barbara Nawrot, Wiesława Leśniak, Anna Filipek
Publikováno v:
Biomolecules, Vol 11, Iss 11, p 1675 (2021)
The SGT1 protein is highly expressed in the mammalian brain, particularly in neurons of the hippocampus and cortex, and in Purkinje cells of the cerebellum. There are literature data indicating that the protein may be involved in pathogenesis of neur
Externí odkaz:
https://doaj.org/article/548af5e5c60744fcb107787e249addc7
Autor:
Patrycja Szczupak, Ewa Radzikowska-Cieciura, Katarzyna Kulik, Rafał Madaj, Małgorzata Sierant, Agnieszka Krakowiak, Barbara Nawrot
Publikováno v:
Bioorganic chemistry. 122
Bacterial tRNA 2-selenouridine synthase (SelU) in vitro converts S2U-RNA to its selenium analog (Se2U-RNA) in a two-step process: (i) geranylation of S2U-RNA (with geranyl pyrophosphate, gePP), and (ii) selenation of the resulting geS2U-RNA (with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5da16607edaf7c4606c4b12a98be46d
https://pubmed.ncbi.nlm.nih.gov/35306417
https://pubmed.ncbi.nlm.nih.gov/35306417
Autor:
Patrycja Szczupak, Malgorzata Sierant, Ewelina Wielgus, Ewa Radzikowska-Cieciura, Katarzyna Kulik, Agnieszka Krakowiak, Paulina Kuwerska, Grazyna Leszczynska, Barbara Nawrot
Publikováno v:
Cells, Vol 11, Iss 9, p 1522 (2022)
The bacterial enzyme tRNA 2-selenouridine synthase (SelU) is responsible for the conversion of 5-substituted 2-thiouridine (R5S2U), present in the anticodon of some bacterial tRNAs, into 5-substituted 2-selenouridine (R5Se2U). We have already demonst
Externí odkaz:
https://doaj.org/article/3aeb9907943547ef934c4e0aa8fd7698
Autor:
Malgorzata Sierant, Alina Paduszynska, Julia Kazmierczak-Baranska, Benedetta Nacmias, Sandro Sorbi, Silvia Bagnoli, Elzbieta Sochacka, Barbara Nawrot
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2011 (2011)
RNA interference (RNAi) technology provides a powerful molecular tool to reduce an expression of selected genes in eukaryotic cells. Short interfering RNAs (siRNAs) are the effector molecules that trigger RNAi. Here, we describe siRNAs that discrimin
Externí odkaz:
https://doaj.org/article/7841cbfde3bb4d1499e7be03e5add5c8
Autor:
Malgorzata Sierant, Katarzyna Kubiak, Julia Kazmierczak-Baranska, Masaki Warashina, Tomoko Kuwabara, Barbara Nawrot
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2009 (2009)
Beta-secretase (BACE1) is the major enzyme participating in generation of toxic amyloid-beta (Aβ) peptides, identified in amyloid plaques of Alzheimer's disease (AD) brains. Its downregulation results in decreasing secretion of Aβ. Thus, BACE1 sile
Externí odkaz:
https://doaj.org/article/5aef3d218fcd42229f5e5825c6ba60d8