Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Małgorzata Ryczkowska"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract A new method for the preparation of tetrahydroquinolin-2-one derivatives is presented. This approach involves a two-step reaction between enaminones and acylating agents, immediately followed by electrophilic cyclization, all within a single
Externí odkaz:
https://doaj.org/article/ae4085ffb5454e56ae3b450b0674622f
Autor:
Małgorzata Ryczkowska, Natalia Maciejewska, Mateusz Olszewski, Milena Witkowska, Sławomir Makowiec
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The anticancer properties of quinolones is a topic of interest among researchers in the scientific world. Because these compounds do not cause side effects, unlike the commonly used cytostatics, they are considered a promising source of new
Externí odkaz:
https://doaj.org/article/e14121f0571f4930bf5c2ae8b0ece9d0
Autor:
Małgorzata Ryczkowska, Natalia Maciejewska, Mateusz Olszewski, Milena Witkowska, Sławomir Makowiec
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Colorectal cancer (CRC) is the most commonly diagnosed cancer in Europe and the United States and the second leading cause of cancer related mortality. A therapeutic strategy used for the treatment of CRC involves targeting the intracellular
Externí odkaz:
https://doaj.org/article/fb224a41963143b185f729852d6f25eb
Autor:
Małgorzata Ryczkowska, Natalia Maciejewska, Mateusz Olszewski, Milena Witkowska, Sławomir Makowiec
Colorectal cancer (CRC) is the most commonly diagnosed cancer in Europe and the United States and the second leading cause of cancer related mortality. A therapeutic strategy used for the treatment of CRC involves targeting the intracellular levels o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0b2f58480f4a6b927f73f3b2f941403
https://doi.org/10.21203/rs.3.rs-1497725/v1
https://doi.org/10.21203/rs.3.rs-1497725/v1
Publikováno v:
Synthesis. 51:4625-4634
Herein, we describe the synthesis of a 1,2,4-trisubstituted carbazole core from 5-(1H-indol-3-yl)-3-oxopentanoic acid esters or amides. For oxidative cyclization, we tested two different approaches. First, we used manganese triacetate as a convention
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e3791406851f3ad1923b25bf28dff9a
https://doi.org/10.1055/s-0039-1690681
https://doi.org/10.1055/s-0039-1690681
Autor:
Milena Witkowska, Natalia Maciejewska, Małgorzata Ryczkowska, Mateusz Olszewski, Maciej Bagiński, Sławomir Makowiec
Publikováno v:
European Journal of Medicinal Chemistry. 238:114453
Mitochondrial targeting plays an important role in anticancer therapy. The Mn(III)-promoted cyclization of 5-(1H-indol-3-yl)-3-oxopentanoic acid allow to obtain novel substituted carbazole derivatives that can act as mitochondria-disruptive agents. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c203a75cbe3682685a2db4375f66d8d
https://doi.org/10.1016/j.ejmech.2022.114453
https://doi.org/10.1016/j.ejmech.2022.114453