Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Małgorzata Jarończyk"'
Publikováno v:
Molecules, Vol 28, Iss 15, p 5684 (2023)
The structure, energetics, and aromaticity of c.a. 100 constitutional isomers and tautomers of pyrido[m,n]diazepines (m = 1, 2; n = 2, 3, 4, 5; m ≠ n) were studied at the B3LYP/cc-pVTZ level. The pyrido[1,3]diazepines appear the most, while pyrido[
Externí odkaz:
https://doaj.org/article/97faee81198e4ec68fe28ccc244d0130
Autor:
Małgorzata Jarończyk, Jarosław Walory
Publikováno v:
Molecules, Vol 27, Iss 2, p 533 (2022)
Antidepressants target a variety of proteins in the central nervous system (CNS), the most important belonging to the family of G-protein coupled receptors and the family of neurotransmitter transporters. The increasing number of crystallographic str
Externí odkaz:
https://doaj.org/article/d888e3dc17164b4aacd294af3b32c4bd
Publikováno v:
Molecules, Vol 25, Iss 7, p 1753 (2020)
Cancers are the leading cause of deaths worldwide. In 2018, an estimated 18.1 million new cancer cases and 9.6 million cancer-related deaths occurred globally. Several previous studies have shown that the enzyme, leucine aminopeptidase is involved in
Externí odkaz:
https://doaj.org/article/ee96ff3128f248d7a3a8083b51e1e784
Autor:
Piotr F. J. Lipiński, Piotr Kosson, Joanna Matalińska, Piotr Roszkowski, Zbigniew Czarnocki, Małgorzata Jarończyk, Aleksandra Misicka, Jan Cz. Dobrowolski, Joanna Sadlej
Publikováno v:
Molecules, Vol 24, Iss 4, p 740 (2019)
Interactions of 21 fentanyl derivatives with μ-opioid receptor (μOR) were studied using experimental and theoretical methods. Their binding to μOR was assessed with radioligand competitive binding assay. A uniform set of binding affinity data cont
Externí odkaz:
https://doaj.org/article/d0d92795855649f1a53b628ab3091545
Autor:
Mateusz Kurciński, Małgorzata Jarończyk, Piotr F. J. Lipiński, Jan Cz. Dobrowolski, Joanna Sadlej
Publikováno v:
Molecules, Vol 23, Iss 2, p 456 (2018)
Despite considerable advances over the past years in understanding the mechanisms of action and the role of the σ1 receptor, several questions regarding this receptor remain unanswered. This receptor has been identified as a useful target for the tr
Externí odkaz:
https://doaj.org/article/a8cc631e453c485dbca12a854848f402
Autor:
Anna Wajda, Barbara Stypińska, Magdalena Czarnecka, Diana Hasan, Małgorzata Jarończyk, Ewa Haładyj, Katarzyna Romanowska-Próchnicka, Marzena Olesińska, Andrzej Pawlik, Agnieszka Paradowska-Gorycka
Publikováno v:
Clinical and experimental rheumatology.
SMADs play one of the key roles in the TGFβ signalling pathway. Therefore, through their involvement in the immune response as well as in the fibrosis process, these proteins appear to take on one of the essential functions in the pathogenesis of au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36bf00019d7eb109337e8a765c8cca3d
https://pubmed.ncbi.nlm.nih.gov/36377587
https://pubmed.ncbi.nlm.nih.gov/36377587
Autor:
Edina Szűcs, Jan Cz. Dobrowolski, Sándor Benyhe, Piotr Kosson, Aleksandra Misicka, Małgorzata Jarończyk, Joanna Sadlej, Piotr F. J. Lipiński
Publikováno v:
Treatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6dac0bae2131ececa592d8ee0606524
https://doi.org/10.1016/b978-0-12-820237-1.00010-7
https://doi.org/10.1016/b978-0-12-820237-1.00010-7
Autor:
Małgorzata Jarończyk, Jarosław Walory
Publikováno v:
Molecules
Molecules, Vol 27, Iss 533, p 533 (2022)
Molecules, Vol 27, Iss 533, p 533 (2022)
Antidepressants target a variety of proteins in the central nervous system (CNS), the most important belonging to the family of G-protein coupled receptors and the family of neurotransmitter transporters. The increasing number of crystallographic str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeee219fd0baefe25418694a3f39ef04
https://pubmed.ncbi.nlm.nih.gov/35056845
https://pubmed.ncbi.nlm.nih.gov/35056845
Publikováno v:
Chemical Papers. 71:2557-2568
Here, we report a theoretical study on leucine aminopeptidase (LAP) inhibitors. 3D quantitative structure–activity relationship (3D-QSAR) studies were carried out on a series of known substituted dihydroisoquinoline derivatives and other chemical c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::174f03bf63471eac000833d6c7b04d35
https://doi.org/10.1007/s11696-017-0251-3
https://doi.org/10.1007/s11696-017-0251-3
Publikováno v:
Chemical Papers. 71:1429-1443
Fentanyl is a synthetic opioid analgesic used as a pain reliever and an anaesthetic. Minor differences in the substituent on the N-phenylethyl or the N-phenylpropanamide groups may be a contributing factor in reducing or increasing the affinity of it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::428370f2cc449e00af37600ddb84a547
https://doi.org/10.1007/s11696-017-0136-5
https://doi.org/10.1007/s11696-017-0136-5