Molecular pattern of a decrease in the rewarding effect of cocaine after an escalating-dose drug regimen

Autor: Karolina, Kołosowska, Małgorzata, Lehner, Anna, Skórzewska, Aleksandra, Gawryluk, Filip, Tomczuk, Alicja, Sobolewska, Danuta, Turzyńska, Monika, Liguz-Lęcznar, Małgorzata, Bednarska-Makaruk, Piotr, Maciejak, Aleksandra, Wisłowska-Stanek

Publikováno v: Pharmacological Reports. 75:85-98

Background Long-term cocaine exposure leads to dysregulation of the reward system and initiates processes that ultimately weaken its rewarding effects. Here, we studied the influence of an escalating-dose cocaine regimen on drug-associated appetitive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6336f5d20224161bde3df42e7ba12af
https://doi.org/10.1007/s43440-022-00443-3

Sex-Related Predisposition to Post-Traumatic Stress Disorder Development—The Role of Neuropeptides

Autor: Małgorzata Lehner, Anna Skórzewska, Aleksandra Wisłowska-Stanek

Publikováno v: International Journal of Environmental Research and Public Health, Vol 19, Iss 314, p 314 (2022)
International Journal of Environmental Research and Public Health

Post-traumatic stress disorder (PTSD) is characterized by re-experiencing a traumatic event, avoidance, negative alterations in cognitions and mood, hyperarousal, and severe functional impairment. Women have a two times higher risk of developing PTSD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad90eb2203b5021d357ab031031d9b2
https://www.mdpi.com/1660-4601/19/1/314

The effects of the recurrent social isolation stress on fear extinction and dopamine D

Autor: Aleksandra, Wisłowska-Stanek, Małgorzata, Lehner, Filip, Tomczuk, Aleksandra, Gawryluk, Karolina, Kołosowska, Anna, Sułek, Paweł, Krząśnik, Alicja, Sobolewska, Adriana, Wawer, Adam, Płaźnik, Anna, Skórzewska

Publikováno v: Pharmacological reports : PR.

The present study assessed the influence of recurrent social isolation stress on the aversive memory extinction and dopamine DMale adult fear-conditioned rats had three episodes of 48 h social isolation stress before each fear extinction session in w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ae554c9aea73c308b37183d08af486e6
https://pubmed.ncbi.nlm.nih.gov/36385611

The amphetamine-associated context exerts a stronger motivational effect in low-anxiety rats than in high-anxiety rats

Autor: Aleksandra Wisłowska-Stanek, Alicja Sobolewska, Marek Gryz, Anna Skórzewska, Małgorzata Lehner, Danuta Turzyńska, Adam Płaźnik

Publikováno v: Behavioural Brain Research. 330:97-107

This study used the conditioned place preference test to explore the effects of subchronic amphetamine administration on drug-associated cues in rats with different emotional reactivity. We also examined the changes in markers of dopaminergic activit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a814e8f16c6a1f9d346711a2c6e23e
https://doi.org/10.1016/j.bbr.2017.05.012

Low-anxiety rats are more sensitive to amphetamine in comparison to high-anxiety rats

Autor: Małgorzata Lehner, Adam Płaźnik, Aleksandra Wisłowska-Stanek, Ewa Taracha, Alicja Sobolewska, Danuta Turzyńska, Ewelina Kaniuga, Anna Skórzewska, Marek Gryz

Publikováno v: Journal of Psychopharmacology. 31:115-126

This study utilised the two injection protocol of sensitisation (TIPS) and the conditioned place preference test to validate and extend previous findings on the effects of amphetamine on positive reinforcement-related 50 kHz ultrasonic vocalisation (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303c02e8ea1e689f28e9b7918941ff4a
https://doi.org/10.1177/0269881116667708