Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Mañosas, M."'
Publikováno v:
Int. J. Mol. Sci. 2021, 22(9), 4745
The accurate knowledge of the elastic properties of single-stranded DNA (ssDNA) is key to characterize the thermodynamics of molecular reactions that are studied by force spectroscopy methods where DNA is mechanically unfolded. Examples range from DN
Externí odkaz:
http://arxiv.org/abs/2110.09370
Publikováno v:
Phys.Rev.X 11, 031037 (2021)
The folding of biological macromolecules is a fundamental process of which we lack a full comprehension. Mostly studied in proteins and RNA, single-stranded DNA (ssDNA) also folds, at physiological salt conditions, by forming non-specific secondary s
Externí odkaz:
http://arxiv.org/abs/2109.10829
Publikováno v:
Phys. Rev. X, 2 031012 (2012)
Stochastic resonance (SR) is a well known phenomenon in dynamical systems. It consists of the amplification and optimization of the response of a system assisted by stochastic noise. Here we carry out the first experimental study of SR in single DNA
Externí odkaz:
http://arxiv.org/abs/1212.2269
Publikováno v:
Biophysical Journal, 100 : 1765-1774 (2011)
We investigate unfolding/folding force kinetics in DNA hairpins exhibiting two and three states with newly designed short dsDNA handles (29 bp) using optical tweezers. We show how the higher stiffness of the molecular setup moderately enhances the si
Externí odkaz:
http://arxiv.org/abs/1105.4734
Publikováno v:
Phys.Rev.E78:061925,2008
RNA folding is a kinetic process governed by the competition of a large number of structures stabilized by the transient formation of base pairs that may induce complex folding pathways and the formation of misfolded structures. Despite of its import
Externí odkaz:
http://arxiv.org/abs/0901.4094
Autor:
Wen, J. -D., Manosas, M., Li, P. T. X., Smith, S. B., Bustamante, C., Ritort, F., Tinoco Jr, I.
Publikováno v:
Biophysical Journal, 92 (2007) 2996-3009
Experimental variables of optical tweezers instrumentation that affect RNA folding/unfolding kinetics were investigated. A model RNA hairpin, P5ab, was attached to two micron-sized beads through hybrid RNA/DNA handles; one bead was trapped by dual-be
Externí odkaz:
http://arxiv.org/abs/0707.0580
Autor:
Manosas, M., Wen, J. -D., Li, P. T. X., Smith, S. B., Bustamante, C., Tinoco, Jr., I., Ritort, F.
Publikováno v:
Biophysical Journal, 92 (2007) 3010-3021
By exerting mechanical force it is possible to unfold/refold RNA molecules one at a time. In a small range of forces, an RNA molecule can hop between the folded and the unfolded state with force-dependent kinetic rates. Here, we introduce a mesoscopi
Externí odkaz:
http://arxiv.org/abs/0707.0662
Publikováno v:
Phys. Rev. Lett. vol. 96, 218301 (2006)
We apply Kramers theory to investigate the dissociation of multiple bonds under mechanical force and interpret experimental results for the unfolding/refolding force distributions of an RNA hairpin pulled at different loading rates using laser tweeze
Externí odkaz:
http://arxiv.org/abs/cond-mat/0606254
Autor:
Hodeib, Samar, Raj, Saurabh, Manosas, M., Zhang, Weiting, Bagchi, Debjani, Ducos, Bertrand, Allemand, Jean-François, Bensimon, David, Croquette, Vincent
Publikováno v:
In Methods 1 August 2016 105:3-15
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