Zobrazeno 1 - 10
of 320
pro vyhledávání: '"Ma, Surani"'
Publikováno v:
BMC Developmental Biology
BMC Developmental Biology, Vol 3, Iss 1, p 1 (2003)
BMC Developmental Biology, Vol 3, Iss 1, p 1 (2003)
Background Specification of primordial germ cells in mice depends on instructive signalling events, which act first to confer germ cell competence on epiblast cells, and second, to impose a germ cell fate upon competent precursors. fragilis, an inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1678911da104b711e48fbd667b4e1637
Publikováno v:
Europe PubMed Central
H19 and Igf2 are located within a large imprinting domain that confers monoallelic silencing of parental alleles. The silent paternal allele of H19 is hypermethylated and relatively resistant to nucleases. Using a 130 kb yeast artificial chromosome c
Publikováno v:
Europe PubMed Central
The T-cell oncogene rhombotin was first identified as a gene near a chromosomal translocation breakpoint in a human T-cell tumour and represents the first example of an oncogene carrying the duplicated cysteine-rich regions (CRR or LIM domains). Tran
Publikováno v:
Europe PubMed Central
Genomic imprinting results in a functional non-equivalence of parental chromosomes, presumably by epigenetic modification of the genome, and is required for normal mammalian development. In general, reciprocal phenotypes are observed in embryos conta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a010d329d6154935193bc8081d749865
http://europepmc.org/abstract/med/2101722
http://europepmc.org/abstract/med/2101722
Publikováno v:
Europe PubMed Central
Development in mammals is influenced by genome imprinting which results in differences in the expression of some homologous maternal and paternal alleles. This process, initiated in the germline, can continue following fertilization with interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2af813fef2064ab42c80c4b651300e59
http://europepmc.org/abstract/med/2090435
http://europepmc.org/abstract/med/2090435
Publikováno v:
Europe PubMed Central
The insulin-like growth factor 2 (Igf-2) and H19 genes are physically linked on mouse distal chromosome 7 and are reciprocally imprinted. We investigated the molecular basis of the parental imprints in somatic cell cultures derived from normal embryo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5f4981f4df8fd57eda06d540fe6a378f
http://europepmc.org/abstract/med/7794801
http://europepmc.org/abstract/med/7794801
Publikováno v:
Europe PubMed Central
Hydroxymethyl glutaryl Co A reductase (HMG Co A reductase) is the key regulatory enzyme in the conversion of acetate to mevalonate. Mevalonate is the precursor for sterol and non-sterol isoprenes involved in membrane biogenesis, DNA replication and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0368c8d47cf990a85f56521eb972a27f
http://europepmc.org/abstract/med/6886611
http://europepmc.org/abstract/med/6886611
Publikováno v:
Europe PubMed Central
A stringent test for imprint control elements is to examine their function at ectopic loci in transgenic experiments. Igf2 and H19 are part of a larger imprinting region and as a first step, we examined these reciprocally imprinted genes in transgeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb70b1afb0afe17726eb4e59166d3e82
http://europepmc.org/abstract/med/9342054
http://europepmc.org/abstract/med/9342054
Publikováno v:
Europe PubMed Central
Imprinting is vital for normal development, and disruption of imprinting mechanisms on syntenic chromosomes gives very similar phenotypes in mouse and humans. In addition, disruption of normal imprinting provides a plausible explanation for preferent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a945f74042f3739306dd48249829be5d
http://europepmc.org/abstract/med/8718517
http://europepmc.org/abstract/med/8718517
Publikováno v:
Europe PubMed Central
Whole 8-cell morulae can be aggregated with isolated inner cell masses from blastocysts. On examining semithin light microscope sections of such aggregates we found that cells of the morula changed shape and spread over the surface of the ICM, thus t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::339798f4b7064a5050fec6c5676a2ef9
http://europepmc.org/abstract/med/7142894
http://europepmc.org/abstract/med/7142894