Staggered starts in the race to T cell activation

Autor: Richard, Arianne C., Frazer, Gordon L., Ma, Claire Y., Griffiths, Gillian M.

Publikováno v: In Trends in Immunology November 2021 42(11):994-1008

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PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes

Autor: Gawden-Bone, Christian M., Frazer, Gordon L., Richard, Arianne C., Ma, Claire Y., Strege, Katharina, Griffiths, Gillian M.

Publikováno v: Immunity

Summary How cytotoxic T lymphocytes (CTLs) sense T cell receptor (TCR) signaling in order to specialize an area of plasma membrane for granule secretion is not understood. Here, we demonstrate that immune synapse formation led to rapid localized chan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f97e9007867ada3d0c7a982fd7d4df01
https://www.repository.cam.ac.uk/handle/1810/283104

Mitochondrial translation is required for sustained killing by cytotoxic T cells

Autor: Miriam Lisci, Doreen A. Cantrell, Lyra O. Randzavola, Julien Prudent, Philippa R. Barton, Julia M. Marchingo, Claire Y. Ma, Vincent Paupe, Jane C. Stinchcombe, Gillian M. Griffiths

Publikováno v: Signal Transduction and Targeted Therapy

T cell receptor activation of naïve CD8+ T lymphocytes initiates their maturation into effector cytotoxic T lymphocytes (CTLs), which can kill cancer and virally infected cells. Although CTLs show an increased reliance on glycolysis upon acquisition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c406421e3035a3482a2c2c127216a169

PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes.

Autor: Gawden-Bone CM; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK., Frazer GL; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK., Richard AC; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK; Cancer Research UK Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0RE, UK., Ma CY; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK., Strege K; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK., Griffiths GM; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK. Electronic address: gg305@cam.ac.uk.

Publikováno v: Immunity [Immunity] 2018 Sep 18; Vol. 49 (3), pp. 427-437.e4. Date of Electronic Publication: 2018 Sep 11.