Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Ma, Cheng J."'
Autor:
Ma, Cheng J., Ren, Jun P., Li, Guang Y., Wu, Xiao Y., Brockstedt, Dirk G., Lauer, Peter, Moorman, Jonathan P., Yao, Zhi Q.
Publikováno v:
ETSU Faculty Works.
In this study, we engineered Listeria monocytogens (Lm) by deleting the LmΔactA/ΔinlB virulence determinants and inserting HCV-NS5B consensus antigens to develop a therapeutic vaccine against hepatitis C virus (HCV) infection. We tested this recomb
Externí odkaz:
https://dc.etsu.edu/etsu-works/15731
https://dc.etsu.edu/cgi/viewcontent.cgi?article=16997&context=etsu-works
https://dc.etsu.edu/cgi/viewcontent.cgi?article=16997&context=etsu-works
Autor:
Zhang, Ying, Ma, Cheng J., Wang, Jia M., Ji, Xiao J., Wu, Xiao Y., Jia, Zhan S., Moorman, Jonathan P., Yao, Zhi Q.
Publikováno v:
ETSU Faculty Works.
T cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) is a newly identified negative immunomodulator that is up-regulated on dysfunctional T cells during viral infections. The expression and function of Tim-3 on human innate immune resp
Externí odkaz:
https://dc.etsu.edu/etsu-works/16311
https://dc.etsu.edu/cgi/viewcontent.cgi?article=17577&context=etsu-works
https://dc.etsu.edu/cgi/viewcontent.cgi?article=17577&context=etsu-works
Autor:
Frazier, Ashley D., Zhang, Chun L., Ni, Lei, Ma, Cheng J., Zhang, Ying, Wu, Xiao Y., Atia, Antwan N., Yao, Zhi Q., Moorman, Jonathan P.
Publikováno v:
ETSU Faculty Works.
Chronic hepatitis C virus (HCV) infection is associated with T-cell exhaustion that is mediated through upregulation of the PD-1 negative regulatory pathway. PD-1 expression is induced by HCV core protein, which also induces upregulation of SOCS-1, a
Externí odkaz:
https://dc.etsu.edu/etsu-works/16832
Autor:
Yao, Zhi Q., Ni, Lei, Zhang, Ying, Ma, Cheng J., Zhang, Chun L., Dong, Zhi P., Frazier, Ashley D., Wu, Xiao Y., Thayer, Penny, Borthwick, Thomas, Chen, Xin Y., Moorman, Jonathan P.
Publikováno v:
ETSU Faculty Works.
HCV infection is associated with immune dysregulation and B cell Non-Hodgkins lymphoma (HCV-NHL). We have previously shown in vitro that HCV core protein differentially regulates T and B cell functions through two negative signaling pathways, program
Externí odkaz:
https://dc.etsu.edu/etsu-works/16457
Autor:
Ni, Lei, Ma, Cheng J., Zhang, Ying, Nandakumar, Subhadra, Zhang, Chun L., Wu, Xiao Y., Borthwick, Thomas, Hamati, Agnes, Chen, Xin Y., Kumaraguru, Uday, Moorman, Jonathan P., Yao, Zhi Q.
Publikováno v:
ETSU Faculty Works.
T regulatory (TR) cells suppress T-cell responses that are critical in the development of chronic viral infection and associated malignancies. Programmed death-1 (PD-1) also has a pivotal role in regulation of T-cell functions during chronic viral in
Externí odkaz:
https://dc.etsu.edu/etsu-works/16456
Autor:
Moorman, Jonathan P., Zhang, Chun L., Ni, Lei, Ma, Cheng J., Zhang, Ying, Wu, Xiao Y., Thayer, Penny, Islam, Tareq M., Borthwick, Thomas, Yao, Zhi Q.
Publikováno v:
ETSU Faculty Works.
Vaccination for hepatitis B virus (HBV) in the setting of hepatitis C virus (HCV) infection is recommended, but responses to vaccination are blunted when compared to uninfected populations. The mechanism for this failure of immune response in HCV-inf
Externí odkaz:
https://dc.etsu.edu/etsu-works/16417
Autor:
Ji, Xiao J., Ma, Cheng J., Wang, Jia M., Wu, Xiao Y., Niki, Toshiro, Hirashima, Mitsumi, Moorman, Jonathan P., Yao, Zhi Q.
Publikováno v:
ETSU Faculty Works.
HCV is remarkable at disrupting human immunity to establish chronic infection. The accumulation of Treg cells at the site of infection and upregulation of inhibitory signaling pathways (such as T-cell Ig and mucin domain protein-3 (Tim-3) and galecti
Externí odkaz:
https://dc.etsu.edu/etsu-works/14327
Autor:
Wang, Jia M., Shi, Lei, Ma, Cheng J., Ji, Xiao J., Ying, Ruo S., Wu, Xiao Y., Wang, Ke S., Li, Guangyu, Moorman, Jonathan P., Yao, Zhi Q.
Publikováno v:
ETSU Faculty Works.
Cytokine production by innate immunity is critical for shaping the adaptive immunity through regulation of T cell differentiation. In this report, we studied T cell immunoglobulin mucin domain protein 3 (Tim-3) expression on monocytes and its regulat
Externí odkaz:
https://dc.etsu.edu/etsu-works/14303
Autor:
Wang, Jia M., Ma, Cheng J., Li, Guang Y., Wu, Xiao Y., Thayer, Penny, Greer, Pamela, Smith, Ashley M., High, Kevin P., Moorman, Jonathan P., Yao, Zhi Q.
Publikováno v:
ETSU Faculty Works.
Hepatitis B virus (HBV) vaccination is recommended for individuals with hepatitis C virus (HCV) infection given their shared risk factors and increased liver-related morbidity and mortality upon super-infection. Vaccine responses in this setting are
Externí odkaz:
https://dc.etsu.edu/etsu-works/14288
Autor:
Ma, Cheng J., Li, Guang Y., Cheng, Yong Q., Wang, Jia M., Ying, Ruo S., Shi, Lei, Wu, Xiao Y., Niki, Toshiro, Hirashima, Mitsumi, Li, Chuan F., Moorman, Jonathan P., Yao, Zhi Q.
Publikováno v:
ETSU Faculty Works.
Human monocytes/macrophages (M/MΦ) of the innate immunity sense and respond to microbial products via specific receptor coupling with stimulatory (such as TLR) and inhibitory (such as Tim-3) receptors. Current models imply that Tim-3 expression on M
Externí odkaz:
https://dc.etsu.edu/etsu-works/14215