Zobrazeno 1 - 10
of 725
pro vyhledávání: '"MYCOLACTONE"'
Publikováno v:
BMC Infectious Diseases, Vol 23, Iss 1, Pp 1-13 (2023)
Abstract Background Mycobacterium ulcerans is the causative agent of Buruli ulcer. The pathology of M. ulcerans disease has been attributed to the secretion of a potent macrolide cytotoxin known as mycolactone which plays an important role in the vir
Externí odkaz:
https://doaj.org/article/a6de7d1473ad497ea1fc8987a6c4b384
Akademický článek
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Publikováno v:
Toxins, Vol 15, Iss 8, p 486 (2023)
Mycolactone is an exotoxin produced by Mycobacterium ulcerans that causes the neglected tropical skin disease Buruli ulcer. This toxin inhibits the Sec61 translocon in the endoplasmic reticulum (ER), preventing the host cell from producing several se
Externí odkaz:
https://doaj.org/article/10d4da25abf74954a193e0545b81f5eb
Autor:
Marie Robbe-Saule, Mélanie Foulon, Isabelle Poncin, Lucille Esnault, Hugo Varet, Rachel Legendre, Alban Besnard, Anna E. Grzegorzewicz, Mary Jackson, Stéphane Canaan, Laurent Marsollier, Estelle Marion
Publikováno v:
Virulence, Vol 12, Iss 1, Pp 1438-1451 (2021)
Mycobacterium ulcerans is the causal agent of Buruli ulcer, a chronic infectious disease and the third most common mycobacterial disease worldwide. Without early treatment, M. ulcerans provokes massive skin ulcers, caused by the mycolactone toxin, it
Externí odkaz:
https://doaj.org/article/1cb69814d64d40b389c32a0800f06a86
Autor:
Daniela Ricci, Caroline Demangel
Publikováno v:
Toxins, Vol 15, Iss 6, p 369 (2023)
“Recognizing a surprising fact is the first step towards discovery.” This famous quote from Louis Pasteur is particularly appropriate to describe what led us to study mycolactone, a lipid toxin produced by the human pathogen Mycobacterium ulceran
Externí odkaz:
https://doaj.org/article/3f37f5cab0ac40d4a84774e432a298ec
Autor:
Elizabeth Gyamfi, Magdalene Amerl Dogbe, Charles Quaye, Abel Adjet Affouda, Edwin Kyei-Baffour, Daisy Awuku-Asante, Mabel Sarpong-Duah, Lydia Mosi
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Buruli ulcer (BU), a necrotic skin disease caused by Mycobacterium ulcerans, is mainly prevalent in West Africa, but cases have also been reported in other tropical parts of the world. It is the second most common mycobacterial disease after tubercul
Externí odkaz:
https://doaj.org/article/4406e42a2e834b188c3a475428caff2b
Autor:
Yaw Ampem Amoako, Aloysius Dzigbordi Loglo, Michael Frimpong, Bernadette Agbavor, Mohammed Kabiru Abass, George Amofa, Elizabeth Ofori, Edwin Ampadu, Kingsley Asiedu, Ymkje Stienstra, Mark Wansbrough-Jones, Tjip van der Werf, Richard Odame Phillips
Publikováno v:
BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-11 (2021)
Abstract Background Previous studies have reported that presence and severity of Buruli ulcer (BU) may reflect the underlying immunosuppression in HIV infected individuals by causing increased incidence of multiple, larger and ulcerated lesions. We r
Externí odkaz:
https://doaj.org/article/7a0a04bd987c49e592e4bcf93f1929b2
Autor:
Seth Osei Asiedu, Yash Gupta, Vlad Nicolaescu, Haley Gula, Thomas R. Caulfield, Ravi Durvasula, Prakasha Kempaiah, Samuel K. Kwofie, Michael D. Wilson
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7151 (2023)
We have previously shown computationally that Mycolactone (MLN), a toxin produced by Mycobacterium ulcerans, strongly binds to Munc18b and other proteins, presumably blocking degranulation and exocytosis of blood platelets and mast cells. We investig
Externí odkaz:
https://doaj.org/article/9072fccb32d7427ea6459101183283f0
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Mycobacterium ulcerans is the causative agent of Buruli ulcer (BU), the third most common mycobacterial infection. Virulent M. ulcerans secretes mycolactone, a polyketide toxin. Most observations of M. ulcerans infection are described as an extracell
Externí odkaz:
https://doaj.org/article/20e82cec8ded49c8a7a047ec8ae4de7d
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Buruli ulcer (BU), caused by Mycobacterium ulcerans, is a devastating necrotizing skin disease. Key to its pathogenesis is mycolactone, the exotoxin virulence factor that is both immunosuppressive and cytotoxic. The discovery that the essential Sec61
Externí odkaz:
https://doaj.org/article/8fd9db267fa0486eb617a7bc1a5eee1e