MAGI2‐AS3 suppresses MYC signaling to inhibit cell proliferation and migration in ovarian cancer through targeting miR‐525‐5p/MXD1 axis

Autor: Hua Chang, Xue Zhang, Baixue Li, Xiangkai Meng

Publikováno v: Cancer Medicine, Vol 9, Iss 17, Pp 6377-6386 (2020)

Abstract Ovarian cancer (OV) is one of the most lethal gynecological malignance in females, and usually diagnosed at advanced stages. Long noncoding RNAs (lncRNAs) exhibit their crucial functions in modulatory mechanisms of cancers. Substantive studi

Externí odkaz: https://doaj.org/article/bdf5586e3c9c4d1abd7904fec0d61efa

Targeting miR-21 with NL101 blocks c-Myc/Mxd1 loop and inhibits the growth of B cell lymphoma

Autor: Wenbin Qian, Xi Qiu, Panpan Chen, Teng Yu, Yang Xu, Limin Lin, Shu Li, Xuzhao Zhang, Jiefeng Tong, Jiawei Zhang, Yichao Gan, Feiqiong Gao, Xin He

Publikováno v: Theranostics

Background: NL101 has shown activities against multiple myeloma and acute myeloid leukemia, but its anti-lymphoma activity remains unknown. The transcription factor c-Myc is frequently dysregulated in aggressive B cell lymphomas such as double-hit ly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f183d1a2ba63489b1abd9f136a4a3ea2
http://europepmc.org/articles/PMC7847677

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MXD1 is a Potential Prognostic Biomarker and Correlated With Specific Molecular Change and Tumor Microenvironment Feature in Esophageal Squamous Cell Carcinoma

Autor: Feng Du, Xiaodong Zhang, Dezuo Dong, Jun Jia

Publikováno v: Technology in Cancer Research & Treatment, Vol 20 (2021)
Technology in Cancer Research & Treatment

Background: Identification of novel biomarkers is crucial for the diagnosis and treatment of esophageal squamous cell carcinoma (ESCC). This study aimed to reveal the clinical significance and molecular characteristics of MYC-associated factor X dime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7325b418140316898284b5de090966ec
https://doaj.org/article/541aab1bd2344a2e82429e889b1ff862

MXD1 localizes in the nucleolus, binds UBF and impairs rRNA synthesis

Autor: Maria del Carmen Lafita-Navarro, Javier León, Miguel Lafarga, Olga Tapia, Eva Garcia-Alegria, Judit Liaño-Pons, Maria T. Berciano, Rosa M. Blanco, Lucía García-Gutiérrez, Jorge Mata-Garrido

Publikováno v: Oncotarget
Oncotarget. 2016 Aug 31
Lafita-Navarro, M D C, Blanco, R, Mata-Garrido, J, Liaño-Pons, J, Tapia, O, García-Gutiérrez, L, García-Alegría, E, Berciano, M T, Lafarga, M & León, J 2016, ' MXD1 localizes in the nucleolus, binds UBF and impairs rRNA synthesis ', Oncotarget, vol. 7, no. 43, pp. 69536-69548 . https://doi.org/10.18632/oncotarget.11766
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Digital.CSIC. Repositorio Institucional del CSIC
instname

MXD1 is a protein that interacts with MAX, to form a repressive transcription factor. MXD1-MAX binds E-boxes. MXD1-MAX antagonizes the transcriptional activity of the MYC oncoprotein in most models. It has been reported that MYC overexpression leads

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e12896454ac5545fac978ba8c41e44
https://doi.org/10.18632/oncotarget.11766