Zobrazeno 1 - 10
of 93
pro vyhledávání: '"MVB enlargement"'
Autor:
Willén, Katarina1, Edgar, James R.2,3, Takafumi Hasegawa4, Nobuyuki Tanaka5, Futter, Clare E.3, Gouras, Gunnar K.1 gunnar.gouras@med.lu.se
Publikováno v:
Molecular Neurodegeneration. 8/23/2017, Vol. 12, p1-18. 18p. 1 Diagram, 6 Graphs.
Autor:
Nobuyuki Tanaka, Takafumi Hasegawa, Clare E. Futter, James R. Edgar, Gunnar K. Gouras, Katarina Willén
Publikováno v:
Molecular Neurodegeneration
Background Alzheimer’s disease (AD)-linked β-amyloid (Aβ) accumulates in multivesicular bodies (MVBs) with the onset of AD pathogenesis. Alterations in endosomes are among the earliest changes associated with AD but the mechanism(s) that cause en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da0dc55891e99a0806813dfe0d8470e
https://doi.org/10.1186/s13024-017-0203-y
https://doi.org/10.1186/s13024-017-0203-y
Autor:
Willén, Katarina, Edgar, James, Hasegawa, Takafumi, Tanaka, Nobuyuki, Futter, Clare, Gouras, Gunnar
Aβ1-42 increases the diameter of LAMP-1 positive vesicles in N2a cells. Confocal images of exogenously added monomeric Aβ1-42 incubated for different time points, ranging from 15 min to 48 h, in N2a cells. 3D-rendering with Imaris from confocal z-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57fc8efc3767925ea3ed0ab0801b8445
Autor:
Willén, Katarina, Edgar, James, Hasegawa, Takafumi, Tanaka, Nobuyuki, Futter, Clare, Gouras, Gunnar
DnVPS4A increases secretion but does not change levels of intracellular α-syn. (A) Western blot analysis of α-syn N2a cells transfected with dnVPS4A shows increased levels of extracellular α-synuclein without altering the total pool of intracellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b3548ae91a93ae8d987eec4fb011d80
Autor:
Willén, Katarina, Edgar, James, Hasegawa, Takafumi, Tanaka, Nobuyuki, Futter, Clare, Gouras, Gunnar
(A) Western blot analysis of APP and Aβ in Swe N2a cells treated with 40 μg/ml cycloheximide (CHX) at different times in hours (h) before harvest. Cell culture media was replaced with fresh media 24 h before harvest. For quantification, values are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6710fe37358b74d997447f1f013085b5
Autor:
Willén, Katarina, Edgar, James, Hasegawa, Takafumi, Tanaka, Nobuyuki, Futter, Clare, Gouras, Gunnar
(A) Western blot analysis of APP and Aβ in Swe N2a cells treated with 5 nM bafilomycin A1 (BafA1) at different time points (h) before harvest. Cell culture media was replaced with fresh media 24 h before harvest. (B) Quantification of A. Values are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::341a5ef5a8332de14d86a0bcd25cdbe1
Autor:
Willén, Katarina, Edgar, James, Hasegawa, Takafumi, Tanaka, Nobuyuki, Futter, Clare, Gouras, Gunnar
(A) EM image of an enlarged MVB in wt neurons treated with Aβ1-42. This image shows an example of an enlarged MVB with very few ILVs. (B) Confocal analysis of changes in size of LAMP1-positive structures in Aβ1-42 treated wt primary neurons with ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6278c8ed62025f1a3a8c9ea7bf15c8f8
Autor:
Willén, Katarina, Edgar, James, Hasegawa, Takafumi, Tanaka, Nobuyuki, Futter, Clare, Gouras, Gunnar
ESCRT proteins in primary neurons and plaques. (A-B) In young 3-month-old Tg19959 mice, CHMP2B immunolabelling is increased in areas of hippocampus (a) and entorhinal cortex (b) that also have increased labelling of APP/Aβ (6E10). Scale bar 40 μm,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::064b1ce1001e538e6a23f68600d7a799
Autor:
Willén, Katarina, Edgar, James, Hasegawa, Takafumi, Tanaka, Nobuyuki, Futter, Clare, Gouras, Gunnar
(A) Confocal analysis of wt primary neurons show that untreated (DMSO) cells have no OC labelling, while cells incubated with Aβ1-40 for 48 h have low levels of OC labelling. However, cells incubated with Aβ1-42 display very strong OC labelling. (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fb656090700005315b3470f8472121b
Autor:
Willén, Katarina, Edgar, James, Hasegawa, Takafumi, Tanaka, Nobuyuki, Futter, Clare, Gouras, Gunnar
List of antibodies. (PDF 5545 kb)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0551fa1d5639ccbd472c0585b9fbaf93