Disc in flames: Roles of TNF-α and IL-1β in intervertebral disc degeneration

Autor: ZI Johnson, ZR Schoepflin, H Choi, IM Shapiro, MV Risbud

Publikováno v: European Cells & Materials, Vol 30, Pp 104-117 (2015)

The intervertebral disc is an important mechanical structure that allows range of motion of the spinal column. Degeneration of the intervertebral disc – incited by aging, traumatic insult, genetic predisposition, or other factors – is often defin

Externí odkaz: https://doaj.org/article/35a3ff0d41824b729ea8c7e570e41a4c

SIRT6 loss causes intervertebral disc degeneration in mice by promoting senescence and SASP status.

Autor: Ramteke P; Department of Orthopedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, 19107, USA., Watson B; Department of Orthopedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, 19107, USA., Toci M; Department of Orthopedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, 19107, USA., Tran VA; Department of Orthopedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, 19107, USA., Johnston S; Department of Orthopedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, 19107, USA., Tsingas M; Department of Orthopedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, 19107, USA., Barve RA; Department of Genetics, Genome Technology Access Centre at the McDonnell Genome Institute, Washington University, School of Medicine, St. Louis, MO, 63110, USA., Mitra R; Department of Pharmacology and Biostatistics, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Loeser RF; Thurston Arthritis Research Center and the Division of Rheumatology, Allergy, and Immunology, 3300 Thurston Building, Campus Box 7280, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599-7280, USA., Collins JA; Department of Orthopedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, 19107, USA., Risbud MV; Department of Orthopedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, 19107, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 09. Date of Electronic Publication: 2024 Sep 09.

Sdc4 deletion perturbs intervertebral disc matrix homeostasis and promotes early osteopenia in the aging mouse spine.

Autor: Sao K; Graduate Program in Cell Biology and Regenerative Medicine, Jefferson College of Life Sciences, Thomas Jefferson University, Philadelphia, United States; Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, 1025 Walnut Street, Suite 501 College Bldg., Philadelphia, PA 19107, United States., Risbud MV; Graduate Program in Cell Biology and Regenerative Medicine, Jefferson College of Life Sciences, Thomas Jefferson University, Philadelphia, United States; Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, 1025 Walnut Street, Suite 501 College Bldg., Philadelphia, PA 19107, United States. Electronic address: makarand.risbud@jefferson.edu.

Publikováno v: Matrix biology : journal of the International Society for Matrix Biology [Matrix Biol] 2024 Aug; Vol. 131, pp. 46-61. Date of Electronic Publication: 2024 May 26.

Increased HIF-2α activity in the nucleus pulposus causes intervertebral disc degeneration in the aging mouse spine.

Autor: Johnston SN; Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, United States.; Graduate Program in Cell Biology and Regenerative Medicine, Jefferson College of Life Sciences, Thomas Jefferson University, Philadelphia, PA, United States., Tsingas M; Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, United States.; Graduate Program in Cell Biology and Regenerative Medicine, Jefferson College of Life Sciences, Thomas Jefferson University, Philadelphia, PA, United States., Ain R; Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, United States.; Graduate Program in Pharmacology, Jefferson College of Life Sciences, Thomas Jefferson University, Philadelphia, PA, United States., Barve RA; Department of Genetics, Genome Technology Access Centre at the McDonnell Genome Institute, Washington University, School of Medicine, St. Louis, MO, United States., Risbud MV; Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, United States.; Graduate Program in Cell Biology and Regenerative Medicine, Jefferson College of Life Sciences, Thomas Jefferson University, Philadelphia, PA, United States.

Publikováno v: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2024 Mar 06; Vol. 12, pp. 1360376. Date of Electronic Publication: 2024 Mar 06 (Print Publication: 2024).

A new perspective on intervertebral disc calcification-from bench to bedside.

Autor: Novais EJ; Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.; Unidade Local de Saúde do Litoral Alentejano, Orthopedic Department, Santiago do Cacém, Portugal., Narayanan R; Rothman Orthopedic Institute at Thomas Jefferson University, Philadelphia, PA, USA., Canseco JA; Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.; Rothman Orthopedic Institute at Thomas Jefferson University, Philadelphia, PA, USA., van de Wetering K; Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA., Kepler CK; Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.; Rothman Orthopedic Institute at Thomas Jefferson University, Philadelphia, PA, USA., Hilibrand AS; Rothman Orthopedic Institute at Thomas Jefferson University, Philadelphia, PA, USA., Vaccaro AR; Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.; Rothman Orthopedic Institute at Thomas Jefferson University, Philadelphia, PA, USA., Risbud MV; Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA. Makarand.Risbud@jefferson.edu.

Publikováno v: Bone research [Bone Res] 2024 Jan 22; Vol. 12 (1), pp. 3. Date of Electronic Publication: 2024 Jan 22.