Repression of latent NF-κB enhancers by PDX1 regulates β cell functional heterogeneity.

Autor: Weidemann BJ; Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Marcheva B; Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Kobayashi M; Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Omura C; Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Newman MV; Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Kobayashi Y; Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Waldeck NJ; Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Perelis M; Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Ionis Pharmaceuticals, Carlsbad, CA 92010, USA., Lantier L; Vanderbilt-NIH Mouse Metabolic Phenotyping Center, Nashville, TN 37232, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., McGuinness OP; Vanderbilt-NIH Mouse Metabolic Phenotyping Center, Nashville, TN 37232, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Ramsey KM; Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Stein RW; Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Bass J; Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: j-bass@northwestern.edu.

Publikováno v: Cell metabolism [Cell Metab] 2024 Jan 02; Vol. 36 (1), pp. 90-102.e7.

P2Y1 purinergic receptor identified as a diabetes target in a small-molecule screen to reverse circadian β-cell failure.

Autor: Marcheva B; Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States., Weidemann BJ; Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States., Taguchi A; Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States.; Division of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio-Signal Analysis, Yamaguchi University, Graduate School of Medicine, 1-1-1, Yamaguchi, Japan., Perelis M; Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States.; Ionis Pharmaceuticals, Inc, Carlsbad, United States., Ramsey KM; Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States., Newman MV; Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States., Kobayashi Y; Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States., Omura C; Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States., Manning Fox JE; Department of Pharmacology, Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada., Lin H; Department of Pharmacology, Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada., Macdonald PE; Department of Pharmacology, Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada., Bass J; Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States.

Publikováno v: ELife [Elife] 2022 Feb 21; Vol. 11. Date of Electronic Publication: 2022 Feb 21.

A role for alternative splicing in circadian control of exocytosis and glucose homeostasis.

Autor: Marcheva B; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA., Perelis M; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA., Weidemann BJ; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA., Taguchi A; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA., Lin H; Department of Pharmacology, Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada., Omura C; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA., Kobayashi Y; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA., Newman MV; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA., Wyatt EJ; Center for Genetic Medicine, Northwestern University, Chicago, Illinois 60611, USA., McNally EM; Center for Genetic Medicine, Northwestern University, Chicago, Illinois 60611, USA., Fox JEM; Department of Pharmacology, Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada., Hong H; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA., Shankar A; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA., Wheeler EC; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA., Ramsey KM; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA., MacDonald PE; Department of Pharmacology, Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada., Yeo GW; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA., Bass J; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

Publikováno v: Genes & development [Genes Dev] 2020 Aug 01; Vol. 34 (15-16), pp. 1089-1105. Date of Electronic Publication: 2020 Jul 02.

Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic beta-cell function.

Autor: El Muayed M; Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Tarry 15-755, Chicago, Illinois 60611, USA. m-muayed@northwestern.edu, Billings LK, Raja MR, Zhang X, Park PJ, Newman MV, Kaufman DB, O'Halloran TV, Lowe WL Jr

Publikováno v: The Journal of endocrinology [J Endocrinol] 2010 Aug; Vol. 206 (2), pp. 159-69. Date of Electronic Publication: 2010 May 27.

Insulin-like growth factor I activates c-Jun N-terminal kinase in MCF-7 breast cancer cells.

Autor: Monno S; Center for Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Veterans Administration Chicago Healthcare System-Lakeside Division and Northwestern University Medical School, Illinois 60611, USA., Newman MV, Cook M, Lowe WL Jr

Publikováno v: Endocrinology [Endocrinology] 2000 Feb; Vol. 141 (2), pp. 544-50.