Výsledky vyhledávání - "MV, missense variant"

Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling

Autor: Jordan M. Mattheisen, Amanda R. Moore, Yu Chen, Ping Chi, Manija A. Kazmi, Tyler D. Hitchman, Mizuho Horioka, Thomas P. Sakmar, Emilie Ceraudo, Thomas Huber

Publikováno v: The Journal of Biological Chemistry

Uveal melanoma is the most common eye cancer in adults and is clinically and genetically distinct from skin cutaneous melanoma. In a subset of cases, the oncogenic driver is an activating mutation in CYSLTR2, the gene encoding the G protein–coupled

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5ec74a731e85fd58a86e6fd59224fd
https://doi.org/10.1074/jbc.ra120.015352

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