Zobrazeno 1 - 10
of 2 477
pro vyhledávání: '"MULTIDRUG-RESISTANCE PROTEIN"'
Autor:
Tomohisa Iinuma, Syuji Yonekura, Kiyoshi Hirahara, Junya Kurita, Riyo Yoneda, Tomoyuki Arai, Yuri Sonobe, Rie Shinmi, Yoshitaka Okamoto, Toyoyuki Hanazawa
Publikováno v:
Allergology International, Vol 72, Iss 4, Pp 564-572 (2023)
Background: Chronic rhinosinusitis is a common disease of the nasal cavity and is classified into two major endotypes, which are neutrophilic and eosinophilic. Some patients with neutrophilic and eosinophilic chronic rhinosinusitis are refractory to
Externí odkaz:
https://doaj.org/article/fbf0431244244690b539881fd61e468c
Autor:
Christopher K. Murphy, Bharat Dixit, Frederick B. Oleson, Roland E. Dolle, Ronald Farquhar, Beth A. McCormick
Publikováno v:
FEBS Open Bio, Vol 13, Iss 8, Pp 1434-1446 (2023)
Neutrophils are an essential component of the innate immune system; however, uncontrolled neutrophil activity can lead to inflammation and tissue damage in acute and chronic diseases. Despite inclusion of neutrophil presence and activity in clinical
Externí odkaz:
https://doaj.org/article/2f385952491244dc92805ee02671f920
Publikováno v:
Exploration of Digestive Diseases, Vol 2, Iss 2, Pp 34-43 (2023)
Hereditary cholestasis comprises a broad spectrum of clinical phenotypes of varying severity. Severe forms such as progressive familial intrahepatic cholestasis (PFIC) mostly affect children with disease onset within their first years. Nevertheless,
Externí odkaz:
https://doaj.org/article/efb2b2f47c55463c8153afc6c666d7d9
Akademický článek
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Autor:
Jiahong Wang
Publikováno v:
Brazilian Journal of Pharmaceutical Sciences, Vol 59 (2023)
Abstract The aim of the present study was to investigate the usefulness of multidrug resistance protein 1 (MDR1) and neuropeptide Y (NPY) levels in predicting the efficacy of levetiracetam (LEV) plus oxcarbazepine (OXC) treatment administered to chil
Externí odkaz:
https://doaj.org/article/f52f1353e3a64c2283178ff2b834e7ee
The Function and Expression of ATP-Binding Cassette Transporters Proteins in the Alzheimer's Disease
Autor:
Asli Aykac, Ahmet Özer Sehirli
Publikováno v:
Global Medical Genetics, Vol 08, Iss 04, Pp 149-155 (2021)
Despite many years of research, radical treatment of Alzheimer's disease (AD) has still not been found. Amyloid-β (Aβ) peptide is known to play an important role in the pathogenesis of this disease. AD is characterized by three main changes occurri
Externí odkaz:
https://doaj.org/article/7c3a21cc02674b059b83186f8ced0d41
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Lenvatinib is the first-line treatment for hepatocellular carcinoma (HCC), the most common type of primary liver cancer; however, some patients become refractory to lenvatinib. The underlying mechanism of lenvatinib resistance (LR) in patients with a
Externí odkaz:
https://doaj.org/article/897a9fd5e2a249808da3beaff7cf288c
Autor:
Negin Namazian Jam, Felix Gottlöber, Melanie Hempel, Yuliya Dzekhtsiarova, Stephan Behrens, Frank Sonntag, Jan Sradnick, Christian Hugo, Florian Schmieder
Publikováno v:
Biomedicines, Vol 11, Iss 7, p 2045 (2023)
Despite disadvantages, such as high cost and their poor predictive value, animal experiments are still the state of the art for pharmaceutical substance testing. One reason for this problem is the inability of standard cell culture methods to emulate
Externí odkaz:
https://doaj.org/article/e33315a6a2b049b29e042def37535939
Publikováno v:
Microorganisms, Vol 11, Iss 6, p 1612 (2023)
Multidrug resistance (Mdr) proteins are critical proteins for maintenance of drug resistance in fungi. Mdr1 has been extensively studied in Candida albicans; its role in other fungi is largely unknown. In this study, we identified a homologous protei
Externí odkaz:
https://doaj.org/article/5c51eada6aef49178efdd9e3beddf810
Publikováno v:
Veterinary World, Vol 14, Iss 1, Pp 33-39 (2021)
Background and Aim: Trypanosomiasis, also known as surra, is an infectious disease with a wide host spectrum. In Indonesia, this disease is caused by Trypanosoma evansi. Various trypanocidal drugs have been used to treat this pathogen and subsequent
Externí odkaz:
https://doaj.org/article/e2610f8765eb4843bc739ae8157480d7