The past, present, and future of breast cancer models for nanomedicine development

Autor: Paz Boix-Montesinos, Mar Orzáez, Ana Armiñán, Paula M. Soriano-Teruel, María J. Vicent

Publikováno v: Advanced Drug Delivery Reviews

Graphical abstract
Even given recent advances in nanomedicine development of breast cancer treatment in recent years and promising results in pre-clinical models, cancer nanomedicines often fail at the clinical trial stage. Limitations of conven

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76811ce2af0ea0f7b3342230007c3c01
https://doi.org/10.1016/j.addr.2021.03.018

The sialidase NEU1 directly interacts with the juxtamembranous segment of the cytoplasmic domain of mucin-1 to inhibit downstream PI3K-Akt signaling

Autor: Sang W. Hyun, Hideharu Ishida, Akihiro Imamura, Simeon E. Goldblum, Erik P. Lillehoj, Kurt H. Piepenbrink

Publikováno v: The Journal of Biological Chemistry

The extracellular domain (ED) of the membrane-spanning sialoglycoprotein, mucin-1 (MUC1), is an in vivo substrate for the lysosomal sialidase, neuraminidase-1 (NEU1). Engagement of the MUC1-ED by its cognate ligand, Pseudomonas aeruginosa-expressed f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc5cb166a1864c8274f33d17bbe381c
https://doi.org/10.1016/j.jbc.2021.101337

Trial Watch: Peptide-based anticancer vaccines

Autor: Jonathan Pol, Norma Bloy, Aitziber Buqué, Alexander Eggermont, Isabelle Cremer, Catherine Sautès-Fridman, Jérôme Galon, Eric Tartour, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi

Publikováno v: Oncoimmunology
ResearcherID

Malignant cells express antigens that can be harnessed to elicit anticancer immune responses. One approach to achieve such goal consists in the administration of tumor-associated antigens (TAAs) or peptides thereof as recombinant proteins in the pres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d4e7cf8a662b12610765a546fe03ad1
http://europepmc.org/articles/PMC4485775

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Trial watch: Dendritic cell-based anticancer therapy.

Autor: Bloy N; Gustave Roussy Cancer Campus ; Villejuif, France ; INSERM , U1138; Paris France ; Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Centre de Recherche des Cordeliers ; Paris France ; Université Paris-Sud/Paris XI ; Orsay, France., Pol J; Gustave Roussy Cancer Campus ; Villejuif, France ; INSERM , U1138; Paris France ; Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Centre de Recherche des Cordeliers ; Paris France., Aranda F; Gustave Roussy Cancer Campus ; Villejuif, France ; INSERM , U1138; Paris France ; Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Centre de Recherche des Cordeliers ; Paris France., Eggermont A; Gustave Roussy Cancer Campus ; Villejuif, France., Cremer I; INSERM , U1138; Paris France ; Equipe 13; Centre de Recherche des Cordeliers ; Paris France ; Université Pierre et Marie Curie/Paris VI ; Paris France., Fridman WH; INSERM , U1138; Paris France ; Equipe 13; Centre de Recherche des Cordeliers ; Paris France ; Université Pierre et Marie Curie/Paris VI ; Paris France., Fučíková J; Department of Immunology; 2nd Medical School Charles University and University Hospital Motol ; Prague, Czech Republic ; Sotio a.s. ; Prague, Czech Republic., Galon J; INSERM , U1138; Paris France ; Université Pierre et Marie Curie/Paris VI ; Paris France ; Laboratory of Integrative Cancer Immunology; Centre de Recherche des Cordeliers ; Paris France ; Université Paris Descartes/Paris V; Sorbonne Paris Cité ; Paris France., Tartour E; Université Paris Descartes/Paris V; Sorbonne Paris Cité ; Paris France ; INSERM , U970; Paris France ; Pôle de Biologie; Hôpital Européen Georges Pompidou, AP-HP ; Paris France., Spisek R; Department of Immunology; 2nd Medical School Charles University and University Hospital Motol ; Prague, Czech Republic ; Sotio a.s. ; Prague, Czech Republic., Dhodapkar MV; Department of Medicine; Immunobiology and Yale Cancer Center; Yale University ; New Haven, CT USA., Zitvogel L; Gustave Roussy Cancer Campus ; Villejuif, France ; INSERM, U1015, CICBT507 ; Villejuif, France., Kroemer G; INSERM , U1138; Paris France ; Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Centre de Recherche des Cordeliers ; Paris France ; Université Paris Descartes/Paris V; Sorbonne Paris Cité ; Paris France ; Pôle de Biologie; Hôpital Européen Georges Pompidou, AP-HP ; Paris France ; Metabolomics and Cell Biology Platforms; Gustave Roussy Cancer Campus ; Villejuif, France., Galluzzi L; Gustave Roussy Cancer Campus ; Villejuif, France ; INSERM , U1138; Paris France ; Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Centre de Recherche des Cordeliers ; Paris France ; Université Paris Descartes/Paris V; Sorbonne Paris Cité ; Paris France.

Publikováno v: Oncoimmunology [Oncoimmunology] 2014 Dec 21; Vol. 3 (11), pp. e963424. Date of Electronic Publication: 2014 Dec 21 (Print Publication: 2014).