Zobrazeno 1 - 10
of 15
pro vyhledávání: '"MTase, methyltransferase"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 4684-4701 (2021)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
Safer and more-effective drugs are urgently needed to counter infections with the highly pathogenic SARS-CoV-2, cause of the COVID-19 pandemic. Identification of efficient inhibitors to treat and prevent SARS-CoV-2 infection i
Safer and more-effective drugs are urgently needed to counter infections with the highly pathogenic SARS-CoV-2, cause of the COVID-19 pandemic. Identification of efficient inhibitors to treat and prevent SARS-CoV-2 infection i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9bba885f52a030829148a7dd4dbf93
http://www.sciencedirect.com/science/article/pii/S2001037021003603
http://www.sciencedirect.com/science/article/pii/S2001037021003603
Autor:
Bruno Canard, Etienne Decroly, Mathis Guiraud, Priscila Sutto-Ortiz, Françoise Debart, Rostom Ahmed-Belkacem, Jean-Jacques Vasseur
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2020, 201, pp.112557. ⟨10.1016/j.ejmech.2020.112557⟩
European Journal of Medicinal Chemistry, Elsevier, 2020, 201, pp.112557. ⟨10.1016/j.ejmech.2020.112557⟩
European Journal of Medicinal Chemistry, 2020, 201, pp.112557. ⟨10.1016/j.ejmech.2020.112557⟩
European Journal of Medicinal Chemistry, Elsevier, 2020, 201, pp.112557. ⟨10.1016/j.ejmech.2020.112557⟩
The spreading of new viruses is known to provoke global human health threat. The current COVID-19 pandemic caused by the recently emerged coronavirus SARS-CoV-2 is one significant and unfortunate example of what the world will have to face in the fut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe31e202437a14c3c7697f57a625709
Autor:
Elizabeth A. Campbell, Uli Schmitz, John P. Bilello, Joy Y. Feng, Jason K. Perry, Todd C. Appleby
Publikováno v:
The Journal of Biological Chemistry
Using available cryo-EM and x-ray crystal structures of the nonstructural proteins that are responsible for SARS-CoV-2 viral RNA replication and transcription, we have constructed an atomistic model of how the proteins assemble into a functioning sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::777a54a79a0edaa70eacb7b025c6ab0e
https://doi.org/10.1016/j.jbc.2021.101218
https://doi.org/10.1016/j.jbc.2021.101218
Autor:
Joshua J. Hamey, Ryan J. Separovich, Marc R. Wilkins, Tyler R. Chapman, Mandy W.M. Wong, Eve Slavich
Publikováno v:
The Journal of Biological Chemistry
Histone methylation is central to the regulation of eukaryotic transcription. In Saccharomyces cerevisiae, it is controlled by a system of four methyltransferases (Set1p, Set2p, Set5p, and Dot1p) and four demethylases (Jhd1p, Jhd2p, Rph1p, and Gis1p)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::091eea8b073f99c0bc4246be28d7b415
https://doi.org/10.1074/jbc.ra120.015995
https://doi.org/10.1074/jbc.ra120.015995
Publikováno v:
The Journal of Biological Chemistry
RNA methylations of varied RNA species (mRNA, tRNA, rRNA, non-coding RNA) generate a range of modified nucleotides, including N6-methyladenosine. Here we study the enzymology of three human RNA methyltransferases that methylate the adenosine amino gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a4ab248616402e3589eb2e40366295
https://doi.org/10.1016/j.jbc.2021.100270
https://doi.org/10.1016/j.jbc.2021.100270
Autor:
Lingpeng Cheng, Feng Song, Chongwen Yang, Xiaojun Huang, Bin Zhu, Ping Zhu, Songjun Zeng, Hongrong Liu, Gang Ji
Publikováno v:
Journal of Molecular Biology
Many double-stranded RNA (dsRNA) viruses are capable of transcribing and capping RNA within a stable icosahedral viral capsid. The turret of turreted dsRNA viruses belonging to the family Reoviridae is formed by five copies of the turret protein, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a58dafae207773dcb67910a596197a
https://doi.org/10.1016/j.jmb.2014.03.013
https://doi.org/10.1016/j.jmb.2014.03.013
Characterization of the guanine-N7 methyltransferase activity of coronavirus nsp14 on nucleotide GTP
Autor:
Jiali Tao, Xu Jin, Zhou Zhang, Yi Wang, Deyin Guo, Yu Chen, Cong Zeng, Ying Sun, Andong Wu, Jie Tian, Xiao Yu
Publikováno v:
Virus Research
Highlights • We found SARS-CoV nsp14 could methylate GTP and dGTP. • Critical residues of nsp14 essential for the activity on GTP were identified. • m7GTP or nsp14 could interfere with protein translation.
Most eukaryotic viruses that repl
Most eukaryotic viruses that repl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351364541ce44ca92380d80632ca95ac
https://doi.org/10.1016/j.virusres.2013.05.001
https://doi.org/10.1016/j.virusres.2013.05.001
Publikováno v:
Journal of Molecular Biology
The Type I R-M system EcoR124I is encoded by three genes. HsdM is responsible for modification (DNA methylation), HsdS for DNA sequence specificity and HsdR for restriction endonuclease activity. The trimeric methyltransferase (M(2)S) recognises the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a9184b2242c1d5a6ad2311e3f83ac0f
https://doi.org/10.1016/j.jmb.2010.03.008
https://doi.org/10.1016/j.jmb.2010.03.008
Shape and Subunit Organisation of the DNA Methyltransferase M.AhdI by Small-angle Neutron Scattering
Publikováno v:
Journal of Molecular Biology
Type I restriction-modification (R-M) systems encode multisubunit/multidomain enzymes. Two genes (M and S) are required to form the methyltransferase (MTase) that methylates a specific base within the recognition sequence and protects DNA from cleava
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce3d180fdaad871427f28f288e48d7d
Autor:
Carlos Santos-Ocaña, Mara Doimo, Leonardo Salviati, Alberto Casarin, Eva Trevisson, Plácido Navas, Theresa Nguyen, Maria Andrea Desbats, Catherine F. Clarke
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biochimica et Biophysica Acta
instname
Biochimica et Biophysica Acta
Under a Creative Commons license.
Coq5 catalyzes the only C-methylation involved in the biosynthesis of coenzyme Q (Q or ubiquinone) in humans and yeast Saccharomyces cerevisiae. As one of eleven polypeptides required for Q production in yeast,
Coq5 catalyzes the only C-methylation involved in the biosynthesis of coenzyme Q (Q or ubiquinone) in humans and yeast Saccharomyces cerevisiae. As one of eleven polypeptides required for Q production in yeast,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233fcb2a4c61c6cd403f9999c45a2f30
http://hdl.handle.net/10261/129400
http://hdl.handle.net/10261/129400
