Silibinin ameliorates hepatic lipid accumulation and oxidative stress in mice with non-alcoholic steatohepatitis by regulating CFLAR-JNK pathway

Autor: Wei Xu, You Jiaojiao, Yong Chen, Yayun Liu, Ting Zhai

Publikováno v: Acta Pharmaceutica Sinica B, Vol 9, Iss 4, Pp 745-757 (2019)
Acta Pharmaceutica Sinica. B

Non-alcoholic steatohepatitis (NASH) is a chronic metabolic syndrome and the CFLAR-JNK pathway can reverse the process of NASH. Although silibinin is used for the treatment of NASH in clinical, its effect on CFLAR-JNK pathway in NASH remains unclear.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32e7ccc826a7d00426fc07ff24e9b917
https://doi.org/10.1016/j.apsb.2019.02.006

Sar1b mutant mice recapitulate gastrointestinal abnormalities associated with chylomicron retention disease

Autor: Emile Levy, Nickolas Auclair, Lena Ahmarani, Jean-François Beaulieu, Noël Peretti, Nathalie Patey, Schohraya Spahis, Alain T. Sané

Publikováno v: Journal of Lipid Research
Journal of Lipid Research, 2021, 62, pp.100085. ⟨10.1016/j.jlr.2021.100085⟩
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2021, 62, pp.100085. ⟨10.1016/j.jlr.2021.100085⟩
Journal of Lipid Research, Vol 62, Iss, Pp 100085-(2021)

International audience; Chylomicron retention disease (CRD) is an autosomal recessive disorder associated with biallelic Sar1b mutations leading to defects in intracellular chylomicron (CM) trafficking and secretion. To date, a direct cause-effect re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437c6d76490d2b00b616f9ab5275cf52
https://doi.org/10.1016/j.jlr.2021.100085

Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)

Autor: Jennifer E. Gallagher, Dorothy Kisielewski, John F. Dillon, Shaun V. Walsh, Diane Cassidy, David J. Harrison, Ritu Sharma, Tadashi Honda, John D. Hayes, Alison D. McNeilly, Michael L.J. Ashford, Albena T. Dinkova-Kostova, Rory J. McCrimmon

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 367-398 (2018)

Background & Aims Nonalcoholic steatohepatitis (NASH) is associated with oxidative stress. We surmised that pharmacologic activation of NF-E2 p45-related factor 2 (Nrf2) using the acetylenic tricyclic bis(cyano enone) TBE-31 would suppress NASH becau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebdd8de56b5ba950a8c970d72cce7012
https://doi.org/10.1016/j.jcmgh.2017.11.016

The KLB rs17618244 gene variant is associated with fibrosing MAFLD by promoting hepatic stellate cell activation

Autor: Luca Miele, Erika Paolini, Miriam Longo, Valentina D'Oria, Annalisa Crudele, Marco Maggioni, Luca Valenti, Marica Meroni, Paola Dongiovanni, Emanuele Bellacchio, Anna Alisi, Nadia Panera, Anna Ludovica Fracanzani

Publikováno v: EBioMedicine
EBioMedicine, Vol 65, Iss, Pp 103249-(2021)

Background The rs17618244 G>A β-Klotho (KLB) variant has been associated with increased risk of ballooning and inflammation in pediatric patients with metabolic associated fatty liver disease (MAFLD), by reducing KLB expression. In hepatocytes, KLB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76b73168cc030189c281702ac035f66d
https://doi.org/10.1016/j.ebiom.2021.103249

Mechanism of the development of nonalcoholic steatohepatitis after pancreaticoduodenectomy

Autor: Takahiro Yamaura, Frank J. Gonzalez, Tadanobu Nagaya, Toshifumi Aoyama, Takefumi Kimura, Naoki Tanaka, Hiroyuki Kitabatake, Kenji Sano, Michiharu Komatsu, Naoyuki Fujimori, Eiji Tanaka, Takeji Umemura, Akira Horiuchi

Publikováno v: BBA Clinical

Background and aim It is recognized that nonalcoholic fatty liver disease (NAFLD), including nonalcoholic steatohepatitis (NASH), may develop after pancreaticoduodenectomy (PD). However, the mechanism of NASH development remains unclear. This study a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f768717564a8b597fab13ab396fd8aec
https://pubmed.ncbi.nlm.nih.gov/26674248