Variations in Practice to Therapeutic Monitoring of Tacrolimus following Primary Adult Liver Transplantation

Autor: BVM Dasari, J Hodson, A Nassir, J Widmer, J Isaac, H Mergentel, P Muiesan, DF Mirza, MTPR Perera

Publikováno v: International Journal of Organ Transplantation Medicine, Vol 7, Iss 1 (2016)

Background: There is limited clinical evidence evaluating the correlation between immunosuppressant monitoring practice and transplant outcomes. Objective: To assess current practice of tacrolimus trough monitoring in early post-operative period fol

Externí odkaz: https://doaj.org/article/59a0c5f39a3f4758baa3500c5557f04d

A reproducible extended ex-vivo normothermic machine liver perfusion protocol utilising improved nutrition and targeted vascular flows.

Autor: Clarke G; Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2TH, UK. George.Clarke@uhb.nhs.uk.; Birmingham Biomedical Research Centre, National Institute for Health Research (NIHR), University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2TH, UK. George.Clarke@uhb.nhs.uk.; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TH, UK. George.Clarke@uhb.nhs.uk., Mao J; Birmingham Biomedical Research Centre, National Institute for Health Research (NIHR), University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2TH, UK.; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TH, UK., Hann A; Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2TH, UK.; Birmingham Biomedical Research Centre, National Institute for Health Research (NIHR), University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2TH, UK.; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TH, UK., Fan Y; Birmingham Biomedical Research Centre, National Institute for Health Research (NIHR), University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2TH, UK.; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TH, UK., Gupta A; Ochre-Bio Ltd, Oxford, UK., Nutu A; Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2TH, UK., Buckel Schaffner E; Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2TH, UK., Kayani K; Birmingham Biomedical Research Centre, National Institute for Health Research (NIHR), University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2TH, UK.; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TH, UK.; Queen Elizabeth Hospital Birmingham, Birmingham, B15 2TH, UK., Murphy N; Intensive Care Unit, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2TH, UK.; Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, B15 2TH, UK., Bangash MN; Intensive Care Unit, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2TH, UK.; Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, B15 2TH, UK., Casey AL; Microbiology Department, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2TH, UK., Wootton I; Clinical Biochemistry, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2TH, UK., Lawson AJ; Clinical Biochemistry, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2TH, UK., Dasari BVM; Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2TH, UK., Perera MTPR; Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2TH, UK.; Birmingham Biomedical Research Centre, National Institute for Health Research (NIHR), University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2TH, UK.; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TH, UK., Mergental H; Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2TH, UK.; Birmingham Biomedical Research Centre, National Institute for Health Research (NIHR), University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2TH, UK.; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TH, UK., Afford SC; Birmingham Biomedical Research Centre, National Institute for Health Research (NIHR), University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2TH, UK.; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TH, UK.

Publikováno v: Communications medicine [Commun Med (Lond)] 2024 Oct 24; Vol. 4 (1), pp. 214. Date of Electronic Publication: 2024 Oct 24.

Discarded livers tested by normothermic machine perfusion in the VITTAL trial: Secondary end points and 5-year outcomes.

Autor: Mergental H; Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT), Birmingham, UK.; National Institute for Health Research (NIHR), Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, UK.; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, UK., Laing RW; Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT), Birmingham, UK.; Hepato-pancreato Biliary Unit, Royal Stoke University Hospital, Stoke on Trent, UK., Kirkham AJ; Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, UK., Clarke G; National Institute for Health Research (NIHR), Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, UK.; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, UK., Boteon YL; Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT), Birmingham, UK.; Liver Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil., Barton D; D3B team, Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, UK., Neil DAH; National Institute for Health Research (NIHR), Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, UK.; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, UK.; Department of Cellular Pathology, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT), Birmingham, UK., Isaac JR; Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT), Birmingham, UK., Roberts KJ; Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT), Birmingham, UK.; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, UK., Abradelo M; Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT), Birmingham, UK.; HPB and Abdominal Organ Transplantation Department, 12 de Octubre University Hospital, Madrid, Spain., Schlegel A; Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT), Birmingham, UK.; National Institute for Health Research (NIHR), Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, UK.; Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Centre of Preclinical Research, Milan, Italy., Dasari BVM; Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT), Birmingham, UK., Ferguson JW; Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT), Birmingham, UK.; National Institute for Health Research (NIHR), Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, UK., Cilliers H; Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT), Birmingham, UK., Morris C; OrganOx Limited, Oxford, UK., Friend PJ; OrganOx Limited, Oxford, UK.; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Yap C; Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, UK.; Clinical Trials and Statistics Unit, The Institute for Cancer Research, London., Afford SC; National Institute for Health Research (NIHR), Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, UK.; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, UK., Perera MTPR; Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT), Birmingham, UK.; National Institute for Health Research (NIHR), Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, UK.; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, UK., Mirza DF; Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust (UHBFT), Birmingham, UK.; National Institute for Health Research (NIHR), Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, UK.; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, UK.

Publikováno v: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society [Liver Transpl] 2024 Jan 01; Vol. 30 (1), pp. 30-45. Date of Electronic Publication: 2023 Dec 15.

Letter to the Editor: Machine perfusion and acute rejection: Not as simple as it seems-The influence of retransplantation.

Autor: Neil DAH; Department of Cellular Pathology, Queen Elizabeth Hospital Birmingham, Birmingham, UK.; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK., Hann A; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.; Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, UK., Perera MTPR; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.; Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, UK.

Publikováno v: Hepatology (Baltimore, Md.) [Hepatology] 2023 Oct 01; Vol. 78 (4), pp. E68. Date of Electronic Publication: 2023 May 26.

Reconstruction for complex portal vein thrombosis - Anatomical if possible.

Autor: Durán M; The Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2GW, United Kingdom; Unit of Liver Transplantation, Reina Sofía University Hospital, Córdoba, 14004, Spain., Alfarah J; The Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2GW, United Kingdom., Hann A; Unit of Liver Transplantation, Reina Sofía University Hospital, Córdoba, 14004, Spain., Perera MTPR; The Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2GW, United Kingdom; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TH, United Kingdom. Electronic address: thamara.perera@uhb.nhs.uk.

Publikováno v: Journal of hepatology [J Hepatol] 2023 Sep; Vol. 79 (3), pp. e129-e131. Date of Electronic Publication: 2023 Mar 31.