Mitochondria-Rich Extracellular Vesicles Rescue Patient-Specific Cardiomyocytes From Doxorubicin Injury

Autor: Robert Sinclair, Yitian Zeng, Gentaro Ikeda, Ji Hye Jung, Christine Wahlquist, Utkan Demirci, Yunshin Jung, Nathan Bayardo, Adrian P. Gee, Connor O'Brien, Zewen Jiang, Katrin J. Svensson, Elizabeth S. Egan, Evgeniya Vaskova, Michelle R. Santoso, Phillip C. Yang, Ronald M. Witteles, Mark Mercola, Mehmet Ozgun Ozen, Liye Shi

Publikováno v: JACC: CardioOncology

Background Anthracycline-induced cardiomyopathy (AIC) is a significant source of morbidity and mortality in cancer survivors. The role of mesenchymal stem cells (MSCs) in treating AIC was evaluated in the SENECA trial, a Phase 1 National Heart, Lung,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c25d014101ed00cc5bea7576b26705
https://doi.org/10.1016/j.jaccao.2021.05.006

The Neurogenic Basic Helix-Loop-Helix Transcription Factor NeuroD6 Confers Tolerance to Oxidative Stress by Triggering an Antioxidant Response and Sustaining the Mitochondrial Biomass

Autor: Kristin K. Baxter, Anne Chiaramello, Martine Uittenbogaard

Publikováno v: ASN Neuro, Vol 2 (2010)
Scopus-Elsevier
ASN NEURO

Preserving mitochondrial mass, bioenergetic functions and ROS (reactive oxygen species) homoeostasis is key to neuronal differentiation and survival, as mitochondria produce most of the energy in the form of ATP to execute and maintain these cellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00fa9a0db409081c253decc1ee3f0eb2
https://doaj.org/article/5ce1230a326d4f43a0cc2bfdec03fd57

Mitochondria-Rich Extracellular Vesicles Rescue Patient-Specific Cardiomyocytes From Doxorubicin Injury: Insights Into the SENECA Trial.

Autor: O'Brien CG; Department of Medicine, Division of Cardiology, University California San Francisco School of Medicine, San Francisco, California, USA., Ozen MO; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, California, USA.; Bio-Acoustic MEMS in Medicine BAMM Laboratory, Canary Center at Stanford for Cancer Early Detection, Department of Radiology, Stanford School of Medicine, Stanford University, Palo Alto, California, USA., Ikeda G; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, California, USA.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA., Vaskova E; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, California, USA.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA., Jung JH; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, California, USA.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA., Bayardo N; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, California, USA.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA., Santoso MR; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, California, USA.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA., Shi L; Department of Geriatric Cardiovascular Medicine, First Hospital of China Medical University, Shenyang, Liaoning, China., Wahlquist C; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, California, USA.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA., Jiang Z; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.; Stanford Diabetes Research Center, Stanford University School of Medicine, Stanford, California, USA., Jung Y; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.; Stanford Diabetes Research Center, Stanford University School of Medicine, Stanford, California, USA., Zeng Y; Department of Materials Science and Engineering, Stanford University, Stanford, California, USA., Egan E; Department of Pediatrics (Infectious Diseases), Stanford University School of Medicine, Stanford, California, USA., Sinclair R; Department of Materials Science and Engineering, Stanford University, Stanford, California, USA., Gee A; Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA., Witteles R; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA., Mercola M; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, California, USA.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA., Svensson KJ; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.; Stanford Diabetes Research Center, Stanford University School of Medicine, Stanford, California, USA., Demirci U; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, California, USA.; Bio-Acoustic MEMS in Medicine BAMM Laboratory, Canary Center at Stanford for Cancer Early Detection, Department of Radiology, Stanford School of Medicine, Stanford University, Palo Alto, California, USA.; Department of Electrical Engineering (by courtesy), Stanford, California, USA., Yang PC; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, California, USA.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA.

Publikováno v: JACC. CardioOncology [JACC CardioOncol] 2021 Jul 27; Vol. 3 (3), pp. 428-440. Date of Electronic Publication: 2021 Jul 27 (Print Publication: 2021).

The neurogenic basic helix-loop-helix transcription factor NeuroD6 concomitantly increases mitochondrial mass and regulates cytoskeletal organization in the early stages of neuronal differentiation.

Autor: Kathleen Baxter K; Department of Anatomy and Regenerative Biology, George Washington University Medical Center, 2300 I Street N.W., Washington, DC 20037, USA., Uittenbogaard M, Yoon J, Chiaramello A

Publikováno v: ASN neuro [ASN Neuro] 2009 Sep 16; Vol. 1 (4). Date of Electronic Publication: 2009 Sep 16.