Directed Evolution of an EnantioselectiveBacillus subtilisLipase

Autor: BW Dijkstra, Karl-Erich Jaeger, Walter Thiel, Bauke W. Dijkstra, KE Jaeger, Andreas Eipper, T Eggert, Nikolaj Otte, Susanne Aileen Funke, G. Van Pouderoyen, Manfred T. Reetz, SA Funke, MT Reetz

Publikováno v: Biocatalysis and Biotransformation, 21(2), 67-73

Chiral compounds are of steadily increasing importance to the chemical industry, in particular for the production of pharmaceuticals. Where do these compounds come from? Apart from natural resources, two synthetic strategies are available: asymmetric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13906534991d0e2e3a5f1ca4d5e26cb5
https://doi.org/10.1080/1024242031000110847

Breakthrough in the chemoenzymatic transformation of CO 2 for the sustainable artificial synthesis of hexoses with complete control of stereochemistry.

Autor: Reetz MT; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China; Biocatalysis Section, Max-Planck-Institut für Kohlenforschung, Mülheim an der Ruhr 45470, Germany. Electronic address: reetz@mpi-muelheim.mpg.de.

Publikováno v: Science bulletin [Sci Bull (Beijing)] 2023 Oct 30; Vol. 68 (20), pp. 2291-2292. Date of Electronic Publication: 2023 Aug 25.

Rational enzyme design for enabling biocatalytic Baldwin cyclization and asymmetric synthesis of chiral heterocycles.

Autor: Li JK; Department of Chemistry, Frontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin, 300072, China.; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China., Qu G; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.; National Technology Innovation Center of Synthetic Biology, Tianjin, 300308, China., Li X; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.; National Technology Innovation Center of Synthetic Biology, Tianjin, 300308, China., Tian Y; Department of Chemistry, Frontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin, 300072, China., Cui C; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.; National Technology Innovation Center of Synthetic Biology, Tianjin, 300308, China., Zhang FG; Department of Chemistry, Frontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin, 300072, China., Zhang W; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.; National Technology Innovation Center of Synthetic Biology, Tianjin, 300308, China., Ma JA; Department of Chemistry, Frontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin, 300072, China. majun_an68@tju.edu.cn., Reetz MT; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China. reetz@mpi-muelheim.mpg.de.; Biocatalysis Section, Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470, Mülheim an der Ruhr, Germany. reetz@mpi-muelheim.mpg.de., Sun Z; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China. sunzht@tib.cas.cn.; National Technology Innovation Center of Synthetic Biology, Tianjin, 300308, China. sunzht@tib.cas.cn.

Publikováno v: Nature communications [Nat Commun] 2022 Dec 19; Vol. 13 (1), pp. 7813. Date of Electronic Publication: 2022 Dec 19.

Publisher Correction: A machine learning approach for reliable prediction of amino acid interactions and its application in the directed evolution of enantioselective enzymes.

Autor: Cadet F; PEACCEL, Protein Engineering Accelerator, Paris, France. frederic.cadet@peaccel.com., Fontaine N; PEACCEL, Protein Engineering Accelerator, Paris, France., Li G; Department of Chemistry, Philipps-University, 35032, Marburg, Germany., Sanchis J; Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Australia., Chong MNF; PEACCEL, Protein Engineering Accelerator, Paris, France., Pandjaitan R; PEACCEL, Protein Engineering Accelerator, Paris, France., Vetrivel I; PEACCEL, Protein Engineering Accelerator, Paris, France., Offmann B; UFIP, UMR 6286 CNRS, UFR Sciences et Techniques, Université de Nantes, Nantes, France., Reetz MT; Department of Chemistry, Philipps-University, 35032, Marburg, Germany.; Max-Planck-Institut Fuer Kohlenforschung, 45470, Mülheim, Germany.

Publikováno v: Scientific reports [Sci Rep] 2021 Apr 12; Vol. 11 (1), pp. 8357. Date of Electronic Publication: 2021 Apr 12.

Machine Learning Enables Selection of Epistatic Enzyme Mutants for Stability Against Unfolding and Detrimental Aggregation.

Autor: Li G; State Key Laboratory for Biology of Plant Diseases and Insect Pests Key Laboratory of Control of Biological Hazard Factors (Plant Origin) for Agri-product Quality and Safety Ministry of Agriculture, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100081, P. R. China., Qin Y; State Key Laboratory for Biology of Plant Diseases and Insect Pests Key Laboratory of Control of Biological Hazard Factors (Plant Origin) for Agri-product Quality and Safety Ministry of Agriculture, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100081, P. R. China., Fontaine NT; PEACCEL, Artificial Intelligence Department, 6 Square Albin Cachot, Box 42, 75013, Paris, France) ., Ng Fuk Chong M; PEACCEL, Artificial Intelligence Department, 6 Square Albin Cachot, Box 42, 75013, Paris, France) ., Maria-Solano MA; Institut de Química Computacional i Catàlisi and Departament de Química, Universitat de Girona Campus Montilivi, 17003, Girona, Catalonia, Spain) ., Feixas F; Institut de Química Computacional i Catàlisi and Departament de Química, Universitat de Girona Campus Montilivi, 17003, Girona, Catalonia, Spain) ., Cadet XF; PEACCEL, Artificial Intelligence Department, 6 Square Albin Cachot, Box 42, 75013, Paris, France) ., Pandjaitan R; PEACCEL, Artificial Intelligence Department, 6 Square Albin Cachot, Box 42, 75013, Paris, France) ., Garcia-Borràs M; Institut de Química Computacional i Catàlisi and Departament de Química, Universitat de Girona Campus Montilivi, 17003, Girona, Catalonia, Spain) ., Cadet F; PEACCEL, Artificial Intelligence Department, 6 Square Albin Cachot, Box 42, 75013, Paris, France) ., Reetz MT; Department of Chemistry, Philipps-Universität, 35032, Marburg, Germany) .; Max-Planck-Institut fuer Kohlenforschung, 45470, Mülheim, Germany.; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 West 7th Avenue, Tianjin Airport Economic Area, 300308, Tianjin, P. R. China.

Publikováno v: Chembiochem : a European journal of chemical biology [Chembiochem] 2021 Mar 02; Vol. 22 (5), pp. 904-914. Date of Electronic Publication: 2020 Nov 17.