Zobrazeno 1 - 10
of 180
pro vyhledávání: '"MT: bioinformatics"'
Autor:
Lina Bu, Shaodong Huang, Ziyan Rao, Chenyang Wu, Bryan-Yu Sun, Yanhua Liu, Lin He, Dongyu Zhao
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102397- (2024)
CHD6, a member of the chromodomain helicase DNA-binding protein family, has been implicated in various diseases and tumors. However, its precise binding model of CHD6 on regulatory functional genes remains poorly understood. In this study, we discove
Externí odkaz:
https://doaj.org/article/0e77b9326ac941caadfdc8a3dee3b68b
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102370- (2024)
Prime editors are CRISPR-based genome engineering tools with significant potential for rectifying patient mutations. However, their usage requires experimental optimization of the prime editing guide RNA (PegRNA) to achieve high editing efficiency. T
Externí odkaz:
https://doaj.org/article/be68ede751734db5b4fc4670d92ad429
Autor:
Rong Xia, Xiangyu Yin, Jiaming Huang, Kunqi Chen, Jiongming Ma, Zhen Wei, Jionglong Su, Neil Blake, Daniel J. Rigden, Jia Meng, Bowen Song
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102376- (2024)
Cancer is a complex and multifaceted group of diseases characterized by uncontrolled cell growth that leads to the formation of malignant tumors. Recent studies suggest that N6-methyladenosine (m6A) RNA methylation plays pivotal roles in cancer patho
Externí odkaz:
https://doaj.org/article/da176ee8742f429abfdbe1de4a69633b
Autor:
Dario Ruiz-Ciancio, Suresh Veeramani, Rahul Singh, Eric Embree, Chris Ortman, Kristina W. Thiel, William H. Thiel
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102358- (2024)
Aptamers are short single-stranded DNA or RNA molecules with high affinity and specificity for targets and are generated using the iterative systematic evolution of ligands by exponential enrichment (SELEX) process. Next-generation sequencing (NGS) r
Externí odkaz:
https://doaj.org/article/cc384644dd5d4f4c99c131eb63f2311c
Autor:
Chiara Africano, Tiziana Bachetti, Paolo Uva, Gabriel Pitollat, Genny Del Zotto, Francesca Giacopelli, Giada Recchi, Nicolas Lenfant, Amélia Madani, Nathan Beckouche, Muriel Thoby-Brisson, Isabella Ceccherini
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102319- (2024)
Congenital central hypoventilation syndrome (CCHS), a rare genetic disease caused by heterozygous PHOX2B mutations, is characterized by life-threatening breathing deficiencies. PHOX2B is a transcription factor required for the specification of the au
Externí odkaz:
https://doaj.org/article/23bd66697de441dbbe708623068110a6
Autor:
Xia Wu, Mengxin Chen, Kang Liu, Yixin Wu, Yun Feng, Shiting Fu, Huaimeng Xu, Yongqi Zhao, Feilong Lin, Liang Lin, Shihui Ye, Junqiang Lin, Taiping Xiao, Wenhao Li, Meng Lou, Hongyu Lv, Ye Qiu, Ruifan Yu, Wenyan Chen, Mengyuan Li, Xu Feng, Zhongbing Luo, Lu Guo, Hao Ke, Limin Zhao
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102309- (2024)
Breast cancer in the elderly presents distinct biological characteristics and clinical treatment responses compared with cancer in younger patients. Comprehensive Geriatric Assessment is recommended for evaluating treatment efficacy in elderly cancer
Externí odkaz:
https://doaj.org/article/ad36089f2476458595f167bfffa4c495
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 3, Pp 102295- (2024)
Due to the transformation of artificial intelligence (AI) tools and technologies, AI-driven drug discovery has come to the forefront. It reduces the time and expenditure. Due to these advantages, pharmaceutical industries are concentrating on AI-driv
Externí odkaz:
https://doaj.org/article/58e74a7404244aa2a9ac2685f88b84a9
Publikováno v:
In Molecular Therapy - Nucleic Acids 11 March 2025 36(1)
Autor:
Philip Prathipati, Anup S. Pathania, Nagendra K. Chaturvedi, Subash C. Gupta, Siddappa N. Byrareddy, Don W. Coulter, Kishore B. Challagundla
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 101543- (2024)
Neuroblastoma is the most devastating extracranial solid malignancy in children. Despite an intense treatment regimen, the prognosis for high-risk neuroblastoma patients remains poor, with less than 40% survival. So far, MYCN amplification status is
Externí odkaz:
https://doaj.org/article/7d9eb9261b3e4d0b860be7a5cf90ac13
Autor:
Xiaodie Liu, Wenhui Wang, Xiaolei Zhang, Jing Liang, Dingqing Feng, Yuebo Li, Ming Xue, Bin Ling
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102155- (2024)
Endometrial cancer (EC), the second most common malignancy in the female reproductive system, has garnered increasing attention for its genomic heterogeneity, but understanding of its metabolic characteristics is still poor. We explored metabolic dys
Externí odkaz:
https://doaj.org/article/fb4bf2e2222640f0a647289b7b65e6ef