Zobrazeno 1 - 10
of 15
pro vyhledávání: '"MSU, monosodium urate"'
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2880-2899 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2880-2899 (2021)
Aberrant activation of NLRP3 inflammasome in colonic macrophages strongly associates with the occurrence and progression of ulcerative colitis. Although targeting NLRP3 inflammasome has been considered to be a potential therapy, the underlying mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b197d7e1bd61447a9d7a45da0a56387
https://doi.org/10.1016/j.apsb.2021.03.011
https://doi.org/10.1016/j.apsb.2021.03.011
Autor:
Oksana Mykhailivna Tarasenko, Olena Myroslavivna Karmazina, Valentyn Valentinovich Taranchuk, V Kondratiuk
Publikováno v:
Journal of Medicine and Life
The main goal of our study is the impact evaluation of complex urate-lowering therapy with the synbiotic addition on fecal microbiota and cytokine profile in patients with primary gout. During our study, 130 men (mean age 55.5 ± 9.4 years) with gout
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a03441155b0a2b745285399c907ef3db
https://doi.org/10.25122/jml-2020-0065
https://doi.org/10.25122/jml-2020-0065
Autor:
Andras Perl, Christian Geier
Publikováno v:
Autoimmunity Reviews
The mechanistic target of rapamycin (mTOR) pathway integrates metabolic cues into cell fate decisions. A particularly fateful event during the adaptive immune response is the engagement of a T cell receptor by its cognate antigen presented by an anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3990d80b30d059d40d16ba75850ac283
https://pubmed.ncbi.nlm.nih.gov/34718162
https://pubmed.ncbi.nlm.nih.gov/34718162
Autor:
Byung-Cheol Han, Huijeong Ahn, Seung Ho Lee, Pyeung-Hyeun Kim, Seung Goo Kang, Geun-Shik Lee, Jeongeun Kim, Kyoung Hwa Jang, Seung Ho So
Publikováno v:
Journal of Ginseng Research
Journal of Ginseng Research, Vol 43, Iss 2, Pp 291-299 (2019)
Journal of Ginseng Research, Vol 43, Iss 2, Pp 291-299 (2019)
Background: Ginsenosides of Korean Red Ginseng extracts (RGE) and its saponin components suppress secretion of inflammasome-mediating cytokines, whereas the nonsaponin fraction (NS) of RGE oppositely stimulates cytokine secretion. Although direct exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01ab129d7472b81a4848b3e801339a7
https://doi.org/10.1016/j.jgr.2018.03.003
https://doi.org/10.1016/j.jgr.2018.03.003
Autor:
Shengbing Yang, Hanjun Li, Jingtian Mei, Han Qiao, Feng Zhou, Minqi Wang, Linyang Chu, Tingting Tang, Xiuguo Han
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 973-985 (2019)
Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 973-985 (2019)
The objective was to investigate the effect of kinsenoside (Kin) treatments on macrophage polarity and evaluate the resulting protection of chondrocytes to attenuate osteoarthritis (OA) progression. RAW264.7 macrophages were polarized to M1/M2 subtyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::657da9eb0531d9727733222372f40b72
http://europepmc.org/articles/PMC6804452
http://europepmc.org/articles/PMC6804452
Extracellular cathepsin Z signals through the α5 integrin and augments NLRP3 inflammasome activation
Autor:
Justin A. MacDonald, Catherine J. Greene, Christina F. Sandall, Neil McKenna, Rhiannon I. Campden, Jose A. Chiriboga, Robin M. Yates, Devin Aggarwal, Amy L. Warren, Corey R. Arnold
Publikováno v:
The Journal of Biological Chemistry
Respiratory silicosis is a preventable occupational disease that develops secondary to the aspiration of crystalline silicon dioxide (silica) into the lungs, activation of the NLRP3 inflammasome, and IL-1β production. Cathepsin Z has been associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b27c210c61616d4955d5ffecfb0fa14
https://doi.org/10.1016/j.jbc.2021.101459
https://doi.org/10.1016/j.jbc.2021.101459
Autor:
Chengyuan Tang, Xiaofen Xiong, Xiaoxuan Xu, Lin Sun, Shuguang Yuan, Yachun Han, Xianghui Chen, Shikun Yang, Yashpal S. Kanwar, Fuyou Liu, Xuejing Zhu, Ming Yang, Li Xiao, Peng Gao
Publikováno v:
Redox Biology
Redox Biology, Vol 16, Iss, Pp 32-46 (2018)
Redox Biology, Vol 16, Iss, Pp 32-46 (2018)
NLRP3/IL-1β activation via thioredoxin (TRX)/thioredoxin-interacting protein (TXNIP) following mitochondria ROS (mtROS) overproduction plays a key role in inflammation. However, the involvement of this process in tubular damage in the kidneys of pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb01cc8d366dba9d9e8efe1eccaf3915
http://europepmc.org/articles/PMC5842313
http://europepmc.org/articles/PMC5842313
Autor:
Matthias Epple, Yana Dautova, Kevin Pappert, Alexander N. Kapustin, Martin D. Bootman, Hanneke Okkenhaug, Diane Proudfoot, Simon J. Cook, Catherine M. Shanahan
Publikováno v:
Journal of Molecular and Cellular Cardiology
Dautova, Y, Kapustin, A, Pappert, K, Epple, M, Okkenhaug, H, Cook, S J, Shanahan, C M, Bootman, M D & Proudfoot, D 2017, ' Calcium phosphate particles stimulate interleukin-1β release from human vascular smooth muscle cells : A role for spleen tyrosine kinase and exosome release ', Journal of Molecular and Cellular Cardiology . https://doi.org/10.1016/j.yjmcc.2017.12.007
Dautova, Y, Kapustin, A, Pappert, K, Epple, M, Okkenhaug, H, Cook, S J, Shanahan, C M, Bootman, M D & Proudfoot, D 2017, ' Calcium phosphate particles stimulate interleukin-1β release from human vascular smooth muscle cells : A role for spleen tyrosine kinase and exosome release ', Journal of Molecular and Cellular Cardiology . https://doi.org/10.1016/j.yjmcc.2017.12.007
Aims Calcium phosphate (CaP) particle deposits are found in several inflammatory diseases including atherosclerosis and osteoarthritis. CaP, and other forms of crystals and particles, can promote inflammasome formation in macrophages leading to caspa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d86e001074dcd1dcf16d9ed519a5db8
http://europepmc.org/articles/PMC5823844
http://europepmc.org/articles/PMC5823844
Autor:
Misha Zarbafian, Jan P. Dutz
Publikováno v:
JAAD Case Reports, Vol 3, Iss 1, Pp 45-48 (2017)
JAAD Case Reports
JAAD Case Reports
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0845c24bd96d342b4ac774b54812580
https://doi.org/10.1016/j.jdcr.2016.10.013
https://doi.org/10.1016/j.jdcr.2016.10.013
Autor:
Fischer S; Institute for Immunology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, 30559 Hannover, Germany., Stegmann F; Institute for Immunology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, 30559 Hannover, Germany., Gnanapragassam VS; Institute for Immunology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, 30559 Hannover, Germany., Lepenies B; Institute for Immunology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
Publikováno v:
Computational and structural biotechnology journal [Comput Struct Biotechnol J] 2022 Oct 20; Vol. 20, pp. 5790-5812. Date of Electronic Publication: 2022 Oct 20 (Print Publication: 2022).