Zobrazeno 1 - 10
of 3 153
pro vyhledávání: '"MSH6"'
Autor:
Sidhartha Singh, Navneet Singh, Parth Sarthi Sen Gupta, Saroj Kumar Panda, Isha Dhamija, Deepak Nathiya, Sandeep Kumar, Siddharth Sharma
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract The present study investigated the relationship between MSH3 and MSH6 genes in lung cancer patients. Genotyping of lung cancer patients and healthy controls was performed. Odds ratio values were calculated and survival analysis performed. Pa
Externí odkaz:
https://doaj.org/article/3a732f22f1b143b88fd6a027c75b199c
Publikováno v:
Indian Journal of Radiology and Imaging, Vol 34, Iss 03, Pp 562-565 (2024)
Constitutional mismatch repair deficiency (CMMRD) is a rare childhood cancer predisposition syndrome that results from biallelic germline mutations in one of the four MMR genes, MLH1, MSH2, MSH6, or PMS2. This syndrome is characterized by a broad spe
Externí odkaz:
https://doaj.org/article/e35394ce735d48e5ba1e02c2230077bc
Autor:
Pål Møller, Saskia Haupt, Aysel Ahadova, Matthias Kloor, Julian R. Sampson, Lone Sunde, Toni Seppälä, John Burn, Inge Bernstein, Gabriel Capella, D. Gareth Evans, Annika Lindblom, Ingrid Winship, Finlay Macrae, Lior Katz, Ido Laish, Elez Vainer, Kevin Monahan, Elizabeth Half, Karoline Horisberger, Leandro Apolinário da Silva, Vincent Heuveline, Christina Therkildsen, Charlotte Lautrup, Louise L Klarskov, Giulia Martina Cavestro, Gabriela Möslein, Eivind Hovig, Mev Dominguez-Valentin
Publikováno v:
Hereditary Cancer in Clinical Practice, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Background Colorectal cancers (CRCs) in the Lynch syndromes have been assumed to emerge through an accelerated adenoma-carcinoma pathway. In this model adenomas with deficient mismatch repair have an increased probability of acquiring additi
Externí odkaz:
https://doaj.org/article/b927da2164d549d2a1b8caf236ddd5ed
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Lynch syndrome, a hereditary cancer susceptibility syndrome, arises from pathogenic mutations in mismatch repair genes. This syndrome is strongly linked to colorectal and endometrial cancers, as well as an elevated risk for other cancers such as gast
Externí odkaz:
https://doaj.org/article/13b3b40d64874708a1f3eb21066f9581
Publikováno v:
Biomedical Papers, Vol 168, Iss 1, Pp 68-73 (2024)
Aims. To investigate DNA methylation of specific gene promoters in endometrial hyperplasia compared to normal endometrial tissue. Materials and Methods. To search for epigenetic events, methylation-specific multiplex ligation-dependent probe amplific
Externí odkaz:
https://doaj.org/article/a3ae070db5d1468d9e96c6b5bfbb7f49
Autor:
Nooshin Nazarinejad, Bahareh Hajikhani, Amir Abbas Vaezi, Farzaneh Firoozeh, Fatemeh Sameni, Somayeh Yaslianifard, Mehdi Goudarzi, Masoud Dadashi
Publikováno v:
BMC Gastroenterology, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background Deficient DNA mismatch repair (MMR) can cause microsatellite instability (MSI) and is more common in colorectal cancer (CRC) patients. Understanding the carcinogenic mechanism of bacteria and their impact on cancer cells is crucia
Externí odkaz:
https://doaj.org/article/2283b0f5b477476bbaca7f846fa906d8
Autor:
Zijun Y. Xu-Monette, Cancan Luo, Li Yu, Yong Li, Govind Bhagat, Alexandar Tzankov, Carlo Visco, Xiangshan Fan, Karen Dybkaer, Ali Sakhdari, Nicholas T. Wang, Alyssa F. Yuan, April Chiu, Wayne Tam, Youli Zu, Eric D. Hsi, Anamarija M. Perry, Wenting Song, Dennis O’Malley, Qingyan Au, Harry Nunns, Heounjeong Go, Michael B. Møller, Benjamin M. Parsons, Santiago Montes-Moreno, Maurilio Ponzoni, Andrés J.M. Ferreri, Aliyah R. Sohani, Jeremy S. Abramson, Bing Xu, Ken H. Young
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
Deficient (d) DNA mismatch repair (MMR) is a biomarker predictive of better response to PD-1 blockade immunotherapy in solid tumors. dMMR can be caused by mutations in MMR genes or by protein inactivation, which can be detected by sequencing and immu
Externí odkaz:
https://doaj.org/article/5de2138da31648e09e4ad55f932a3cf2
Publikováno v:
Biotechnology & Biotechnological Equipment, Vol 38, Iss 1 (2024)
AbstractColorectal cancer is one of the most common cancers and a frequent cause of mortality and morbidity. In this study, we aimed to investigate the Mismatch Repair (MMR) gene products of colorectal adenocarcinomas by immunohistochemistry, to inve
Externí odkaz:
https://doaj.org/article/4f6d3937e47242cf929c18cf4a57931c
Autor:
Yi-Ching Huang, Peng-Chan Lin, Pei-Ying Wu, Nai-Syuan Chen, Meng-Ru Shen, Yu-Min Yeh, Ya-Min Cheng
Publikováno v:
Gynecologic Oncology Reports, Vol 53, Iss , Pp 101381- (2024)
Introduction: Lynch syndrome is caused by a germline mutation in mismatch repair (MMR) genes, leading to the loss of expression of MMR heterodimers, either MLH1/PMS2 or MSH2/MSH6, or isolated loss of PMS2 or MSH6. Concurrent loss of both heterodimers
Externí odkaz:
https://doaj.org/article/e2818d5f063a4540be45c05cb287877c
Publikováno v:
Cancer Treatment and Research Communications, Vol 40, Iss , Pp 100826- (2024)
Background: Recently, some evidence emphasized the value of MSH2 and MSH6 inactivation and their hypermutation in predicting different cancers. The present consideration is to evaluate the value of MSH2 and MSH6 protein deficient studied by the immun
Externí odkaz:
https://doaj.org/article/f41982c74328400e8b9387ccf3663af0