Zobrazeno 1 - 10
of 28
pro vyhledávání: '"MSA, multiple sequence alignment"'
Autor:
Nurit Livnat-Levanon, Nir Ben-Tal, Elena Vigonsky, Amy C. Rosenzweig, Rose C. Hadley, Jessica Rose, Oded Lewinson, Gal Masrati, Daniel Zhitnitsky
Publikováno v:
The Journal of Biological Chemistry
The Escherichia coli yobA–yebZ–yebY (AZY) operon encodes the proteins YobA, YebZ, and YebY. YobA and YebZ are homologs of the CopC periplasmic copper-binding protein and the CopD putative copper importer, respectively, whereas YebY belongs to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba8ff10957a16317cb12cd0ca39a6a7
http://europepmc.org/articles/PMC8689200
http://europepmc.org/articles/PMC8689200
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 297 (2), pp.100913. ⟨10.1016/j.jbc.2021.100913⟩
The Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 297 (2), pp.100913. ⟨10.1016/j.jbc.2021.100913⟩
The Journal of Biological Chemistry
Trypanosomatid parasites are responsible for various human diseases, such as sleeping sickness, animal trypanosomiasis, or cutaneous and visceral leishmaniases. The few available drugs to fight related parasitic infections are often toxic and present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dacf02e49230ad2b20b5f2b86b5dbdfc
https://hal.archives-ouvertes.fr/hal-03365770
https://hal.archives-ouvertes.fr/hal-03365770
Autor:
Helena Rebelo-de-Andrade, Marta Gíria, João M. Trigueiro-Louro, Vanessa Correia, Inês Figueiredo-Nunes
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 2117-2131 (2020)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
Highlights • Human SARSr-CoV Spike protein is highly conserved in both S1 and S2 subunits. • The S1-RBD, -SD1; S2-CR, -HR1 and -CH are the most promising druggable S regions. • 28 main consensus druggable pockets were fo
Highlights • Human SARSr-CoV Spike protein is highly conserved in both S1 and S2 subunits. • The S1-RBD, -SD1; S2-CR, -HR1 and -CH are the most promising druggable S regions. • 28 main consensus druggable pockets were fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c63598730c179325ddc5c9d3b95a8608
http://www.sciencedirect.com/science/article/pii/S2001037020303494
http://www.sciencedirect.com/science/article/pii/S2001037020303494
Autor:
Ioannis A. Tamposis, Panagiota I. Kontou, Dimitra Sarantopoulou, Pantelis G. Bagos, Konstantinos D. Tsirigos, Margarita C. Theodoropoulou, Evangelia A. Stasi
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 6090-6097 (2021)
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 6090-6097 (2021)
Graphical abstract
Highlights • A method that combines HMMs and Neural Networks for biological sequence analysis. • The updated versions of PRED-TMBB2 and HMM-TM outperform the currently available methods. • The JUCHMME library – an open
Highlights • A method that combines HMMs and Neural Networks for biological sequence analysis. • The updated versions of PRED-TMBB2 and HMM-TM outperform the currently available methods. • The JUCHMME library – an open
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dae409373656d2ce9e5e0ceb3328950a
https://pubmed.ncbi.nlm.nih.gov/34849210
https://pubmed.ncbi.nlm.nih.gov/34849210
Autor:
Luis Sanchez-Pulido, Chris P. Ponting
Publikováno v:
Journal of Molecular Biology
Graphical abstract
Highlights • Co-evolution-based methods extend the homology detection horizon of protein sequence analysis. • Predicted contact maps help predict domain boundaries and tertiary structures. • Such maps also aid in identif
Highlights • Co-evolution-based methods extend the homology detection horizon of protein sequence analysis. • Predicted contact maps help predict domain boundaries and tertiary structures. • Such maps also aid in identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57b7b22b0a7a1c8f7a6773bc0dd7d6b6
https://pubmed.ncbi.nlm.nih.gov/34139218
https://pubmed.ncbi.nlm.nih.gov/34139218
Autor:
Alisdair R. Fernie, Federico Scossa
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 1579-1594 (2021)
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 1579-1594 (2021)
Graphical abstract
Highlights • ASR allows to explore the distant past in gene sequence space. • We provide a primer for non-experts to reconstruct the sequence of an extinct gene. • ASR, GWAS and fitness landscapes explore molecular evolu
Highlights • ASR allows to explore the distant past in gene sequence space. • We provide a primer for non-experts to reconstruct the sequence of an extinct gene. • ASR, GWAS and fitness landscapes explore molecular evolu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe12db7f633ec9a8ce8303182f5446d8
https://pubmed.ncbi.nlm.nih.gov/33868595
https://pubmed.ncbi.nlm.nih.gov/33868595
Publikováno v:
The Journal of Biological Chemistry
The δ-proteobacteria Myxococcus xanthus displays Social (S) and Adventurous (A) motilities, which require pole-to-pole reversal of the motility regulator proteins. Mutual gliding motility protein C (MglC), a paralog of GTPase-Activating Protein Mutu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2ccb9b91c770c6f8e4211d920ee9bc
http://europepmc.org/articles/PMC7949163
http://europepmc.org/articles/PMC7949163
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 699-711 (2019)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Protein-protein interaction (PPI) is an essential mechanism by which proteins perform their biological functions. For globular proteins, the molecular characteristics of such interactions have been well analyzed, and many computational tools are avai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3823f076e75032c853f75bb7125650
http://www.sciencedirect.com/science/article/pii/S200103701930039X
http://www.sciencedirect.com/science/article/pii/S200103701930039X
Autor:
Moti Grupper, Nir Ben-Tal, Adan Baloum, Elena Vigonsky, Nurit Livnat-Levanon, Oded Lewinson, Douglas C. Rees, Gal Masrati, Jessica Rose, Janet G. Yang, Anastasiya Kuznetsova
Publikováno v:
The Journal of Biological Chemistry
All extant life forms require trace transition metals (e.g., Fe^(2/3+), Cu^(1/2+), and Mn^(2+)) to survive. However, as these are environmentally scarce, organisms have evolved sophisticated metal uptake machineries. In bacteria, high-affinity import
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e998c6ad3716158abb4838a5d091b099
https://doi.org/10.1016/j.jbc.2021.101087
https://doi.org/10.1016/j.jbc.2021.101087
Autor:
Gregg T. Beckham, Brent Harrison, Japheth E. Gado, Mats Sandgren, Christina M. Payne, Jerry Ståhlberg
Publikováno v:
The Journal of Biological Chemistry
Family 7 glycoside hydrolases (GH7) are among the principal enzymes for cellulose degradation in nature and industrially. These important enzymes are often bimodular, comprised of a catalytic domain attached to a carbohydrate binding module (CBM) via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78bd51e315c2a523d356bdbb0e8d6356
https://doi.org/10.1016/j.jbc.2021.100931
https://doi.org/10.1016/j.jbc.2021.100931