Výsledky vyhledávání - "MRM, multiple reaction monitoring"

Akademický článek

Second generation multiple reaction monitoring assays for enhanced detection of ultra-low abundance Mycobacterium tuberculosis peptides in human serum

Autor: Carolina Mehaffy, Karen M. Dobos, Payam Nahid, Nicole A. Kruh-Garcia

Publikováno v: Clinical Proteomics, Vol 14, Iss 1, Pp 1-10 (2017)

Abstract Background Mycobacterium tuberculosis (Mtb) is the causative agent of Tuberculosis (TB), the number one cause of death due to an infectious disease. TB diagnosis is performed by microscopy, culture or PCR amplification of bacterial DNA, all

Externí odkaz: https://doaj.org/article/86f40a8e606e470b90bd1a4c091ae1b4

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Intranasal temperature-sensitive hydrogels of cannabidiol inclusion complex for the treatment of post-traumatic stress disorder

Autor: Lulu Pang, Siqing Zhu, Yiguang Jin, Jinqiu Ma, Ruiteng Li, Yijing Liu, Yaxin Wang, Lin Zhu, Yi Liang, Lina Du, Xu Jin, Ge Ou

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 2031-2047 (2021)
Acta Pharmaceutica Sinica. B

Post-traumatic stress disorder (PTSD) is a psychiatric disease that seriously affects brain function. Currently, selective serotonin reuptake inhibitors (SSRIs) are used to treat PTSD clinically but have decreased efficiency and increased side effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3acddd8c0edd4a737ab5bd19ff02fe7
http://www.sciencedirect.com/science/article/pii/S2211383521000150

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Analysis of 2-methylcitric acid, methylmalonic acid, and total homocysteine in dried blood spots by LC-MS/MS for application in the newborn screening laboratory: A dual derivatization approach

Autor: Bojana Rakic, Hilary Vallance, Joshua A. Dubland, Graham Sinclair

Publikováno v: Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 20, Iss, Pp 1-10 (2021)
Journal of Mass Spectrometry and Advances in the Clinical Lab

Highlights • Analysis of 2-methylcitric acid, methylmalonic acid, and homocysteine in DBS. • A dual derivatization LC-MS/MS strategy developed for use in second-tier NBS. • Second-tier panel replaces multiple initial follow-up tests. • Improv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50beebd48c7a916d499a13356b9284c0
https://doi.org/10.1016/j.jmsacl.2021.03.001

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Prebiotics enhance the biotransformation and bioavailability of ginsenosides in rats by modulating gut microbiota

Autor: Jun Chen, An Liu, Shuiming Xiao, Shaojing Li, Jiang Xu, Feipeng Duan, Xiaoyan Zhang, Sha Chen, Wen Zhong, Wei Sheng

Publikováno v: Journal of Ginseng Research
Journal of Ginseng Research, Vol 45, Iss 2, Pp 334-343 (2021)

Background: Gut microbiota mainly function in the biotransformation of primary ginsenosides into bioactive metabolites. Herein, we investigated the effects of three prebiotic fibers by targeting gut microbiota on the metabolism of ginsenoside Rb1 in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88acbad90b2418a8feff719b2ea047b6
https://doi.org/10.1016/j.jgr.2020.08.001

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Functional metabolomics reveal the role of AHR/GPR35 mediated kynurenic acid gradient sensing in chemotherapy-induced intestinal damage

Autor: Chuyao Liao, Di Wang, Ying Zhang, Zunjian Zhang, Fengguo Xu, Siyuan Qin, Yuxin Zhang, Danting Li, Yuan Tian, Jie Chen

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 763-780 (2021)
Acta Pharmaceutica Sinica. B

Intestinal toxicity induced by chemotherapeutics has become an important reason for the interruption of therapy and withdrawal of approved agents. In this study, we demonstrated that chemotherapeutics-induced intestinal damage were commonly character

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af930bc5ea3c9fbae9d582539b35a5f
https://doi.org/10.1016/j.apsb.2020.07.017

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Developing a robust, fast and reliable measurement method for the analysis of methylarginine derivatives and related metabolites

Autor: Ali Unlu, Sedat Abusoglu, Gulsum Abusoglu, Havva Yaglioglu, Duygu Eryavuz Onmaz

Publikováno v: Journal of Mass Spectrometry and Advances in the Clinical Lab
Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 19, Iss, Pp 34-45 (2021)

Background Nitric oxide (NO) plays an important role in endothelial homeostasis. Asymmetric dimethyl arginine (ADMA), L-N monomethyl arginine (L-NMMA) and symmetric dimethyl arginine (SDMA), which are derivatives of methylarginine, directly or indire

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2055d3fbb4930fa6ebe6940f0dd56ef
http://europepmc.org/articles/PMC8601011

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Neonicotinoid residues in commercial Japanese tea leaves produced by organic and conventional farming methods

Autor: Takahiro Ichise, Shouta M.M. Nakayama, Collins Nimako, Yoshinori Ikenaka, Kazutoshi Fujioka, Kumiko Taira, Anri Hirai, Osei Akoto, Mayumi Ishizuka

Publikováno v: Toxicology Reports, Vol 8, Iss, Pp 1657-1664 (2021)
Toxicology Reports

Graphical abstract
The current study sought to assess the residual levels of neonicotinoid insecticides (NEO) in organic and conventional green tea leaves produced in Japan. A total of 103 tea leaves (thus, 42 organic and 61 conventional), were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a264063e850ad8f4d66d6e87b287f256
http://hdl.handle.net/2115/83757

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A proposal for score assignment to characterize biological processes from mass spectral analysis of serum

Autor: Sabine Kasimir-Bauer, Harvey I. Pass, Carlos R. Oliveira, Jeffrey S. Weber, Joanna Roder, Julia Grigorieva, Senait Asmellash, Lelia Net, Heinrich Roder, Krista Meyer

Publikováno v: Clinical Mass Spectrometry

Highlights • Biological process-associated scores generated from mass spectrometry of serum. • Scores demonstrated acceptable levels of reproducibility. • Scores associated with biological processes and clinical outcome in cancer patients. •

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb17087bced93029b562d59cf79c8bfc
http://europepmc.org/articles/PMC8601010

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Design, synthesis and pharmacological evaluation of 4-(3-chloro-4-(3-cyclopropylthioureido)-2-fluorophenoxy)-7-methoxyquinoline-6-carboxamide (WXFL-152): a novel triple angiokinase inhibitor for cancer therapy

Autor: Zhuowei Liu, Yuxi Wang, Chengjian Zhao, Yang Zhang, Manyu Zhao, Jinliang Yang, Yuqin Yao, Peng Li, Chen Zhengxia, Xiaoxin Chen, Chaofeng Long

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1453-1475 (2020)

Angiokinases, such as vascular endothelial-, fibroblast- and platelet-derived growth factor receptors (VEGFRs, FGFRs and PDGFRs) play crucial roles in tumor angiogenesis. Anti-angiogenesis therapy using multi-angiokinase inhibitor has achieved great

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a6380c470a4be26e380966eab21f579
http://europepmc.org/articles/PMC7488503

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Bioengineered miR-328-3p modulates GLUT1-mediated glucose uptake and metabolism to exert synergistic antiproliferative effects with chemotherapeutics

Autor: Aiming Yu, Wanrong Yi, Zhenzhen Liu, Ai Xi Yu, Neelu Batra, Chao Zhang, Mei Juan Tu

Publikováno v: Acta Pharmaceutica Sinica B, Vol 10, Iss 1, Pp 159-170 (2020)
Acta pharmaceutica Sinica. B, vol 10, iss 1
Acta Pharmaceutica Sinica. B

MicroRNAs (miRNAs or miRs) are small noncoding RNAs derived from genome to control target gene expression. Recently we have developed a novel platform permitting high-yield production of bioengineered miRNA agents (BERA). This study is to produce and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4966bffb1e8f2696d9cea62318cff94d
http://www.sciencedirect.com/science/article/pii/S2211383519309086

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