Time-Dependent Protective and Pro-Resolving Effects of FPR2 Agonists on Lipopolysaccharide-Exposed Microglia Cells Involve Inhibition of NF-κB and MAPKs Pathways

Autor: Kinga Tylek, Ewa Trojan, Monika Leśkiewicz, Magdalena Regulska, Natalia Bryniarska, Katarzyna Curzytek, Enza Lacivita, Marcello Leopoldo, Agnieszka Basta-Kaim

Publikováno v: Cells, Vol 10, Iss 9, p 2373 (2021)

Prolonged or excessive microglial activation may lead to disturbances in the resolution of inflammation (RoI). The importance of specialized pro-resolving lipid mediators (SPMs) in RoI has been highlighted. Among them, lipoxins (LXA4) and aspirin-tri

Externí odkaz: https://doaj.org/article/26d2884d296f4d0fbb1fe7a110ee7d32

Time-Dependent Protective and Pro-Resolving Effects of FPR2 Agonists on Lipopolysaccharide-Exposed Microglia Cells Involve Inhibition of NF-κB and MAPKs Pathways

Autor: Monika Leśkiewicz, Kinga Tylek, Magdalena Regulska, Agnieszka Basta-Kaim, Natalia Bryniarska, Katarzyna Curzytek, Enza Lacivita, Marcello Leopoldo, Ewa Trojan

Publikováno v: Cells
Volume 10
Issue 9
Cells, Vol 10, Iss 2373, p 2373 (2021)

Prolonged or excessive microglial activation may lead to disturbances in the resolution of inflammation (RoI). The importance of specialized pro-resolving lipid mediators (SPMs) in RoI has been highlighted. Among them, lipoxins (LXA4) and aspirin-tri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4359b5eb2a5efb7f7037c2728f133388
https://pubmed.ncbi.nlm.nih.gov/34572022

The N-Formyl Peptide Receptor 2 (FPR2) Agonist MR-39 Exhibits Anti-Inflammatory Activity in LPS-Stimulated Organotypic Hippocampal Cultures

Autor: Marcello Leopoldo, Lars-Ove Brandenburg, Monika Leśkiewicz, Enza Lacivita, Agnieszka Basta-Kaim, Ewa Trojan, Kinga Tylek, Władysław Lasoń

Publikováno v: Cells : open access journal 10(6), 1524 (2021). doi:10.3390/cells10061524 special issue: "Special Issue "Studies around Neuroinflammation-Series 2" / Special Issue Editor: Dr. Lars Ove Brandenburg, Guest Editor"
Cells
Cells, Vol 10, Iss 1524, p 1524 (2021)
Volume 10
Issue 6

Accumulating evidence indicates a pivotal role for chronic inflammatory processes in the pathogenesis of neurodegenerative and psychiatric disorders. G protein-coupled formyl peptide receptor 2 (FPR2) mediates pro-inflammatory or anti-/pro-resolving

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f28c341486761434f299a7ec610d09

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