Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+CD38- progenitor cells

Autor: LW Terstappen, S Huang, M Safford, PM Lansdorp, MR Loken

Publikováno v: Blood. 77:1218-1227

Multiparameter flow cytometry was applied on normal human bone marrow (BM) cells to study the lineage commitment of progenitor cells ie, CD34+ cells. Lineage commitment of the CD34+ cells into the erythroid lineage was assessed by the coexpression of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::758a6406db2b1858955eb977bdc08b42
https://doi.org/10.1182/blood.v77.6.1218.bloodjournal7761218

Assessment of proliferation during maturation of the B lymphoid lineage in normal human bone marrow

Autor: Z Hollander, VO Shah, CI Civin, MR Loken

Publikováno v: Blood. 71:528-531

Different stages of B lymphoid maturation were identified in normal bone marrow using multiple cell surface markers. The proliferation status of each of these maturational stages was determined by simultaneous quantitative DNA analysis on a flow cyto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66b8ef8bfef82f59ec0bf754621ef71e
https://doi.org/10.1182/blood.v71.2.528.bloodjournal712528

Flow cytometric analysis of human bone marrow: I. Normal erythroid development

Autor: MR Loken, VO Shah, KL Dattilio, CI Civin

Publikováno v: Blood. 69(1)

Flow cytometry was used to identify maturational differences of erythroid lineage cells in normal human bone marrow by combining physical characteristics, the expression of multiple cell surface antigens, and nucleic acid content. Normal low-density

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f446c2d7870e05035c7928098d76e6f9
https://pubmed.ncbi.nlm.nih.gov/2947644

Monitoring clonal burden as an alternative to blast count for myelodysplastic neoplasm treatment response.

Autor: Jacoby MA; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Duncavage ED; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA., Khanna A; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA., Chang GS; McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO, USA., Nonavinkere Srivatsan S; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Miller CA; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Gao F; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, MO, USA., Robinson J; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA., Shao J; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Fulton RS; McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO, USA., Fronick CC; McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO, USA., O'Laughlin M; McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO, USA., Heath SE; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Brendel K; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Chavez M; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., DiPersio JF; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Abboud CN; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Stockerl-Goldstein K; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Westervelt P; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.; MaineHealth Cancer Center, Scarborough, ME, USA., Cashen A; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Pusic I; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Oh ST; Division of Hematology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Welch JS; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.; A2 Biotherapeutics Inc., Agoura Hills, CA, USA., Wells DA; Hematologics Inc., Seattle, WA, USA., Loken MR; Hematologics Inc., Seattle, WA, USA., Uy GL; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA. guy@wustl.edu., Walter MJ; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA. mjwalter@wustl.edu.

Publikováno v: Leukemia [Leukemia] 2024 Oct 04. Date of Electronic Publication: 2024 Oct 04.

Cytokine-mediated CAR T therapy resistance in AML.

Autor: Bhagwat AS; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Torres L; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Immunology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Shestova O; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Shestov M; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Mellors PW; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Fisher HR; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Farooki SN; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Frost BF; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Loken MR; Hematologics Inc., Seattle, WA, USA., Gaymon AL; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Frazee D; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Rogal W; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Frey N; Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Cell Therapy and Transplant, University of Pennsylvania, Philadelphia, PA, USA., Hexner EO; Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Cell Therapy and Transplant, University of Pennsylvania, Philadelphia, PA, USA., Luger SM; Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Loren AW; Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Cell Therapy and Transplant, University of Pennsylvania, Philadelphia, PA, USA., Martin ME; Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Cell Therapy and Transplant, University of Pennsylvania, Philadelphia, PA, USA., McCurdy SR; Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Cell Therapy and Transplant, University of Pennsylvania, Philadelphia, PA, USA., Perl AE; Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Cell Therapy and Transplant, University of Pennsylvania, Philadelphia, PA, USA., Stadtmauer EA; Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Cell Therapy and Transplant, University of Pennsylvania, Philadelphia, PA, USA., Brogdon JL; Novartis Biomedical Research, Cambridge, MA, USA., Fraietta JA; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Hwang WT; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA., Siegel DL; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Plesa G; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Aplenc R; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Porter DL; Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Cell Therapy and Transplant, University of Pennsylvania, Philadelphia, PA, USA., June CH; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Gill SI; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. saar.gill2@pennmedicine.upenn.edu.; Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA. saar.gill2@pennmedicine.upenn.edu.; Center for Cell Therapy and Transplant, University of Pennsylvania, Philadelphia, PA, USA. saar.gill2@pennmedicine.upenn.edu.

Publikováno v: Nature medicine [Nat Med] 2024 Sep 27. Date of Electronic Publication: 2024 Sep 27.