Zobrazeno 1 - 10
of 50
pro vyhledávání: '"MPTP, mitochondrial permeability transition pore"'
Autor:
David A. Frank, Isidora Tošić
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1167-1178 (2021)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1167-1178 (2021)
The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is activated constitutively in a wide array of human cancers. It is an appealing molecular target for novel therapy as it directly regulates expression of g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95fc1e221705a2edcb47149735290583
http://europepmc.org/articles/PMC8569436
http://europepmc.org/articles/PMC8569436
Autor:
N.V. Vorobjeva
Publikováno v:
Moscow University Biological Sciences Bulletin
— Neutrophils are the “first line” of defense against pathogens in the locus of inflammation, where they use effector functions such as phagocytosis, degranulation, and formation of reactive oxygen species (ROS). In 2004, Artuto Zychlinsky char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01f41f8c5f92ac886ffa0590ea714b0
http://europepmc.org/articles/PMC7869772
http://europepmc.org/articles/PMC7869772
Autor:
Johannes Seeger, Marie Mewes, Sophie Sigusch, Aida Salameh, Ingo Dähnert, Marcel Vollroth, Stefan Dhein, Philipp Kiefer
Publikováno v:
Saudi Journal of Biological Sciences, Vol 27, Iss 1, Pp 18-29 (2020)
Saudi Journal of Biological Sciences
Saudi Journal of Biological Sciences
Severe inborn cardiac malformations are typically corrected in cardioplegia, with a cardio-pulmonary bypass (CPB) taking over body circulation. During the operation the arrested hearts are subjected to a global ischemia/reperfusion injury. Although t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5365bb8c01902b28b5ec20940c25b5
https://doi.org/10.1016/j.sjbs.2019.04.003
https://doi.org/10.1016/j.sjbs.2019.04.003
Autor:
Hani N. Sabbah
Publikováno v:
JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 5, Iss 1, Pp 88-106 (2020)
JACC: Basic to Translational Science, Vol 5, Iss 1, Pp 88-106 (2020)
Visual Abstract
Highlights • Cardiac energy deprivation due to mitochondrial dysfunction is characteristic of heart failure. • Mitochondrial dysfunction contributes to worsening of the heart failure state. • Pharmacologic targeting of mito
Highlights • Cardiac energy deprivation due to mitochondrial dysfunction is characteristic of heart failure. • Mitochondrial dysfunction contributes to worsening of the heart failure state. • Pharmacologic targeting of mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7bf223c5fc74d0943fdde83a16b2755
http://europepmc.org/articles/PMC7000886
http://europepmc.org/articles/PMC7000886
Autor:
Hong Soon Kang, Anton M. Jetten, Kevin Gerrish, Amir Aghajanian, Ju Youn Beak, Brian C. Jensen, Seok Jae Hong, Wei Huang, Rishi Deshmukh, Nishi Kadakia
Publikováno v:
The Journal of Biological Chemistry
Preserving optimal mitochondrial function is critical in the heart, which is the most ATP-avid organ in the body. Recently, we showed that global deficiency of the nuclear receptor RORα in the "staggerer" mouse exacerbates angiotensin II-induced car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47cc243bde3123b1ebf3e9dc15c170f2
http://europepmc.org/articles/PMC8626585
http://europepmc.org/articles/PMC8626585
Autor:
Shaoping Guan, Xinping Liu, Richard W. Gross, Harold F. Sims, Beverly Gibson Dilthey, Sung Ho Moon
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100052-(2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100052-(2021)
High-fat (HF) diet–induced obesity precipitates multiple metabolic disorders including insulin resistance, glucose intolerance, oxidative stress, and inflammation, resulting in the initiation of cell death programs. Previously, we demonstrated muri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac707a6479481fac40eba79f66d3ab5b
http://europepmc.org/articles/PMC8010217
http://europepmc.org/articles/PMC8010217
Autor:
Liyuan Cao, Wei Mu
Publikováno v:
Pharmacological Research
Graphical abstract
Necrostatin-1 (Nec-1) is a RIP1-targeted inhibitor of necroptosis, a form of programmed cell death discovered and investigated in recent years. There are already many studies demonstrating the essential role of necroptosis in
Necrostatin-1 (Nec-1) is a RIP1-targeted inhibitor of necroptosis, a form of programmed cell death discovered and investigated in recent years. There are already many studies demonstrating the essential role of necroptosis in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b673f8b687ffb866bd8f37e46b2c624
Autor:
Rodrigo A. Quintanilla, María José Pérez, Daniela P. Ponce, Alejandra Aranguiz, Maria I. Behrens
Publikováno v:
Redox Biology, Vol 19, Iss, Pp 290-300 (2018)
Redox Biology
Redox Biology
In the last few decades, many reports have suggested that mitochondrial function impairment is a hallmark of Alzheimer's disease (AD). Although AD is a neurodegenerative disorder, mitochondrial damage is also present in patients’ peripheral tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::833f7142687d8a3e757b00044c1e2264
https://doi.org/10.1016/j.redox.2018.09.001
https://doi.org/10.1016/j.redox.2018.09.001
Publikováno v:
Redox Biology, Vol 18, Iss, Pp 279-294 (2018)
Redox Biology
Redox Biology
Tau is a key protein for microtubule stability; however, post-translationally modified tau contributes to neurodegenerative diseases by forming tau aggregates in the neurons. Previous reports from our group and others have shown that pathological for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2f553ad0342b33fd6d09fcde65ae42
https://doi.org/10.1016/j.redox.2018.07.010
https://doi.org/10.1016/j.redox.2018.07.010
Autor:
Chengyuan Tang, Xiaofen Xiong, Xiaoxuan Xu, Lin Sun, Shuguang Yuan, Yachun Han, Xianghui Chen, Shikun Yang, Yashpal S. Kanwar, Fuyou Liu, Xuejing Zhu, Ming Yang, Li Xiao, Peng Gao
Publikováno v:
Redox Biology
Redox Biology, Vol 16, Iss, Pp 32-46 (2018)
Redox Biology, Vol 16, Iss, Pp 32-46 (2018)
NLRP3/IL-1β activation via thioredoxin (TRX)/thioredoxin-interacting protein (TXNIP) following mitochondria ROS (mtROS) overproduction plays a key role in inflammation. However, the involvement of this process in tubular damage in the kidneys of pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb01cc8d366dba9d9e8efe1eccaf3915
http://europepmc.org/articles/PMC5842313
http://europepmc.org/articles/PMC5842313