Glomerular Immune Deposition in MPO-ANCA Associated Glomerulonephritis Is Associated With Poor Renal Survival

Autor: Wei Lin, Chanjuan Shen, Yong Zhong, Joshua D. Ooi, Peter Eggenhuizen, Ya-Ou Zhou, Hui Luo, Jing Huang, Jin-Biao Chen, Ting Wu, Ting Meng, Zhou Xiao, Xiang Ao, Weisheng Peng, Rong Tang, Hongling Yin, Xiangcheng Xiao, Qiaoling Zhou, Ping Xiao

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

BackgroundRapidly progressive glomerulonephritis caused by antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is typically characterized as pauci-immune glomerulonephritis. However, immune complex (IC) deposition in the glomerulus

Externí odkaz: https://doaj.org/article/942a4e42f5454e2b9fa6675e62c3858c

2’-Fucosyllactose Ameliorates Chemotherapy-Induced Intestinal Mucositis by Protecting Intestinal Epithelial Cells Against Apoptosis

Autor: Steven D. Townsend, Yaohua Yang, Jirong Long, Fang Yan, M. Kay Washington, Gang Zhao, Jessica Williams

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 441-457 (2022)

Background & Aims Intestinal mucositis, a severe complication of antineoplastic therapeutics, is characterized by mucosal injury and inflammation in the small intestine. Therapies for the prevention and treatment of this disease are needed. We invest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cecb7b66e0a7213c576cf778eedd4f80
http://europepmc.org/articles/PMC8688723

Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation

Autor: Jian Liu, Qi Lv, Yinan Zhang, Yao Xing, Dong Dong, Yue Liu, Lihong Hu, Hongzhi Qiao

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2880-2899 (2021)

Aberrant activation of NLRP3 inflammasome in colonic macrophages strongly associates with the occurrence and progression of ulcerative colitis. Although targeting NLRP3 inflammasome has been considered to be a potential therapy, the underlying mechan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b197d7e1bd61447a9d7a45da0a56387
https://doi.org/10.1016/j.apsb.2021.03.011

Malignancy-associated Sweet syndrome presenting with simultaneous histopathologic and morphologic variants

Autor: Kiran Motaparthi, Nathan Burke, Nicole R. Bender, Sami K Saikaly

Publikováno v: JAAD Case Reports, Vol 14, Iss, Pp 104-107 (2021)
JAAD Case Reports

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e1f6478d119508148be6d15576b8b3
https://doi.org/10.1016/j.jdcr.2021.06.007

Defining the role of CFTR channel blocker and ClC-2 activator in DNBS induced gastrointestinal inflammation

Autor: Vijay R. Chidrawar, Bader Alsuwayt

Publikováno v: Saudi Pharmaceutical Journal : SPJ

In the present study, we have investigated and/or compared the role of glibenclamide, G as cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor, and lubiprostone, L as chloride channel-2 (ClC-2) activator in the 2,4-dinitrobenzene sul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae14bfe965e654468af30a05663d9b28
https://doi.org/10.1016/j.jsps.2021.02.005