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Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization

Autor: Motti, M. L., Califano, D., Troncone, G., Marco, C., Migliaccio, I., Palmieri, E., Pezzullo, L., Palombini, L., Alfredo Fusco, Viglietto, G.

Publikováno v: 166 (2005): 737–749.
info:cnr-pdr/source/autori:Motti ML, Califano D, Troncone G, De Marco C, Migliaccio I, Palmieri E, Pezzullo L, Palombini L, Fusco A, Viglietto G./titolo:Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K%2FAKT pathway: regulation of p27kip1 expression and localization./doi:/rivista:/anno:2005/pagina_da:737/pagina_a:749/intervallo_pagine:737–749/volume:166
Scopus-Elsevier

Functional inactivation of the tumor suppressor p27(kip1) in human cancer occurs either through loss of expression or through phosphorylation-dependent cytoplasmic sequestration. Here we demonstrate that dysregulation of the PI3K/AKT pathway is impor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::654f5ffe3034a91ccdce5685ae2f30d2
https://publications.cnr.it/doc/21268

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Retinoic acid induces neuronal differentiation of embryonal carcinoma cells by reducing proteasome-dependent proteolysis of the cyclin-dependent inhibitor p27

Autor: Baldassarre, G., Boccia, A., Bruni, P., Sandomenico, C., Maria Vittoria BARONE, Pepe, S., Angrisano, T., Belletti, B., Motti, M. L., Fusco, A., Viglietto, G.

Publikováno v: Scopus-Elsevier
CIÊNCIAVITAE
Europe PubMed Central

Retinoic acid (RA) treatment of embryonal carcinoma cell line NTERA-2 clone D1 (NT2/D1) induces growth arrest and terminal differentiation along the neuronal pathway. In the present study, we provide a functional link between RA and p27 function in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1e642d4f1f4f9f5be034ad45d119ccc3
http://hdl.handle.net/11588/491931

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Loss of the tumor suppressor gene PTEN marks the transition from intratubular germ cell neoplasias (ITGCN) to invasive germ cell tumors

Autor: Alfredo Fusco, Wanda D'Amico, Barbara Tavernise, Luigi Insabato, Filippo Schepis, Guido Pettinato, Dolores Di Vizio, Maria Letizia Motti, Paolo Chieffi, Fernanda Fabiani, Letizia Cito, Salvatore Venuta, Angelo Boccia, Giuseppe Viglietto

Publikováno v: Oncogene (Basingstoke) 24 (2005): 1882–1894.
info:cnr-pdr/source/autori:Di Vizio D, Cito L, Boccia A, Chieffi P, Insabato L, Pettinato G, Motti ML, Schepis F, D'Amico W, Fabiani F, Tavernise B, Venuta S, Fusco A, Viglietto G./titolo:Loss of the tumor suppressor gene PTEN marks the transition from intratubular germ cell neoplasias (ITGCN) to invasive germ cell tumors./doi:/rivista:Oncogene (Basingstoke)/anno:2005/pagina_da:1882/pagina_a:1894/intervallo_pagine:1882–1894/volume:24

PTEN/MMAC1/TEP1: (hereafter PTEN) is a tumor suppressor gene (located at 10q23) that is frequently mutated or deleted in sporadic human tumors. PTEN encodes a multifunctional phosphatase, which negatively regulates cell growth, migration and survival

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c8a124b575054caa65177a5d6763562
https://pubmed.ncbi.nlm.nih.gov/15674339

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Regulation of p27Kip1 protein levels contributes to mitogenic effects of the RET/PTC kinase in thyroid carcinoma cells

Autor: Rosa Marina Melillo, Donata Vitagliano, Maria Letizia Motti, Anderson J. Ryan, Massimo Santoro, Giuseppe Viglietto, Alfredo Fusco, Francesca Carlomagno, Jerome M. Hershman, Marina N. Nikiforova, Yuri E. Nikiforov

We show that treatment of a panel of thyroid carcinoma cell lines naturally harboring the RET/PTC1 oncogene, with the RET kinase inhibitors PP1 and ZD6474, results in reversible G1 arrest. This is accompanied by interruption of Shc and mitogen-activa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe22471d703e342e7a17f18a77e15f8
http://hdl.handle.net/11588/201323

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Akt-dependent T198 phosphorylation of cyclin-dependent kinase inhibitor p27kip1in breast cancer

Autor: Giuseppe Viglietto, Daniela Califano, Maria Letizia Motti, Alfredo Fusco, Carmela De Marco

Publikováno v: Scopus-Elsevier

The localization of the cyclin-dependent kinase inhibitor p27(kip1) is dependent on the phosphorylation of one of three key amino acid residues: S10, T157 and T198. However, it was unclear whether endogenous p27(kip1) is phosphorylated at T198 in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6617f6079c0fbde6520ffe9333267c42
http://www.scopus.com/inward/record.url?eid=2-s2.0-10044244277&partnerID=MN8TOARS

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Akademický článek

Characterization of 2 novel and 2 recurring BRCA1 germline mutations in breast and/or ovarian carcinoma patients from the area of Naples.

Autor: Curci A; Istituto Nazionale Tumori, Fondazione Pascale, Naples, Italy., Capasso I, Romano A, Bruni P, Motti ML, Pignata S, D'Aiuto G, Casamassimi A, D'Urso M, Fusco A, Viglietto G

Publikováno v: International journal of oncology [Int J Oncol] 2002 May; Vol. 20 (5), pp. 963-70.

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