MINCLE and TLR9 agonists synergize to induce Th1/Th17 vaccine memory and mucosal recall in mice and non-human primates.

Autor: Woodworth JS; Department of Infectious Disease Immunology, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen, Denmark. jow@ssi.dk., Contreras V; Université Paris-Saclay, Inserm, CEA, Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes (IMVA-HB/IDMIT/UMR1184), 92265, Fontenay-aux-Roses & Kremlin Bicêtre, France., Christensen D; Department of Infectious Disease Immunology, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen, Denmark., Naninck T; Université Paris-Saclay, Inserm, CEA, Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes (IMVA-HB/IDMIT/UMR1184), 92265, Fontenay-aux-Roses & Kremlin Bicêtre, France., Kahlaoui N; Université Paris-Saclay, Inserm, CEA, Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes (IMVA-HB/IDMIT/UMR1184), 92265, Fontenay-aux-Roses & Kremlin Bicêtre, France., Gallouët AS; Université Paris-Saclay, Inserm, CEA, Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes (IMVA-HB/IDMIT/UMR1184), 92265, Fontenay-aux-Roses & Kremlin Bicêtre, France., Langlois S; Université Paris-Saclay, Inserm, CEA, Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes (IMVA-HB/IDMIT/UMR1184), 92265, Fontenay-aux-Roses & Kremlin Bicêtre, France., Burban E; Université Paris-Saclay, Inserm, CEA, Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes (IMVA-HB/IDMIT/UMR1184), 92265, Fontenay-aux-Roses & Kremlin Bicêtre, France., Joly C; Université Paris-Saclay, Inserm, CEA, Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes (IMVA-HB/IDMIT/UMR1184), 92265, Fontenay-aux-Roses & Kremlin Bicêtre, France., Gros W; Université Paris-Saclay, Inserm, CEA, Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes (IMVA-HB/IDMIT/UMR1184), 92265, Fontenay-aux-Roses & Kremlin Bicêtre, France., Dereuddre-Bosquet N; Université Paris-Saclay, Inserm, CEA, Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes (IMVA-HB/IDMIT/UMR1184), 92265, Fontenay-aux-Roses & Kremlin Bicêtre, France., Morin J; Université Paris-Saclay, Inserm, CEA, Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes (IMVA-HB/IDMIT/UMR1184), 92265, Fontenay-aux-Roses & Kremlin Bicêtre, France., Liu Olsen M; Department of Infectious Disease Immunology, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen, Denmark., Rosenkrands I; Department of Infectious Disease Immunology, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen, Denmark., Stein AK; Department of Vaccine Development, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen, Denmark., Krøyer Wood G; Department of Vaccine Development, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen, Denmark., Follmann F; Department of Infectious Disease Immunology, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen, Denmark., Lindenstrøm T; Department of Infectious Disease Immunology, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen, Denmark., Hu T; Department of Infectious Disease Immunology, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen, Denmark., Le Grand R; Université Paris-Saclay, Inserm, CEA, Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes (IMVA-HB/IDMIT/UMR1184), 92265, Fontenay-aux-Roses & Kremlin Bicêtre, France., Pedersen GK; Department of Infectious Disease Immunology, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen, Denmark., Mortensen R; Department of Infectious Disease Immunology, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen, Denmark. rjm@ssi.dk.

Publikováno v: Nature communications [Nat Commun] 2024 Oct 17; Vol. 15 (1), pp. 8959. Date of Electronic Publication: 2024 Oct 17.

Itaconate transporter SLC13A3 impairs tumor immunity via endowing ferroptosis resistance.

Autor: Lin H; Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA., Tison K; Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA; Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA., Du Y; Department of Computational Medicine & Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA., Kirchhoff P; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA., Kim C; Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA; Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, South Korea., Wang W; Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA., Yang H; Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA; Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, South Korea., Pitter M; Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA., Yu J; Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA., Liao P; Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA., Zhou J; Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA., Vatan L; Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA., Grove S; Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA., Wei S; Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA., Vigil T; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Shah YM; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Mortensen R; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA., Kryczek I; Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA., Garmire L; Department of Computational Medicine & Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA., Sivaccumar JP; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA., Ramesh AK; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA., Zhang N; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA., An Z; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA., Wang S; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Medicinal Chemistry, University of Michigan Medical School, Ann Arbor, MI, USA., Zou W; Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA; Graduate Program in Cancer Biology, University of Michigan, Ann Arbor, MI, USA. Electronic address: wzou@umich.edu.

Publikováno v: Cancer cell [Cancer Cell] 2024 Dec 09; Vol. 42 (12), pp. 2032-2044.e6. Date of Electronic Publication: 2024 Nov 07.

Measurement of the neutron $\beta$-asymmetry parameter $A_0$ with ultracold neutrons

Autor: UCNA Collaboration, Plaster, B., Rios, R., Back, H. O., Bowles, T. J., Broussard, L. J., Carr, R., Clayton, S., Currie, S., Filippone, B. W., Garcia, A., Geltenbort, P., Hickerson, K. P., Hoagland, J., Hogan, G. E., Hona, B., Holley, A. T., Ito, T. M., Liu, C. -Y., Liu, J., Makela, M., Mammei, R. R., Martin, J. W., Melconian, D., Mendenhall, M. P., Morris, C. L., Mortensen, R., Pattie, Jr., R. W., Galvan, A. Perez, Pitt, M. L., Ramsey, J. C., Russell, R., Saunders, A., Schmid, R., Seestrom, S. J., Sjue, S., Sondheim, W. E., Tatar, E., Tipton, B., Vogelaar, R. B., VornDick, B., Wrede, C., Xu, Y. P., Yan, H., Young, A. R., Yuan, J.

We present a detailed report of a measurement of the neutron $\beta$-asymmetry parameter $A_0$, the parity-violating angular correlation between the neutron spin and the decay electron momentum, performed with polarized ultracold neutrons (UCN). UCN

Externí odkaz: http://arxiv.org/abs/1207.5887

Measurements of ultracold neutron lifetimes in solid deuterium

Autor: Morris, C. L., Anaya, J. M., Bowles, T. J., Filippone, B. W., Geltenbort, P., Hill, R. E., Hino, M., Hoedl, S., Hogan, G. E., Ito, T. M., Kawai, T., Kirch, K., Lamoreaux, S. K., Liu, C. -Y., Makela, M., Marek, L. J., Martin, J. W., Mortensen, R. N., Pichlmaier, A., Saunders, A., Seestrom, S. J., Smith, D., Teasdale, W., Tipton, B., Utsuro, M., Young, A. R., Yuan, J.

Publikováno v: Phys.Rev.Lett.89:272501,2002

We present the first measurements of the survival time of ultracold neutrons (UCNs) in solid deuterium SD2. This critical parameter provides a fundamental limitation to the effectiveness of superthermal UCN sources that utilize solid ortho-deuterium

Externí odkaz: http://arxiv.org/abs/nucl-ex/0109020

Author Correction: Cyclooxygenase inhibitors impair CD4 T cell immunity and exacerbate Mycobacterium tuberculosis infection in aerosol-challenged mice.

Autor: Mortensen R; Department of Infectious Disease Immunology, Statens Serum Institut, 2300, Copenhagen S, Denmark. rjm@ssi.dk., Clemmensen HS; Department of Infectious Disease Immunology, Statens Serum Institut, 2300, Copenhagen S, Denmark., Woodworth JS; Department of Infectious Disease Immunology, Statens Serum Institut, 2300, Copenhagen S, Denmark., Therkelsen ML; Department of Infectious Disease Immunology, Statens Serum Institut, 2300, Copenhagen S, Denmark., Mustafa T; Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen & Department of Thoracic Medicine, Haukeland University Hospital, 5021, Bergen, Norway., Tonby K; Department of Infectious Diseases, Oslo University Hospital, 0424, Oslo, Norway., Jenum S; Department of Infectious Diseases, Oslo University Hospital, 0424, Oslo, Norway., Agger EM; Department of Infectious Disease Immunology, Statens Serum Institut, 2300, Copenhagen S, Denmark., Dyrhol-Riise AM; Department of Infectious Diseases, Oslo University Hospital, 0424, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, 0424, Oslo, Norway.; Department of Clinical Science, University of Bergen, 5020, Bergen, Norway., Andersen P; Department of Infectious Disease Immunology, Statens Serum Institut, 2300, Copenhagen S, Denmark.; Department of Immunology and Microbiology, University of Copenhagen, 2200, Copenhagen N, Denmark.

Publikováno v: Communications biology [Commun Biol] 2024 May 29; Vol. 7 (1), pp. 662. Date of Electronic Publication: 2024 May 29.