Výsledky vyhledávání - "MORSELT, HWM"

Immunoliposomes directed against colon adenocarcinoma cells: Delivery of 5-fluorodeoxyuridine to colon cancer cells and targeting to liver metastases

Autor: Kamps, JAAM, Morselt, HWM, Scherphof, GL, Koning, GA, Svenson, S

Publikováno v: POLYMERIC DRUG DELIVERY I: PARTICULATE DRUG CARRIERS, 84-94
STARTPAGE=84;ENDPAGE=94;TITLE=POLYMERIC DRUG DELIVERY I: PARTICULATE DRUG CARRIERS

Tumor cell-specific immunoliposomes have been applied to deliver a dipalmitoyl derivative of 5-fluorodeoxyuridine (FUdR-dP) to CC531 adenocarcinoma cells. Immunoliposomes containing FUdR-dP caused stronger inhibition of CC531 in vitro cell growth tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::54fb14b92d47d0c057501b288f7aa2f6
https://research.rug.nl/en/publications/60dbd180-661e-492f-9cdd-ad8bcc11e3f5

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Interaction of differently designed immunoliposomes with colon cancer cells and Kupffer cells. An in vitro comparison

Autor: Koning, GA, Morselt, HWM, Gorter, A, Allen, TM, Zalipsky, S, Scherphof, GL, Kamps, JAAM

Publikováno v: Pharmaceutical Research, 20(8), 1249-1257. SPRINGER/PLENUM PUBLISHERS

Purpose. Evaluate the effectiveness of distal-end coupling of a tumor-specific antibody to liposomal polyethylene glycol (PEG) chains to improve target binding and reduce interference by macrophage uptake. Methods. Monoclonal antibody CC52, specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::1f88bd7ade8e90a1cf182fadb7b849fc
https://research.rug.nl/en/publications/0a26b7e2-d845-4da4-a1f2-1019ca4e5a49

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Pharmacokinetics of differently designed immunoliposome formulations in rats with or without hepatic colon cancer metastases

Autor: Koning, GA, Morselt, HWM, Gorter, A, Allen, TM, Zalipsky, S, Kamps, JAAM, Scherphof, GL

Publikováno v: Pharmaceutical Research, 18(9), 1291-1298. SPRINGER/PLENUM PUBLISHERS

Purpose. Compare pharmacokinetics of tumor-directed immunoliposomes in healthy and tumor-bearing rats (hepatic colon. cancer metastases). Methods. A tumor cell-specific monoclonal antibody was attached to polyethyleneglycol-stabilized liposomes, eith

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::862a412d0b50582b041926dc08eb2a6c
https://research.rug.nl/en/publications/6351b190-db2f-4080-b7a6-51ede2f04ff2

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Uptake and intracellular processing of PEG-liposomes and PEG-immunoliposomes by Kupffer cells in vitro

Autor: Koning, GA, Morselt, HWM, Kamps, JAAM, Scherphof, GL

Publikováno v: Journal of Liposome Research, 11(2-3), 195-209

Specific targeting of drugs to for instance tumors or sites of inflammation may be achieved by means of immunoliposomes carrying site-specific antibodies on their surface. The presence of these antibodies may adversely affect the circulation kinetics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::dd284c93a49ebcfa95cde400a8721971
https://research.rug.nl/en/publications/681122e7-e8ba-418e-94e4-8475ca03e51b

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Uptake of long-circulating immunoliposomes, directed against colon adenocarcinoma cells, by liver metastases of colon cancer

Autor: Kamps, JAAM, Koning, GA, Morselt, HWM, Wilkens, M, Gorter, A, Donga, J, Scherphof, GL

Publikováno v: Journal of Drug Targeting, 8(4), 235-+. TAYLOR & FRANCIS LTD

Radiolabeled ([H-3]cholesteryloleyl ether) immunoliposomes directed against rat colon adenocarcinoma CC531 cells were prepared by random coupling of a tumor cell-specific antibody, CC52, via a thio-ether bond. In vitro binding experiments demonstrate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::82217ae1eadbab821f0740e3d90b9db8
https://research.rug.nl/en/publications/3a3f4927-bfa9-4ca6-aca8-e6db828525c6

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Selective transfer of a lipophilic prodrug of 5-fluorodeoxyuridine from immunoliposomes to colon cancer cells

Autor: Koning, GA, Morselt, HWM, Donga, J, Gorter, A, Allen, TM, Zalipsky, S, Kamps, JAAM, Scherphof, GL

Publikováno v: Biochimica et Biophysica Acta-Biomembranes, 1420(1-2), 153-167. Elsevier

A monoclonal antibody against the rat colon carcinoma CC531 was covalently coupled to liposomes containing a dipalmitoylated derivative of the anticancer drug FUdR as a prodrug in their bilayers. We investigated the in vitro interaction of these lipo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::657f34f4467bd158d1318d72be01417c
https://research.rug.nl/en/publications/4841bdc6-0442-49b8-b6ba-dcc56dd4910b

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Uptake of liposomes containing phosphatidylserine by liver cells in vivo and by sinusoidal liver cells in primary culture: In vivo-in vitro differences

Autor: Kamps, JAAM, Morselt, HWM, Scherphof, GL

Publikováno v: Biochemical and Biophysical Research Communications, 256(1), 57-62. ACADEMIC PRESS INC ELSEVIER SCIENCE

The interaction with liver cells of liposomes containing different mol fractions of phosphatidylserine was investigated in vivo and in vitro. Increasing the amount of liposomal phosphatidylserine from 10 to 30 mol% leads to a faster blood disappearan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::a32da11446a7e51c7267851a18f6eb3a
https://research.rug.nl/en/publications/c963bcd9-e73d-4b62-ae9f-3670591089f8

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Targeting of liposomes to sinusoidal liver cells: Massive uptake by liver endothelial cells via a scavenger receptor mediated process

Autor: Kamps, JAAM, Morselt, HWM, Swart, PJ, Meijer, DKF, Scherphof, GL, Wisse, E, Knook, DL, Balabaud, C

Publikováno v: CELLS OF THE HEPATIC SINUSOID, VOL 6, 387-388
STARTPAGE=387;ENDPAGE=388;TITLE=CELLS OF THE HEPATIC SINUSOID, VOL 6

Human serum albumin (HSA) derivatized with cis-aconitic anhydride (Aco-HSA) was covalently coupled to liposomes (Aco-HSA-Lip). Aco-HSA-Lip were cleared from the blood and taken up by the liver within 30 minutes after injection into a rat. In the live

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::1dc1ac1f98fbaab85cdc5fe054c7dd05
https://research.rug.nl/en/publications/529f0d62-fce4-4655-9f41-3550db166c51

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HETEROGENEITY IN SECRETORY RESPONSES OF RAT-LIVER MACROPHAGES OF DIFFERENT SIZE

Autor: HOEDEMAKERS, RMJ, MORSELT, HWM, SCHERPHOF, GL, DAEMEN, T

Publikováno v: Liver, 15(6), 313-319

Four subpopulations of hepatic macrophages, differing in size, were isolated from rat liver. The secretion of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), prostaglandin E (PGE) and interleukin-1 (IL-1) by freshly isolated as well as cu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::8ae262cfaddfbcd34338902701960d84
https://research.rug.nl/en/publications/1a1b7f10-7eb2-49c1-97e7-3c78e46d124c

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