Inhibition of Drp1 protects against senecionine-induced mitochondria-mediated apoptosis in primary hepatocytes and in mice

Autor: Li Yang, Aizhen Xiong, Wen-Xing Ding, Hua Wang, Hong-Min Ni, Xiao Yang, Zhengtao Wang, Hiromi Sesaki

Publikováno v: Redox Biology, Vol 12, Iss, Pp 264-273 (2017)
Redox Biology

Pyrrolizidine alkaloids (PAs) are a group of compounds found in various plants and some of them are widely consumed in the world as herbal medicines and food supplements. PAs are potent hepatotoxins that cause irreversible liver injury in animals and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e9e6428ec7632340316ab8afa41ea60
http://www.sciencedirect.com/science/article/pii/S2213231717300745

The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading

Autor: Carmen G. Vallejo, Nuria Matías, Laura Conde de la Rosa, Anna Baulies, Oihana Terrones, Neil Kaplowitz, Carmen García-Ruiz, Joaquín Abián, Hidekazu Tsukamoto, Albert Morales, Montserrat Carrascal, Laura Martínez, Keigo Machida, José C. Fernández-Checa, Dinesh Babu Uthaya Kumar, Joan Montero, Naroa Insausti, David Robles, Gorka Basañez

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Redox Biology, Vol 14, Iss, Pp 164-177 (2018)
Redox Biology

Cancer cells exhibit mitochondrial cholesterol (mt-cholesterol) accumulation, which contributes to cell death resistance by antagonizing mitochondrial outer membrane (MOM) permeabilization. Hepatocellular mt-cholesterol loading, however, promotes ste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcfd96360e402bd7c6f5fca29f6bb115
http://hdl.handle.net/10261/177199

Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions

Autor: Sanjeev Gupta, Karolina Pakos-Zebrucka, Peter Vandenabeele, Susan E. Logue, Mathieu J.M. Bertrand, Afshin Samali, Svetlana Saveljeva, Shane Deegan

Publikováno v: Autophagy

Endoplasmic reticulum (ER) stress-induced cell death is normally associated with activation of the mitochondrial apoptotic pathway, which is characterized by CYCS (cytochrome c, somatic) release, apoptosome formation, and caspase activation, resultin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f28c796284ac70d3b03988c7d028ed
https://doi.org/10.4161/15548627.2014.981790

A novel anti-proliferative role of HMGA2 in induction of apoptosis through caspase 2 in primary human fibroblast cells

Autor: Wenlong Ma, Na Zhang, Xi Shi, Yuehua Qiao, Baoqing Tian, Xiaoxue Li, Baiqu Huang, Yu Zhang, Jun Lu

Publikováno v: Bioscience Reports
Bioscience Reports, Vol 35, Iss 1, p e00169 (2015)

The HMGA2 (high-mobility group AT-hook) protein has previously been shown as an oncoprotein, whereas ectopic expression of HMGA2 is found to induce growth arrest in primary cells. The precise mechanisms underlying this phenomenon remain to be unravel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f2d3bedc3b516daa2daf41bd2b5179f
http://europepmc.org/articles/PMC4293904

Consensus guidelines for the detection of immunogenic cell death

Autor: Kepp, O., Senovilla, L., Vitale, I., Vacchelli, E., Adjemian, S., Agostinis, P., Apetoh, L., Aranda, F., Barnaba, V., Bloy, N., Bracci, L., Breckpot, K., Brough, D., Buqué, A., Castro, Mg, Cirone, M., Colombo, Mi, Cremer, I., Demaria, S., Dini, L., Eliopoulos, A., Faggioni, A., Formenti, Sc, Fu??íková, J., Gabriele, L., Gaipl, Us, Galon, J., Garg, A., Ghiringhelli, F., Giese, Na, Guo, Zs, Hemminki, A., Herrmann, M., Hodge, Jw, Holdenrieder, S., Honeychurch, J., Hm, Hu, Huang, X., Illidge, Tm, Kono, K., Korbelik, M., Krysko, Dv, Loi, S., Lowenstein, Pr, Lugli, E., Ma, Y., Madeo, F., Manfredi, Aa, Martins, I., Matzinger, P., Mavilio, D., Menger, L., Merendino, N., Michaud, M., Mignot, G., Mossman, Kl, Multhoff, G., Oehler, R., Palombo, F., Panaretakis, T., Pol, J., Proietti, E., Ricci, Je, Riganti, Chiara, Rovere Querini, P., Rubartelli, A., Sistigu, A., Smyth, Mj, Sonnemann, J., Spisek, R., Stagg, J., Sukkurwala, Aq, Tartour, E., Thorburn, A., Thorne, Sh, Vandenabeele, P., Velotti, F., Workenhe, Sr, Yang, H., Zong, Wx, Zitvogel, L., Kroemer, G., Galluzzi, L.

Publikováno v: OncoImmunology. 3:e955691

Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit immune responses specific for dead cell-associated antigens. However, multiple stimuli can trigger a functionally peculiar type of apoptotic demise that does n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e222b12ef30f7729b206437df90134bc
https://doi.org/10.4161/21624011.2014.955691