The Structure of the GM-CSF Receptor Complex Reveals a Distinct Mode of Cytokine Receptor Activation

Autor: William J. McKinstry, Michael W. Parker, Guido Hansen, Mark A. Guthridge, Frank C. Stomski, Jason A. Powell, Angel F. Lopez, Barbara J. McClure, Hayley S. Ramshaw, Joanna M. Woodcock, Mara Dottore, Yibin Xu, Timothy R. Hercus

Publikováno v: Cell. 134:496-507

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pleiotropic cytokine that controls the production and function of blood cells, is deregulated in clinical conditions such as rheumatoid arthritis and leukemia, yet offers therapeutic valu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3032121b1ceebf72ca2fed48bf54286
https://doi.org/10.1016/j.cell.2008.05.053

The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor

Autor: Omer Dushek, Facundo D. Batista, Andreas Bruckbauer, Aitor Gonzalez-Granja, Bebhinn Treanor, David Depoil, Michele Weber, Patricia Barral

SummaryEarly events of B cell activation after B cell receptor (BCR) triggering have been well characterized. However, little is known about the steady state of the BCR on the cell surface. Here, we simultaneously visualize single BCR particles and c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c3ac154eff3d6f7137bd9718d8aa88e
https://ora.ox.ac.uk/objects/uuid:9ef3c14b-1fde-4b40-8111-00b98151e74f

Constitutively active Lck kinase in T cells drives antigen receptor signal transduction

Autor: Cristiana Soldani, Lars Fugger, Thomas Höfer, Antonella Viola, Ruth Etzensperger, Mogjiborahman Salek, Oreste Acuto, Adrian Gray, Omer Dushek, Wolfgang Paster, Konstantina Nika, Paolo Polzella, Vincenzo Cerundolo

Publikováno v: Immunity; Vol 32
Nika, K, Soldani, C, Salek, M, Paster, W, Gray, A, Etzensperger, R, Fugger, L, Polzella, P, Cerundolo, V, Dushek, O, Höfer, T, Viola, A & Acuto, O 2010, ' Constitutively active Lck kinase in T cells drives antigen receptor signal transduction ', Immunity, vol. 32, no. 6, pp. 766-77 . https://doi.org/10.1016/j.immuni.2010.05.011
Immunity

Summary T cell antigen receptor (TCR) and coreceptor ligation is thought to initiate signal transduction by inducing activation of the kinase Lck. Here we showed that catalytically active Lck was present in unstimulated naive T cells and thymocytes a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634b984d1491b70db23b4de279adf9cd
https://ora.ox.ac.uk/objects/uuid:3261cb8e-a5bf-48d3-8292-5ef2a9b269e6

Fidelity of Pathogen-Specific CD4+ T Cells to the Th1 Lineage Is Controlled by Exogenous Cytokines, Interferon-γ Expression, and Pathogen Lifestyle

Autor: Kevin B. Urdahl, Amina Negash, Shahin Shafiani, Emily Rowell, Meredith M. Curtis, Sing Sing Way, Christopher B. Wilson

Publikováno v: Cell Host & Microbe. 8(2):163-173

The degree of lineage stability achieved by pathogen-specific CD4(+) T cells in vivo, and how this impacts host defense against infection, remains unclear. We demonstrate that in response to Th1-polarizing intracellular bacterial or viral pathogens,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26877edcb19b28bf73c47fc437b0fc0

Structural and Functional Studies of Igαβ and Its Assembly with the B Cell Antigen Receptor

Autor: Zhongcheng Zou, Pavel Tolar, Susan K. Pierce, Sergei Radaev, Anh Nguyen, Peter D. Sun, Nicole Stutzman, Peter D. Krueger, Khanh Q. Nguyen

Publikováno v: Structure. 18:934-943

The B cell antigen receptor (BCR) plays an essential role in all phases of B cell development. Here we show that the extracellular domains of murine and human Igbeta form an I-set immunoglobulin-like structure with an interchain disulfide between cys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818d57f8d677b893af72e8797d4ad95f
https://doi.org/10.1016/j.str.2010.04.019