Výsledky vyhledávání - "MOLECULAR LIBRARY"

Lipophilicity assessement in drug discovery: Experimental and theoretical methods applied to xanthone derivatives

Autor: Álvaro Almeida Santos, Sara Cravo, Carlos A. M. Afonso, Carla Fernandes, Maria Elizabeth Tiritan, Madalena Pinto, Salette Reis, José X. Soares

Publikováno v: Journal of Chromatography B
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

For the last several years, searching of new xanthone derivatives (XDs) with potential pharmacological activities has remained one of the main areas of interest of our group. The optimization of biological activity and drug-like properties of hits an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc19fb7f65934023037480493d3d48de

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Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions

Autor: Monica Civera, Fabio Doro, Emilio Parisini, Umberto Piarulli, Roberto Fanelli, Leonardo Manzoni, Chiara Alberti, Elena Luison, Daniela Arosio, Cinzia Colombo, Antonella Tomassetti, Mariangela Figini, Laura Belvisi, Cesare Casagrande

Publikováno v: Organic & biomolecular chemistry 13 (2015): 2570–2573. doi:10.1039/C4OB02538E
info:cnr-pdr/source/autori:F. Doro, C. Colombo, C. Alberti, D. Arosio, L. Belvisi, C. Casagrande, R. Fanelli, L. Manzoni, E. Parisini, U. Piarulli, E. Luison, M. Figini, A. Tomassetti, M. Civera/titolo:Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions/doi:10.1039%2FC4OB02538E/rivista:Organic & biomolecular chemistry/anno:2015/pagina_da:2570/pagina_a:2573/intervallo_pagine:2570–2573/volume:13

We report a first set of peptidomimetic ligands mimicking the adhesive interface identified by recent crystallographic structures of E- and N-cadherin. Compounds 2 and 3 inhibit adhesion of epithelial ovarian cancer (EOC) cells with improved efficacy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd37d9990a2729425311bef18287bac
https://doi.org/10.1039/c4ob02538e

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Stepwise Construction of Heterobimetallic Cages by an Extended Molecular Library Approach

Autor: Matthias Hardy, Filip Topić, Gregor Schnakenburg, Niklas Struch, Kari Rissanen, Arne Lützen

Publikováno v: Inorganic chemistry. 57(7)

Two novel heterobimetallic complexes, a trigonal-bipyramidal and a cubic one, have been synthesized and characterized using the same C3-symmetric metalloligand, prepared by a simple subcomponent self-assembly strategy. Adopting the molecular library

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edcab48d3aa51d59925fa4a107a3662d
https://pubmed.ncbi.nlm.nih.gov/29185725

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Site-specific fluorescence polarization for studying the disaggregation of α-synuclein fibrils by small molecules

Autor: Merve Canyurt, Malcolm J. Daniels, Lily Owei, Jaclyn Robustelli, Tobias Baumgart, Christina L. Cleveland, Rebecca F. Wissner, Conor M. Haney, Harry Ischiropoulos, E. James Petersson, Priscilla Rodriguez

Publikováno v: Biochemistry

Fibrillar aggregates of the protein α-synuclein (αS) are one of the hallmarks of Parkinson’s disease. Here, we show that measuring the fluorescence polarization (FP) of labels at several sites on αS allows one to monitor changes in the local dyn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5937f32d619db234ae6a7d9735d21e
https://hdl.handle.net/11693/37311

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Ammonia-promoted one-pot tetrazolopiperidinone synthesis by Ugi reaction

Autor: Alexander Dömling, Justyna Kalinowska-Tłuścik, Pravin Patil, Katarzyna Kurpiewska

Publikováno v: ACS Combinatorial Science
Acs combinatorial science, 19(5), 343-350. AMER CHEMICAL SOC

Ammonia in the tetrazole Ugi variation together with α-amino acid methyl ester-derived isocyanides provides tetrazolopiperidinones in good to high yields in one pot. The scope and limitations of this reaction were investigated by performing >70 reac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::563b7c8c38ebb8f85d052b7e64b7dd0e
http://ruj.uj.edu.pl/xmlui/handle/item/42336

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Zebrafish models in neuropsychopharmacology and CNS drug discovery

Autor: Khan, K. M., Collier, A. D., Meshalkina, D. A., Kysil, E. V., Khatsko, S. L., Kolesnikova, T., Morzherin, Y. Y., Warnick, J. E., Kalueff, A. V., Echevarria, D. J.

Publikováno v: British Journal of Pharmacology

Despite the high prevalence of neuropsychiatric disorders, their aetiology and molecular mechanisms remain poorly understood. The zebrafish (Danio rerio) is increasingly utilized as a powerful animal model in neuropharmacology research and in vivo dr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______917::9cc1d1f23f26c40d783b159a3242c406
https://hdl.handle.net/10995/75103

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