Zobrazeno 1 - 10
of 1 093
pro vyhledávání: '"MOLECULAR DOCKING STUDIES"'
Autor:
Barghady Najoua, Assou Soumia Ait, Er-Rajy Mohammed, Boujdi Khalid, Arzine Aziz, Rhazi Yassine, Tüzün Burak, Nakkabi Asmae, Chalkha Mohammed, El Hassouni Mohammed, Kabra Atul, Alanazi Mohammed M., Baouid Abdesselam, El Yazidi Mohamed
Publikováno v:
Open Chemistry, Vol 22, Iss 1, Pp 279-83 (2024)
Externí odkaz:
https://doaj.org/article/fb004eb9056e4467b720dd48bf8fffec
Autor:
Gulam Muheyuddeen, Mohd Yaqub Khan, Tanzeem Ahmad, Shriyansh Srivastava, Stuti Verma, Mo. Suheb Ansari, Nilanchala Sahu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Imidazole moieties exhibit a broad range of biological activities, including analgesic, anti-depressant, anticancer, anti-fungal, anti-tubercular, anti-inflammatory, antimicrobial, antiviral, and antifungal properties. In this study, we expl
Externí odkaz:
https://doaj.org/article/6c4a424864594843a30a66dac9706cc6
Autor:
Zubair Ahmed, Muhammad Ikram, Ishaq Khan, Kashif Bashir, Abdul Jabbar Shah, Zahid Hussain, Taous Khan
Publikováno v:
Plant Methods, Vol 20, Iss 1, Pp 1-17 (2024)
Abstract Clematis graveolens Lindl., an indigenous climbing plant found in the Himalayan areas, is used by local communities for the treatment of neck tumors. The objective of this work is to examine the comprehensive metabolomic profile, antioxidant
Externí odkaz:
https://doaj.org/article/034a71abed3849a9b8fd00e838167a54
Autor:
Wesam S. Shehab, Hend A. Haikal, Doaa A. Elsayed, Ahmed F. EL-Farargy, Abdel-Rahman B. A. El-Gazzar, Gehan T. El-Bassyouni, Sahar M. Mousa
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Alzheimer disease (AD) is the cause of dementia and accounts for 60–80% cases. Tumor Necrosis Factor-alpha (TNF-α) is a multifunctional cytokine that provides resistance to infections, inflammation, and cancer. It developed as a prospecti
Externí odkaz:
https://doaj.org/article/fea56e1e25dd4541b38683f7695ed94d
Autor:
Mithlesh Yadav, Suraj N. Mali, Bharti Sharma, Haya Yasin, Rohit Pal, Gurubasavaraja Swamy Purawarga Matada, Archana Kapoor
Publikováno v:
Chemical Physics Impact, Vol 9, Iss , Pp 100705- (2024)
This study reports the synthesis and characterization of a novel series of 5-nitro-N-phenyl-3-(phenylamino)-1H-indazole-1-carboxamide derivatives (5a-5v) obtained through the reaction of 3-chloro-5-nitro-N-phenyl-1H-indazole-1-carboxamide (4) with di
Externí odkaz:
https://doaj.org/article/11de1dff598042a98ed188f2bdaac63d
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractIn this study, four series of piperazine derivatives were designed, synthesised and subjected to biological test, and compound 6a with potential antidepressant activity was obtained. An affinity assay of compound 6a with 5-hydroxytryptamine (
Externí odkaz:
https://doaj.org/article/895c3580ab554513b587867a61650fd5
Publikováno v:
Phytomedicine Plus, Vol 4, Iss 4, Pp 100665- (2024)
Background: DPP-4 inhibitors, are widely used clinically for treatment of Diabetes. Increase in circulating DPP4 levels have been well demonstrated in patients with Type 2 Diabetes mellitus. The present study assessed the contribution of DPP-4 axis t
Externí odkaz:
https://doaj.org/article/fa3d523272814b0db54502ea5f482a83
Autor:
Saima Daud, Obaid‐ur‐Rahman Abid, Malik Saadullah, M. Fakhar-e-Alam, Simone Carradori, Asma Sardar, Basit Niaz, M. Atif, Susi Zara, Muhammad Rashad
Publikováno v:
Journal of Saudi Chemical Society, Vol 28, Iss 5, Pp 101905- (2024)
α-Glucosidase and urease inhibitors have emerged as crucial for developing therapeutic drugs targeting diabetes and gastrointestinal disorders. This study reports on new series of ibuprofen and mefenamic acid Schiff base derivatives incorporating is
Externí odkaz:
https://doaj.org/article/5c9f22681980480a9138b33416292a60
Autor:
Jawaria Hafeez, Azka Sabir, Nasir Rasool, Usama Hafeez, Farhan Siddique, Muhammad Bilal, Aqsa Kanwal, Gulraiz Ahmad, Faleh Alqahtani, Imran Imran, Muhammad Imran
Publikováno v:
Arabian Journal of Chemistry, Vol 17, Iss 9, Pp 105889- (2024)
A new series of N, N-bis([1,1′-biphenyl]-4-ylmethyl)-4-morpholinoaniline derivatives (6a − h, 7i) were synthesized and evaluated their anticonvulsant potential through in vivo and in silico studies. 6 Hz Psychomotor and acute pentylenetetrazol (P
Externí odkaz:
https://doaj.org/article/9d61b04c873944bbbc848deb484c3498
Autor:
Fathy M. Abdelrazek, Magdi E.A. Zaki, Sami A. Al-Hussain, Basant Farag, Ali M. Hebishy, Mohamed S. Abdelfattah, Safaa M. Hassan, Ahmed F. El-Farargy, Lyuba Iovkova, David Mross, Sobhi M. Gomha
Publikováno v:
Heliyon, Vol 10, Iss 7, Pp e29221- (2024)
4-Acetylpyridine 1 and malononitrile 2 were allowed to react in a 3MCRs with dimedone 3a or cyclohexa-1,3-dione 3b under reflux to afford 4-methyl-4-(pyridin-4-yl)-5,6,7,8-tetrahydro-4H-chromene derivatives 4a,b respectively. The mechanism of the rea
Externí odkaz:
https://doaj.org/article/58795c44d28d4dd399a6cf8e74977e8e