Zobrazeno 1 - 10
of 30
pro vyhledávání: '"MOHSIN RAHIM"'
Autor:
Tomasz K. Bednarski, Mohsin Rahim, Clinton M. Hasenour, Deveena R. Banerjee, Irina A. Trenary, David H. Wasserman, Jamey D. Young
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 6, Pp 100558- (2024)
Metabolic dysfunction-associated steatotic liver disease is the most common form of liver disease and poses significant health risks to patients who progress to metabolic dysfunction-associated steatohepatitis. Fatty acid overload alters endoplasmic
Externí odkaz:
https://doaj.org/article/c47f295c40d14743bbad10fcd129e345
Autor:
Mohsin Rahim, Clinton M. Hasenour, Tomasz K. Bednarski, Curtis C. Hughey, David H. Wasserman, Jamey D. Young
Publikováno v:
JCI Insight, Vol 6, Iss 12 (2021)
The liver is the major source of glucose production during fasting under normal physiological conditions. However, the kidney may also contribute to maintaining glucose homeostasis in certain circumstances. To test the ability of the kidney to compen
Externí odkaz:
https://doaj.org/article/e38a1f84ddad44a6850efd5dbd70d9e4
Autor:
Karin J. Bosma, Mohsin Rahim, James K. Oeser, Owen P. McGuinness, Jamey D. Young, Richard M. O'Brien
Publikováno v:
Molecular Metabolism, Vol 41, Iss , Pp 101043- (2020)
Objective: G6PC2 is predominantly expressed in pancreatic islet beta cells. G6PC2 hydrolyzes glucose-6-phosphate to glucose and inorganic phosphate, thereby creating a futile substrate cycle that opposes the action of glucokinase. This substrate cycl
Externí odkaz:
https://doaj.org/article/4701c9a4aec148bc85868d0b7a48679f
Publikováno v:
Cell Reports, Vol 32, Iss 5, Pp 107986- (2020)
Summary: Isotope-based assessment of metabolic flux is achieved through a judicious balance of measurements and assumptions. Recent publications debate the validity of key assumptions used to model stable isotope labeling of liver metabolism in vivo.
Externí odkaz:
https://doaj.org/article/1be4c676b4eb46bea35bb7439aab217e
Autor:
Kalyan C. Vinnakota, Venkat R. Pannala, Martha L. Wall, Mohsin Rahim, Shanea K. Estes, Irina Trenary, Tracy P. O’Brien, Richard L. Printz, Jaques Reifman, Masakazu Shiota, Jamey D. Young, Anders Wallqvist
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
The liver—a central metabolic organ that integrates whole-body metabolism to maintain glucose and fatty-acid regulation, and detoxify ammonia—is susceptible to injuries induced by drugs and toxic substances. Although plasma metabolite profiles ar
Externí odkaz:
https://doaj.org/article/31160d3a38544dea8291b4a19412e827
Autor:
Venkat R. Pannala, Shanea K. Estes, Mohsin Rahim, Irina Trenary, Tracy P. O’Brien, Chiyo Shiota, Richard L. Printz, Jaques Reifman, Masakazu Shiota, Jamey D. Young, Anders Wallqvist
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 21, p 8250 (2020)
Liver disease and disorders associated with aberrant hepatocyte metabolism can be initiated via drug and environmental toxicant exposures. In this study, we tested the hypothesis that gene and metabolic profiling can reveal commonalities in liver res
Externí odkaz:
https://doaj.org/article/a8b21068dd5646fbae4799f778e14115
Autor:
Gaurav Sharma, Nesmine Maptue, Mohsin Rahim, Miriam L. Trigo Mijes, Thomas Hever, Xiaodong Wen, Alexander M. Funk, Craig R. Malloy, Jamey D. Young, Chalermchai Khemtong
Publikováno v:
NMR in Biomedicine. 36
Publikováno v:
Current Opinion in Biotechnology. 71:1-8
Identifying the factors and mechanisms that regulate metabolism under normal and diseased states requires methods to quantify metabolic fluxes of live tissues within their physiological milieu. A number of recent developments have expanded the reach
Autor:
Gaurav Sharma, Nesmine Maptue, Mohsin Rahim, Miriam L. Trigo Mijes, Thomas Hever, Xiaodong Wen, Alexander M. Funk, Craig R. Malloy, Jamey D. Young, Chalermchai Khemtong
Publikováno v:
NMR in Biomedicine. 36
Publikováno v:
Diabetes. 71
The metabolic complications of obesity are distributed throughout the body, yet studies assessing its impact on metabolic fluxes have primarily focused on single tissues. Here we use a 13C tracer approach to simultaneously quantify metabolic flux dys