Zobrazeno 1 - 10
of 12 956
pro vyhledávání: '"MODEL ORGANISM"'
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Background CRISPR-Cas systems require a protospacer adjacent motif (PAM), which plays an essential role in self/non-self discrimination in their natural context, to cleave DNA for genome editing. Unfortunately, common genetic variation is di
Externí odkaz:
https://doaj.org/article/752c068f66a04c38bd2aedbe529f4e66
Publikováno v:
BMC Bioinformatics, Vol 25, Iss S2, Pp 1-15 (2024)
Abstract Background Conventional differential gene expression analysis pipelines for non-model organisms require computationally expensive transcriptome assembly. We recently proposed an alternative strategy of directly aligning RNA-seq reads to a pr
Externí odkaz:
https://doaj.org/article/be4eff8e04bf4b17b00e898db06e75f0
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-15 (2024)
Abstract Background The family Batrachoididae are a group of ecologically important teleost fishes with unique life histories, behavior, and physiology that has made them popular model organisms. Batrachoididae remain understudied in the realm of gen
Externí odkaz:
https://doaj.org/article/6ecf64f0608b4e9998084a3793613d89
Autor:
Nurdan Filik
Publikováno v:
Laboratuvar Hayvanları Bilimi ve Uygulamaları Dergisi, Vol 4, Iss 2, Pp 53-59 (2024)
ABSTRACTVirtually every major medical advance of the last century and at still has depended upon research with animals. Zebrafish's journey from the ocean to the laboratory leads to major scientific breakthroughs. Transparency structure of zebrafish
Externí odkaz:
https://doaj.org/article/986b06ba5efa40abbc6fc2ce8e93a84a
Autor:
Myra N. Chávez, Prateek Arora, Marco Meer, Ines J. Marques, Alexander Ernst, Rodrigo A. Morales Castro, Nadia Mercader
Publikováno v:
iScience, Vol 27, Iss 12, Pp 111406- (2024)
Summary: Autophagy-lysosomal degradation is a conserved homeostatic process considered to be crucial for cardiac morphogenesis. However, both its cell specificity and functional role during heart development remain unclear. Here, we introduced zebraf
Externí odkaz:
https://doaj.org/article/60869df8fb554298b03dc5dc463b6eba
Autor:
Chunhua Dai, Yue Zhang, Yulong Gong, Amber Bradley, Zihan Tang, Katelyn Sellick, Shristi Shrestha, Erick Spears, Brittney A. Covington, Jade Stanley, Regina Jenkins, Tiffany M. Richardson, Rebekah A. Brantley, Katie Coate, Diane C. Saunders, Jordan J. Wright, Marcela Brissova, E. Danielle Dean, Alvin C. Powers, Wenbiao Chen
Publikováno v:
iScience, Vol 27, Iss 12, Pp 111447- (2024)
Summary: Increased blood amino acid levels (hyperaminoacidemia) stimulate pancreas expansion by unclear mechanisms. Here, by genetic and pharmacological disruption of glucagon receptor (GCGR) in mice and zebrafish, we found that the ensuing hyperamin
Externí odkaz:
https://doaj.org/article/2ee032232bfd42259a0d71c3c02e2ba8
Autor:
Jordan N. Reed, Faten Hasan, Abhishek Karkar, Dhanush Banka, Jameson Hinkle, Preeti Shastri, Navya Srivastava, Steven C. Scherping, Sarah E. Newkirk, Heather A. Ferris, Bijoy K. Kundu, Sibylle Kranz, Mete Civelek, Susanna R. Keller
Publikováno v:
iScience, Vol 27, Iss 12, Pp 111323- (2024)
Summary: In humans, dietary patterns impact weight and metabolism differentially across individuals. To uncover genetic determinants for differential dietary effects, we subjected four genetically diverse mouse strains to humanized diets (American, M
Externí odkaz:
https://doaj.org/article/7ed07bee20334d349e393cd8d8a3aa49
Autor:
Valentina Peona, Jacopo Martelossi, Dareen Almojil, Julia Bocharkina, Ioana Brännström, Max Brown, Alice Cang, Tomàs Carrasco-Valenzuela, Jon DeVries, Meredith Doellman, Daniel Elsner, Pamela Espíndola-Hernández, Guillermo Friis Montoya, Bence Gaspar, Danijela Zagorski, Paweł Hałakuc, Beti Ivanovska, Christopher Laumer, Robert Lehmann, Ljudevit Luka Boštjančić, Rahia Mashoodh, Sofia Mazzoleni, Alice Mouton, Maria Anna Nilsson, Yifan Pei, Giacomo Potente, Panagiotis Provataris, José Ramón Pardos-Blas, Ravindra Raut, Tomasa Sbaffi, Florian Schwarz, Jessica Stapley, Lewis Stevens, Nusrat Sultana, Radka Symonova, Mohadeseh S. Tahami, Alice Urzì, Heidi Yang, Abdullah Yusuf, Carlo Pecoraro, Alexander Suh
Publikováno v:
Mobile DNA, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Background The advancement of sequencing technologies results in the rapid release of hundreds of new genome assemblies a year providing unprecedented resources for the study of genome evolution. Within this context, the significance of in-d
Externí odkaz:
https://doaj.org/article/5b725ff7c4734dbd97e9756237a1869f
Autor:
Sun, Yuling 1, Yu, Huidi 1, Zhan, Zhihao 1, Liu, Wei 1, Liu, Penggang 1, Sun, Jing 1, Zhang, Pinghu 2, Wang, Xiaoquan 3, 4, Liu, Xiufan 3, 4, Xu, Xiulong 1, 4, 5, ∗
Publikováno v:
In iScience 17 January 2025 28(1)
Autor:
Yamauchi, Ichiro 1, 6, ∗, Sugawa, Taku 1, Hakata, Takuro 1, Yoshizawa, Akira 2, Kita, Tomoko 2, Kishimoto, Yo 2, Kimura, Sadahito 1, Sakurai, Aya 1, Kosugi, Daisuke 1, Fujita, Haruka 1, Okamoto, Kentaro 1, Ueda, Yohei 1, Fujii, Toshihito 1, Taura, Daisuke 1, Sakane, Yoriko 1, 3, Yasoda, Akihiro 4, Inagaki, Nobuya 5
Publikováno v:
In iScience 17 January 2025 28(1)