Zobrazeno 1 - 10 of 22 pro vyhledávání: '"MODEL AD"'
1
Akademický článek
A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s disease
Autor: Christoph Preuss, Ravi Pandey, Erin Piazza, Alexander Fine, Asli Uyar, Thanneer Perumal, Dylan Garceau, Kevin P. Kotredes, Harriet Williams, Lara M. Mangravite, Bruce T. Lamb, Adrian L. Oblak, Gareth R. Howell, Michael Sasner, Benjamin A. Logsdon, the MODEL-AD Consortium, Gregory W. Carter
Publikováno v: Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-16 (2020)
Abstract Background Late-onset Alzheimer’s disease (LOAD) is the most common form of dementia worldwide. To date, animal models of Alzheimer’s have focused on rare familial mutations, due to a lack of frank neuropathology from models based on com
Externí odkaz: https://doaj.org/article/8775aca8b63c4f6aa8ee61934f0936b1
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2
Akademický článek
Improving preclinical to clinical translation in Alzheimer's disease research
Autor: Stacey J. Sukoff Rizzo, Andi Masters, Kristen D. Onos, Sara Quinney, Michael Sasner, Adrian Oblak, Bruce T. Lamb, Paul R Territo, for the MODEL‐AD consortium
Publikováno v: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction Preclinical testing in animal models is a critical component of the drug discovery and development process. While hundreds of interventions have demonstrated preclinical efficacy for ameliorating cognitive impairments in animal
Externí odkaz: https://doaj.org/article/0fffa4ae67c24532bed0c7d1b37ebc66
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3
Akademický článek
Model organism development and evaluation for late‐onset Alzheimer's disease: MODEL‐AD
Autor: Adrian L. Oblak, Stefania Forner, Paul R. Territo, Michael Sasner, Gregory W. Carter, Gareth R. Howell, Stacey J. Sukoff‐Rizzo, Benjamin A. Logsdon, Lara M. Mangravite, Ali Mortazavi, David Baglietto‐Vargas, Kim N. Green, Grant R. MacGregor, Marcelo A. Wood, Andrea J. Tenner, Frank M. LaFerla, Bruce T. Lamb, and The MODEL‐AD, Consortium
Publikováno v: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)
Abstract Alzheimer's disease (AD) is a major cause of dementia, disability, and death in the elderly. Despite recent advances in our understanding of the basic biological mechanisms underlying AD, we do not know how to prevent it, nor do we have an a
Externí odkaz: https://doaj.org/article/82d8538d9c6f4b1592fcdc36f7060ab7
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