Zobrazeno 1 - 10
of 424
pro vyhledávání: '"MMGBSA"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Citrobacter koseri causes infection in people who are immunocompromised. Without effective antibiotics, these infections can become severe and life-threatening, so effective drugs are essential to treat these infections. Utilizing subtractiv
Externí odkaz:
https://doaj.org/article/6f12c089c9d743dd97cdba04bb59fede
Autor:
Kannan Raman, Rajagopal Kalirajan, Fahadul Islam, Srikanth Jupudi, Divakar Selvaraj, Gomathi Swaminathan, Laliteshwar Pratap Singh, Ritesh Rana, Shopnil Akash, Md. Rezaul Islam, Firzan Nainu, Talha Bin Emran, Turki M. Dawoud, Mohammed Bourhia, Musaab Dauelbait, Rashu Barua
Publikováno v:
ChemistryOpen, Vol 13, Iss 10, Pp n/a-n/a (2024)
Abstract In the present work, phytoconstituents from Citrus limon are computationally tested against SARS‐CoV‐2 target protein such as Mpro ‐ (5R82.pdb), Spike ‐ (6YZ5.pdb) &RdRp ‐ (7BTF.pdb) for COVID‐19. Docking was done by glide model,
Externí odkaz:
https://doaj.org/article/5ba4d384037e4eeab8b401e4ea8377ab
Publikováno v:
Future Journal of Pharmaceutical Sciences, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Background Cucurbitacins are present in some common vegetables as secondary metabolites and are used by the plants against harmful microbes. Exploration of this capability of natural product based substances against wide variety of microbes
Externí odkaz:
https://doaj.org/article/8de9c7be4f3d4fbd99b1427fb766478a
Autor:
Rahul D. Jawarkar, Suraj N. Mali, Rahul G. Ingle, Sami A. Al-Hussain, Aamal A. Al-Mutairi, Prashant Deshmukh, Magdi E.A. Zaki
Publikováno v:
Chemical Physics Impact, Vol 9, Iss , Pp 100720- (2024)
Many human disorders include NF-kB signaling pathways, making IKK a therapeutic target in cancer treatment. Inflammatory illnesses and cancer are examples. COVID-19 is one of several triggers that stimulate NF-kB signaling. The activation of the NF-k
Externí odkaz:
https://doaj.org/article/a898a66ef6604217b85a49b0410a810a
Autor:
Rahul D. Jawarkar, Praveen Sharma, Sachin Jain, Umang Shah, Magdi EA Zaki, Sami A Al-Hussain, Suraj Mali, Chin-Hung Lai, Vijay H. Masand, Vivek T Humne
Publikováno v:
Journal of Taibah University for Science, Vol 18, Iss 1 (2024)
Oncology research progresses, yet cancer remains the largest medical need. The use of a medication with an accessible lead molecule shows great potential for long-term cancer therapy. It may help target cancer therapy and drug resistance. This work u
Externí odkaz:
https://doaj.org/article/4d6e5a30a06a4cff8782a5aedfba4cca
Autor:
Mbah Bake Maraf, Bel Youssouf G. Mountessou, Tsahnang Fofack Hans Merlin, Pouyewo Ariane, Joëlle Nadia Nouping Fekoua, Takoua Bella Jean Yves, Tchuifon Tchuifon Donald Raoul, Auguste Abouem A Zintchem, Gouet Bebga, Ndassa Ibrahim Mbouombouo, Ponnadurai Ramasami
Publikováno v:
Heliyon, Vol 10, Iss 9, Pp e29560- (2024)
We investigated 1012 molecules from natural products previously isolated from the South African biodiversity (SANCDB, https://sancdb.rubi.ru.ac.za/), for putative inhibition of Onchocerca volvulus pi-class glutathione S-transferase (Ov-GST2) by virtu
Externí odkaz:
https://doaj.org/article/8e3bafaebf0a4d13b6ad752908734e54
Autor:
Faizan Ahmad
Publikováno v:
Aging Medicine, Vol 6, Iss 3, Pp 272-280 (2023)
Abstract Objective This study aims to find the most promising Ganoderma lucidium targeting LRRK2 involved in PD. Methods First ADMET analysis was performed for five compounds followed by molecular docking of each compound. Then, we perform molecular
Externí odkaz:
https://doaj.org/article/9da2a598c109430ca5977f06ebf34551
Publikováno v:
Aging Medicine, Vol 6, Iss 2, Pp 144-154 (2023)
Abstract Objective Alzheimer's disease (AD) is one of the most prevalent neurological ailments, affecting around 50 million individuals globally. The condition is characterized by nerve cell damage due to the formation of amyloid‐beta plaques and n
Externí odkaz:
https://doaj.org/article/235336c874504c388abd1cdba6cecf92
Autor:
Nasim Ahmed, Partha Biswas, Md. Roman Mogal, Md. Rifat Sarker, Md. Mohaimenul Islam Tareq, Sabbir Ahmed, Mahfuza Akter, Md. Thandu Miah, Netish Kumar Kundo, Md. Nazmul Hasan, Md. Nurul Islam
Publikováno v:
Informatics in Medicine Unlocked, Vol 47, Iss , Pp 101493- (2024)
Pneumonia, an infectious lung disease, is a significant global health concern, claiming the lives of 740,180 children in 2019, which accounts for 14 % of pediatric deaths. Recently, the management of pediatric pneumonia has become complex due to expo
Externí odkaz:
https://doaj.org/article/68334f6b148e4ef991ec3b372b58bf97
Autor:
Ram Lal Swagat Shrestha, Binita Maharjan, Timila Shrestha, Bishnu Prasad Marasini, Jhashanath Adhikari Subin
Publikováno v:
Results in Chemistry, Vol 7, Iss , Pp 101363- (2024)
Govaniadine, an isoquinoline alkaloid first isolated from Corydalis govaniana Wall., has been reported to possess multiple biological properties. Its potential as a possible dopamine receptor D1 modulator has been assessed in this research work along
Externí odkaz:
https://doaj.org/article/f0d194f1bf304320a1360301f6e3004a