Zobrazeno 1 - 10 of 24 pro vyhledávání: '"MM Hettich"'
2
Role of Wnt-5a in the Determination of Human Mesenchymal Stem Cells into Preadipocytes
Autor: M. Udelhoven, Matthias Gomolka, MM Hettich, Axel Heidenreich, Wilhelm Krone, Matthias Laudes, R. Bilkovski, Christian A. Gutschow, Dominik M. Schulte, Bernhard Roth, F. Oberhauser
Publikováno v: Journal of Biological Chemistry. 285:6170-6178
Increasing adipocyte size as well as numbers is important in the development of obesity and type 2 diabetes, with adipocytes being generated from mesenchymal precursor cells. This process includes the determination of mesenchymal stem cells (MSC) int
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e171d49ecc1e680ee742ba6e01ee27
https://doi.org/10.1074/jbc.m109.054338
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3
Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's disease
Autor: Johanna Zemva, Katharina Schilbach, Jens C. Brüning, Marianne B. Ernst, Lorna Moll, M. Udelhoven, F. Thomas Wunderlich, O Stöhr, Susanna Freude, Wilhelm Krone, MM Hettich, Markus Schubert
Publikováno v: Journal of water and environment technology 35(1), 83-101 (2011). doi:10.1007/s11357-011-9333-2
In brains from patients with Alzheimer’s disease (AD), expression of insulin receptor (IR), insulin-like growth factor-1 receptor (IGF-1R), and insulin receptor substrate proteins is downregulated. A key step in the pathogenesis of AD is the accumu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f098bf376dbf7298e5714482d4e5f3
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4
Neuron-specific deletion of a single copy of the insulin-like growth factor-1 receptor gene reduces fat accumulation during aging
Autor: Wilhelm Krone, Susanna Freude, Johanna Zemva, MM Hettich, H. S. Brönneke, Katharina Schilbach, Markus Schubert
Publikováno v: Hormone and metabolic research 44(02), 99-104 (2011). doi:10.1055/s-0031-1298018
Insulin, insulin-like growth factor-1 (IGF-1), and leptin signaling have been proposed to play an important role in regulating energy homeostasis. In order to specifically address the role of neuronal IGF-1 receptor (IGF-1R) signaling for energy expe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::366e5aa171e8e267717300aaa093b1e8
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9
IRS-2 branch of IGF-1 receptor signaling is essential for appropriate timing of myelination
Autor: Markus Schubert, Kazuyuki Tobe, Takashi Kadowaki, Hannsjörg Schröder, Marita Müller, M. Udelhoven, Wilhelm Krone, Jens C. Brüning, Katharina Schilbach, Susanna Freude, U. Leeser, MM Hettich, Christoph Köhler
Publikováno v: Journal of neurochemistry. 107(4)
Insulin-like growth factor (IGF)-1 increases proliferation, inhibits apoptosis and promotes differentiation of oligodendrocytes and their precursor cells, indicating an important function for IGF-1 receptor (IGF-1R) signaling in myelin development. T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74af75b24f1bfd19879cbaea51ca1ded
https://pubmed.ncbi.nlm.nih.gov/18717815
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