Zobrazeno 1 - 10
of 168
pro vyhledávání: '"MLL rearrangement"'
Autor:
Lu Bai, Yong-zhan Zhang, Chen-hua Yan, Yu Wang, Lan-ping Xu, Xiao-hui Zhang, Le-ping Zhang, Xiao-jun Huang, Yi-fei Cheng
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background The presence of mixed-lineage leukaemia rearrangement (MLL-r) in paediatric patients with acute myeloid leukaemia (AML) is a poor prognostic predictor. Whether allogeneic haematopoietic stem cell transplantation (allo-HSCT) is ben
Externí odkaz:
https://doaj.org/article/1c35122f978343678dfcf5f60cb21ace
Autor:
Farinoosh Dadrass, Fatema Esmail, Aayushma Regmi, Kumaran Mudaliar, Kamran M. Mirza, Ameet R. Kini, Wendy Kim, Patrick Hagen, Nasheed M. Hossain
Publikováno v:
Clinical Case Reports, Vol 10, Iss 8, Pp n/a-n/a (2022)
Abstract Acute myeloid leukemia (AML) arises from clonal expansion of malignant hematopoietic precursor cells in the bone marrow. In rare instances, AML can recur with prominent extramedullary manifestations (i.e., leukemia cutis or myeloid sarcoma),
Externí odkaz:
https://doaj.org/article/3fcdc061c12f4cf0b84b8f40a5e5c485
Publikováno v:
Pediatric Reports, Vol 13, Iss 1, Pp 9-14 (2020)
About 2–5% of acute lymphoblastic leukemia (ALL) cases in pediatric patients are infants with an unfavorable prognosis because of high relapse probability. Early detection of the disease is, therefore, very important. Despite the fact that leukemia
Externí odkaz:
https://doaj.org/article/827553cc329f41dc82ff627f7a68775e
Publikováno v:
Leukemia Research Reports, Vol 17, Iss , Pp 100306- (2022)
Mixed phenotype acute leukemia (MPAL) consists of a leukemia of two different lineages (myeloid, T, and/or B) co-occurring in the same tissue. KMT2A-rearrangement is rare and usually seen in B/myeloid MPAL. We report a unique case of T/myeloid MPAL w
Externí odkaz:
https://doaj.org/article/fca837bdc339413087450b1f47e06f27
Autor:
Lu-Lu Wang, Dehong Yan, Xue Tang, Mengqi Zhang, Shilin Liu, Ying Wang, Min Zhang, Guichi Zhou, Tonghui Li, Feifei Jiang, Xiaowen Chen, Feiqiu Wen, Sixi Liu, Huirong Mai
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundDespite much improvement in the treatment for acute lymphoblastic leukemia (ALL), childhood ALLs with MLL-rearrangement (MLL-r) still have inferior dismal prognosis. Thus, defining mechanisms underlying MLL-r ALL maintenance is critical for
Externí odkaz:
https://doaj.org/article/375965395a404c71added94d1bfc9218
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Objectives: This study aimed to identify unknown mixed lineage leukemia (MLL) translocation partner genes in a de novo patient with myelodysplastic syndrome (MDS) with t(11;22)(q23;q11) and investigate the clinical and molecular features of this pati
Externí odkaz:
https://doaj.org/article/1e2e2df0507a4524b3832db3361c478a
Publikováno v:
Онкогематология, Vol 13, Iss 4, Pp 8-16 (2019)
Objective of the study . Analysis of the treatment outcomes of patients with MLL rearrangements in the Republic of Belarus within protocols AML-MM-2000 and AML-MM-2006.Materials and methods . The study included 151 patients with newly diagnosed acute
Externí odkaz:
https://doaj.org/article/683dc87c0d87414a8d3d8c9cca4311a8
Publikováno v:
Leukemia Research Reports, Vol 6, Iss C, Pp 29-32 (2016)
Congenital leukemia is a rare event with a poor prognosis. We report a case of congenital leukemia with a cryptic rearrangement of MLL demonstrable only with RT-PCR. Interestingly, with treatment, the patient showed lineage plasticity of the leukemia
Externí odkaz:
https://doaj.org/article/c7a6f3ed76a149d6bb5b1d00627ddf77
Autor:
Eberle, Julia
Secondary leukemia is a side effect of chemotherapeutic treatment that can occur several years after initial therapy, e.g. doxorubicin or etoposide. Etoposide as well as other drugs like doxorubicin can induce secondary leukemia, which is known for p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bfe51b7afb1d7f5255ea7ef813eda07
Publikováno v:
Pediatric Reports
Pediatric Reports, Vol 13, Iss 2, Pp 9-15 (2021)
Pediatric Reports, Vol 13, Iss 2, Pp 9-15 (2021)
About 2–5% of acute lymphoblastic leukemia (ALL) cases in pediatric patients are infants with an unfavorable prognosis because of high relapse probability. Early detection of the disease is, therefore, very important. Despite the fact that leukemia