Inhibition of USP2 Enhances TRAIL-Mediated Cancer Cell Death through Downregulation of Survivin

Autor: Tak Gyeom Lee, Seon Min Woo, Seung Un Seo, Shin Kim, Jong-Wook Park, Young-Chae Chang, Taeg Kyu Kwon

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 16, p 12816 (2023)

Ubiquitin-specific protease 2 (USP2) is a deubiquitinase belonging to the USPs subfamily. USP2 has been known to display various biological effects including tumorigenesis and inflammation. Therefore, we aimed to examine the sensitization effect of U

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Pharmacological USP2 targeting suppresses ovarian cancer growth by potentiating apoptosis and ferroptosis.

Autor: Yang D; Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China., Liu X; Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China; Department of Gynecology, Zhongshan Hospital of Dalian University, Dalian, China., Yang Y; Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China., Long Y; Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China., Nan D; Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China., Shi B; Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China., Wang J; Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China., Yang M; Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China., Cong H; Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China., Xing L; Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China., Zhou F; Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China., Yuan Q; Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China., Ta N; Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China., Zhang Y; Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China., Ma R; Department of Radiation Oncology, The Second Affiliated Hospital, Dalian Medical University, China. Electronic address: maruilan2000@163.com., Liu F; Department of Oncology, The Second Affiliated Hospital, Dalian Medical University, China. Electronic address: liufang_dy@sina.com., Liu S; Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China. Electronic address: liusy@dmu.edu.cn.

Publikováno v: Archives of biochemistry and biophysics [Arch Biochem Biophys] 2024 Oct 30; Vol. 762, pp. 110193. Date of Electronic Publication: 2024 Oct 30.