Zobrazeno 1 - 10
of 120
pro vyhledávání: '"MK-212"'
Publikováno v:
IUBMB Life. 68:985-993
5-Hydroxytryptamine 2C (5-HT2C) receptor agonists have been suggested to possess an antipsychotic activity in several acute preclinical tests of antipsychotic drugs with low extra-pyramidal side effect liability. However, little is known about the lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e46b9ff771408bdb349172022a99e316
https://doi.org/10.1002/iub.1580
https://doi.org/10.1002/iub.1580
Publikováno v:
Psychiatry Research. 226:308-315
Serotonin (5-HT) 2C receptors in brain affect psychosis, reward, substance abuse, anxiety, other behaviors, appetite, body temperature, and other physiological measures. They also have been implicated in antipsychotic drug efficacy and side effects.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e7048e3748d29bb990e687859c8036
https://doi.org/10.1016/j.psychres.2015.01.007
https://doi.org/10.1016/j.psychres.2015.01.007
Publikováno v:
Behavioural Pharmacology. 20:720-730
Only a sub-group of human drug users progress from initial drug-taking to drug addiction. An important aspect of this progression is the influence of the learned association between the effects of the drug and the environment in which it is experienc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d331ffc3cfd562fdd3e3481d6381a8c
https://doi.org/10.1097/fbp.0b013e328333b266
https://doi.org/10.1097/fbp.0b013e328333b266
Autor:
Tamara G. Amstislavskaya, Nina K. Popova, E. G. Kuznetsova, V. V. Bulygina, Marina A. Tibeikina
Publikováno v:
Bulletin of Experimental Biology and Medicine. 142:594-597
A dose-dependent the effect of 5HT2C-receptor agonist MK-212 on mouse behavior was demonstrated. Intraperitoneal injection of MK-212 in high doses (0.5 and 1.0 mg/kg) increased blood level of corticosterone in mice and reduced their motor activity. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea153be4e51061dc48d95cf11e6c537
https://doi.org/10.1007/s10517-006-0427-2
https://doi.org/10.1007/s10517-006-0427-2
Autor:
Kathryn A. Cunningham, Shijing Liu
Publikováno v:
Drug and Alcohol Dependence. 81:275-282
Environmental cues can become classically conditioned to cocaine exposure and are known to contribute to drug craving and relapse in addicts. The 5-HT2C receptor (5-HT2C R) has been shown to control the behavioral effects of acute cocaine administrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dbb64cb6ebd021b8f8ec20e8c2e324e
https://doi.org/10.1016/j.drugalcdep.2005.07.007
https://doi.org/10.1016/j.drugalcdep.2005.07.007
Publikováno v:
Psychopharmacology. 179:393-401
Reports have indicated that administration of nicotine inhibits, while withdrawal of chronically administered nicotine augments effects of serotonergic 5HT2A/2C agonists.It was our objective to determine whether 5HT2A/2C agonists can modulate the dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be2df219b37c02d6b411f9c117e55b46
https://doi.org/10.1007/s00213-004-2035-z
https://doi.org/10.1007/s00213-004-2035-z
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 306:734-743
The serotonin2C (5-hydroxytryptamine2C; 5-HT2C) receptor (5-HT2CR) is found in abundance in dopamine (DA) mesocorticolimbic pathways and is one of the important target proteins that modulates the behavioral effects of cocaine. In the present study, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf5d5144ed7df9a015d1b564a6f9f8d
https://doi.org/10.1124/jpet.102.045716
https://doi.org/10.1124/jpet.102.045716
Publikováno v:
Behavioral Neuroscience. 117:212-221
The role of serotonin 5-HT 2 receptors (5-HT 2 R) in the discriminative stimulus effects of fenfluramine was investigated. Male Sprague-Dawley rats were trained to discriminate (±)-fenfluramine (2 mg/kg ip) from saline using a 2-lever, water-reinfor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07ffb115e56d5710f8de846bdbe484f4
https://doi.org/10.1037/0735-7044.117.2.212
https://doi.org/10.1037/0735-7044.117.2.212
Autor:
Connie Sanchez, J Arnt
Publikováno v:
Behavioural Pharmacology. 11:291-298
The effects of serotonin (5-HT) receptor ligands on the MK 212 (6-chloro-2[1-piperazinyl]pyrazine) discriminative stimulus and quipazine-induced head twitches were studied in rats. 5-HT1A (8-OH-DPAT) and preferential 5-HT2A (DOI) receptor agonists di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bacd002b249b22e44bf5c4785e2e015
https://doi.org/10.1097/00008877-200006000-00012
https://doi.org/10.1097/00008877-200006000-00012
Autor:
Jan Gommans, Berend Olivier, Robert A. A. Maes, Theo H. Hijzen, J.A. Bouwknecht, Chris L.E. Broekkamp, Hemmie H.G. Berendsen
Publikováno v:
Psychopharmacology. 140:496-502
A conditioned taste aversion (CTA) procedure in mice was used to investigate the stimulus effects of the serotonin reuptake inhibitors (SSRIs) fluvoxamine and fluoxetine. Fluvoxamine elicited a reliable CTA (ED50 = 24 mg/kg, SC) and a number of drugs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5453f12acc61b633cebb1c5564bd03f
https://doi.org/10.1007/s002130050794
https://doi.org/10.1007/s002130050794