Zobrazeno 1 - 10
of 151
pro vyhledávání: '"MK Whyte"'
Autor:
David H. Dockrell, J Callahan, Joby Cole, Patrícia Coelho, JB McCafferty, Dave Singh, Richard C. Budd, Martin A. Bewley, MK Whyte, Sarah R. Walmsley, Eilise M. Ryan
Publikováno v:
BTS/BALR/BLF Early Career Investigator Awards.
COPD is set to become the third leading cause of death globally by 2023. To date, we have no significant disease modifying therapies. COPD patients experience chronic inflammation and defective innate immunity, largely driven by macrophage dysfunctio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::347e4a81eea2f302f7bc071dfd7ce932
https://doi.org/10.1136/thorax-2020-btsabstracts.1
https://doi.org/10.1136/thorax-2020-btsabstracts.1
Autor:
K. Dhaliwal, Robert Grecian, Adam Byron, E. Gwyer Findlay, Margaret C. Frame, MK Whyte, Sarah R. Walmsley
Publikováno v:
Trials and new concepts in pleural disease.
Introduction Raised blood neutrophil-to-lymphocyte ratio (NLR) correlates with worse outcomes in NSCLC. Increasing evidence shows neutrophils are not the short-lived bystander they were once considered to be, but instead a persistent active player in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aec84ba033bc682c1721e7e41d8b969c
https://doi.org/10.1136/thorax-2020-btsabstracts.52
https://doi.org/10.1136/thorax-2020-btsabstracts.52
Autor:
Ann Marie Swart, Andrew M. Wilson, Anthony Cahn, Toby M. Maher, Edwin R. Chilvers, Allan Clark, Susan Stirling, David M. Livermore, Eme-Tipac Team, David R Thickett, William D. Fraser, MK Whyte, Helen Parfrey, Matthew Hammond
Publikováno v:
B16. ILD THERAPY II.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0002495e582bd1075a3a10ee5b9b363
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2753
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2753
Autor:
Ajm Howden, Ananda S. Mirchandani, Patrícia Coelho, Rebecca S. Dickinson, Tracie Plant, A von Kriegsheim, Wesley Vermaelen, Fiona Murphy, Doreen A. Cantrell, Emily R. Watts, Andrew J. Finch, Pranvera Sadiku, Jens L. Hukelmann, Robert Grecian, Duncan Humphries, MK Whyte, Eilise M. Ryan, Sarah R. Walmsley, Bart Ghesquière
Publikováno v:
Fuelling the fire: inflammation and infection in lung disease.
Introduction and objectives Acute Respiratory Distress Syndrome (ARDS) is characterised by neutrophil driven alveolar and vascular injury. Alveolar damage is associated with worsening hypoxia and increased mortality. Specific therapies targeting neut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23118e805361ece8dfe982507cc5cd4a
https://doi.org/10.1136/thorax-2019-btsabstracts2019.139
https://doi.org/10.1136/thorax-2019-btsabstracts2019.139
Autor:
Felix Ellett, Tracie Plant, Sarah R. Walmsley, S. Eamsamnarng, Ananda S. Mirchandani, MK Whyte, Leo M. Carlin, Fiona Murphy, Emily R. Watts, Jessie-May Morgan, Andrew J.W. Furley
Publikováno v:
BTS/BALR/BLF Early Career Investigators awards symposium.
Effective host responses to injury and infection require both rapid recruitment of neutrophils into tissues and timely inflammation resolution. Research currently focuses on initiation and resolution as distinct phases of inflammation and neutrophil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cb96187d8e79bfe07d9487bd7fd3b15
https://doi.org/10.1136/thorax-2018-212555.3
https://doi.org/10.1136/thorax-2018-212555.3
Autor:
David H. Dockrell, Richard C. Budd, PA Reid, G Choudhury, Eilise M. Ryan, William L. Rumsey, Yolanda Sanchez, Patrícia Coelho, Sarah R. Walmsley, Martin A. Bewley, MK Whyte
Publikováno v:
Mechanistic insights into COPD.
COPD patients have defective innate immunity, characterised in part by macrophage dysfunction. In established disease, both monocyte derived macrophages (MDM) and alveolar macrophages (AM), have impaired phagocytosis of bacteria and apoptotic cells (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4582d3fb01b6fb28b3917d06071874f4
https://doi.org/10.1136/thoraxjnl-2017-210983.121
https://doi.org/10.1136/thoraxjnl-2017-210983.121
Autor:
MK Whyte, V Finisguerra, Allan Lawrie, Massimilliano Mazzone, Randall S. Johnson, Julie A. Preston, Adriana Tavares, Aar Thompson, Simon J. Foster, Andrew S. Cowburn, Amy Lewis, Joseph A Willson, Richard R. Meehan, Lynne Williams, David H. Dockrell, Edwin R. Chilvers, Sarah R. Walmsley, Stuart J. Forbes, Abdul G. Hameed, Fiona Murphy, John P. Thomson, Helen M. Marriott, Roland H Stimson, Rebecca S. Dickinson
Publikováno v:
Thorax. 71:A61.2-A62
Introduction Systemic hypoxaemia and recurrent bacterial infections frequently co-exist in patients with acute and chronic lung disease and correlate with poor clinical outcomes. Inappropriate neutrophilic inflammation is regularly seen in these circ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e49ac1f90dfb0809bd855883519262f
https://doi.org/10.1136/thoraxjnl-2016-209333.110
https://doi.org/10.1136/thoraxjnl-2016-209333.110
Publikováno v:
C101. VIRAL PATHOGENESIS AND IMMUNITY.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfc1bcb0c57ea2e59e2bf3d29a8f2edb
https://doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a5168
https://doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a5168
Autor:
Simon S. Cross, Paul F. Mercer, Helen M. Marriott, David H. Dockrell, MK Whyte, Allan Lawrie, Rachel C. Chambers, Emmet E. McGrath
Publikováno v:
Thorax. 66:A51-A52
Introduction The concept of driving cellular apoptosis as a potential therapy for diseases characterised by inappropriate cellular persistence or proliferation is of widespread interest. We previously showed a death receptor ligand, TRAIL, accelerate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ea06f24cc1bd176668869c6b38e9e34
https://doi.org/10.1136/thoraxjnl-2011-201054b.111
https://doi.org/10.1136/thoraxjnl-2011-201054b.111
Publikováno v:
Europe PubMed Central
Oxygen derived free radicals (ODFRs), generated by eosinophils, neutrophils, alveolar macrophages and mast cells, have been proposed as important mediators of inflammatory damage in asthma. We attempted to assess the role of these free radicals in pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9992834a6d84fc84337b86f343a17bd7
http://europepmc.org/abstract/med/2606195
http://europepmc.org/abstract/med/2606195
