DI-055 Evaluation of tocilizumab response in rheumatoid arthritis. Comparision of the results with the clinical trial

Autor: R Morón Romero, LJ Martinez, CL Dávila Fajardo, X Diaz Villamarin, M Valle Corpas, D Blanquez Martinez, MJ Soto Pino, J Cabeza Barrera, E Raya Alvarez, Mdc Gonzalez Medina

Publikováno v: European Journal of Hospital Pharmacy. 23:A142.1-A142

Background Tocilizumab (TCZ) is a humanised monoclonal antibody inhibitor of interleukin 6 receptor, indicated in combination with methotrexate in the treatment of rheumatoid arthritis (RA) in patients with inadequate response or intolerance to prior

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc0ea85ffa75f264d27ba6c2f09d6366
https://doi.org/10.1136/ejhpharm-2016-000875.321

PKP-023 Interleukin 6 G >G genetic polymorphism (RS1800795) and the response to tocilizumab in rheumatoid arthritis patients

Autor: Mdc González-Medina, E Sánchez-Yáñez, MJ Soto-Pino, I Casas-Hidalgo, Luis Javier Martinez-Gonzalez, Cristina Lucía Dávila-Fajardo, A Gómez-Martín, M Domínguez-Cantero, J Cabeza-Barrera, X Díaz-Villamarín

Publikováno v: European Journal of Hospital Pharmacy. 23:A188.3-A189

Background Interleukin (IL)-6 is involved in the pathogenesis of rheumatoid arthritis (RA) via its broad effects on immune and inflammatory responses. Sustained IL-6 activity can cause tissue damage in different tissues. Previous studies have shown t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c119b80a50e88e2608fcda6d7f5de69f
https://doi.org/10.1136/ejhpharm-2016-000875.426

Correction: Polymorphisms at phase I-metabolizing enzyme and hormone receptor loci influence the response to anti-TNF therapy in rheumatoid arthritis patients.

Autor: Canet LM; Genomic Oncology Area, GENYO Centre for Genomics and Oncological Research, Pfizer / University of Granada / Andalusian Regional Government, PTS Granada, Granada, Spain., Sánchez-Maldonado JM; Genomic Oncology Area, GENYO Centre for Genomics and Oncological Research, Pfizer / University of Granada / Andalusian Regional Government, PTS Granada, Granada, Spain., Cáliz R; Genomic Oncology Area, GENYO Centre for Genomics and Oncological Research, Pfizer / University of Granada / Andalusian Regional Government, PTS Granada, Granada, Spain.; Rheumatology Department, Virgen de las Nieves University Hospital, Granada, Spain., Rodríguez-Ramos A; Genomic Oncology Area, GENYO Centre for Genomics and Oncological Research, Pfizer / University of Granada / Andalusian Regional Government, PTS Granada, Granada, Spain., Lupiañez CB; Genomic Oncology Area, GENYO Centre for Genomics and Oncological Research, Pfizer / University of Granada / Andalusian Regional Government, PTS Granada, Granada, Spain., Canhão H; CEDOC, EpiDoC Unit, NOVA Medical School and National School of Public Health, Universidade Nova de Lisboa, Lisbon, Portugal., Martínez-Bueno M; Area of Genomic Medicine, GENYO Centre for Genomics and Oncological Research, Pfizer / University of Granada / Andalusian Regional Government, Granada, Spain., Escudero A; Rheumatology Department, Reina Sofía Hospital/IMIBIC/University of Córdoba, Córdoba, Spain., Segura-Catena J; Genomic Oncology Area, GENYO Centre for Genomics and Oncological Research, Pfizer / University of Granada / Andalusian Regional Government, PTS Granada, Granada, Spain., Sorensen SB; The Danish Rheumatologic Biobank, the DANBIO Registry and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.; Faculty of Health and Medical Sciences, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Hetland ML; The Danish Rheumatologic Biobank, the DANBIO Registry and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.; Faculty of Health and Medical Sciences, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Soto-Pino MJ; Rheumatology Department, Virgen de las Nieves University Hospital, Granada, Spain., Ferrer MA; Rheumatology Department, Virgen de las Nieves University Hospital, Granada, Spain., García A; Rheumatology Department, Virgen de las Nieves University Hospital, Granada, Spain., Glintborg B; The Danish Rheumatologic Biobank, the DANBIO Registry and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.; Department of Rheumatology, Gentofte and Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark., Filipescu I; Rheumatology Department, University of Medicine and Pharmacy 'Iuliu Hatieganu', Cluj-Napoca, Romania., Pérez-Pampin E; Rheumatology Unit, University Hospital of Santiago de Compostela, Santiago de Compostela, Spain., González-Utrilla A; Rheumatology Department, Virgen de las Nieves University Hospital, Granada, Spain., Nevot MÁL; Immunology Department, Virgen de las Nieves University Hospital, Granada, Spain., Conesa-Zamora P; Clinical Analysis Department, Santa Lucía University Hospital, Cartagena, Spain., den Broeder A; Department of Human Genetics, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands., De Vita S; Department of Medical and Biological Sciences, Clinic of Rheumatology, University of Udine, Udine, Italy., Jacobsen SEH; The Danish Rheumatologic Biobank, the DANBIO Registry and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.; Faculty of Health and Medical Sciences, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Collantes-Estevez E; Rheumatology Department, Reina Sofía Hospital/IMIBIC/University of Córdoba, Córdoba, Spain., Quartuccio L; Department of Medical and Biological Sciences, Clinic of Rheumatology, University of Udine, Udine, Italy., Canzian F; Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany., Fonseca JE; Rheumatology and Metabolic Bone Diseases Department, Hospital de Santa Maria, CHLN, Lisbon, Portugal.; Rheumatology Research Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon Academic Medical Center, Lisbon, Portugal., Coenen MJH; Department of Human Genetics, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands., Andersen V; Focused Research Unit for Molecular Diagnostic and Clinical Research, IRS-Center Sonderjylland, Hospital of Southern Jutland, DK-6200, Aabenraa, Denmark.; Faculty of Health Sciences, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark., Sainz J; Genomic Oncology Area, GENYO Centre for Genomics and Oncological Research, Pfizer / University of Granada / Andalusian Regional Government, PTS Granada, Granada, Spain. juan.sainz@genyo.es.; Rheumatology Department, Virgen de las Nieves University Hospital, Granada, Spain. juan.sainz@genyo.es.

Publikováno v: The pharmacogenomics journal [Pharmacogenomics J] 2019 Dec; Vol. 19 (6), pp. 582.

Polymorphisms at phase I-metabolizing enzyme and hormone receptor loci influence the response to anti-TNF therapy in rheumatoid arthritis patients.

Autor: Canet LM; Genomic Oncology Area, GENYO Centre for Genomics and Oncological Research, Pfizer / University of Granada / Andalusian Regional Government, PTS Granada, Granada, Spain., Sánchez-Maldonado JM; Genomic Oncology Area, GENYO Centre for Genomics and Oncological Research, Pfizer / University of Granada / Andalusian Regional Government, PTS Granada, Granada, Spain., Cáliz R; Genomic Oncology Area, GENYO Centre for Genomics and Oncological Research, Pfizer / University of Granada / Andalusian Regional Government, PTS Granada, Granada, Spain.; Rheumatology Department, Virgen de las Nieves University Hospital, Granada, Spain., Rodríguez-Ramos A; Genomic Oncology Area, GENYO Centre for Genomics and Oncological Research, Pfizer / University of Granada / Andalusian Regional Government, PTS Granada, Granada, Spain., Lupiañez CB; Genomic Oncology Area, GENYO Centre for Genomics and Oncological Research, Pfizer / University of Granada / Andalusian Regional Government, PTS Granada, Granada, Spain., Canhão H; CEDOC, EpiDoC Unit, NOVA Medical School and National School of Public Health, Universidade Nova de Lisboa, Lisbon, Portugal., Martínez-Bueno M; Area of Genomic Medicine, GENYO Centre for Genomics and Oncological Research, Pfizer / University of Granada / Andalusian Regional Government, Granada, Spain., Escudero A; Rheumatology Department, Reina Sofía Hospital/IMIBIC/University of Córdoba, Córdoba, Spain., Segura-Catena J; Genomic Oncology Area, GENYO Centre for Genomics and Oncological Research, Pfizer / University of Granada / Andalusian Regional Government, PTS Granada, Granada, Spain., Sorensen SB; The Danish Rheumatologic Biobank, the DANBIO Registry and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.; Faculty of Health and Medical Sciences, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Hetland ML; The Danish Rheumatologic Biobank, the DANBIO Registry and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.; Faculty of Health and Medical Sciences, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Soto-Pino MJ; Rheumatology Department, Virgen de las Nieves University Hospital, Granada, Spain., Ferrer MA; Rheumatology Department, Virgen de las Nieves University Hospital, Granada, Spain., García A; Rheumatology Department, Virgen de las Nieves University Hospital, Granada, Spain., Glintborg B; The Danish Rheumatologic Biobank, the DANBIO Registry and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.; Department of Rheumatology, Gentofte and Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark., Filipescu I; Rheumatology Department, University of Medicine and Pharmacy 'Iuliu Hatieganu', Cluj-Napoca, Romania., Pérez-Pampin E; Rheumatology Unit, University Hospital of Santiago de Compostela, Santiago de Compostela, Spain., González-Utrilla A; Rheumatology Department, Virgen de las Nieves University Hospital, Granada, Spain., Nevot MÁL; Immunology Department, Virgen de las Nieves University Hospital, Granada, Spain., Conesa-Zamora P; Clinical Analysis Department, Santa Lucía University Hospital, Cartagena, Spain., Broeder AD; Department of Human Genetics, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands., De Vita S; Department of Medical and Biological Sciences, Clinic of Rheumatology, University of Udine, Udine, Italy., Jacobsen SEH; The Danish Rheumatologic Biobank, the DANBIO Registry and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.; Faculty of Health and Medical Sciences, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Collantes-Estevez E; Rheumatology Department, Reina Sofía Hospital/IMIBIC/University of Córdoba, Córdoba, Spain., Quartuccio L; Department of Medical and Biological Sciences, Clinic of Rheumatology, University of Udine, Udine, Italy., Canzian F; Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany., Fonseca JE; Rheumatology and Metabolic Bone Diseases Department, Hospital de Santa Maria, CHLN, Lisbon, Portugal.; Rheumatology Research Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon Academic Medical Center, Lisbon, Portugal., Coenen MJH; Department of Human Genetics, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands., Andersen V; Focused Research Unit for Molecular Diagnostic and Clinical Research, IRS-Center Sonderjylland, Hospital of Southern Jutland, DK-6200, Aabenraa, Denmark.; Faculty of Health Sciences, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark., Sainz J; Genomic Oncology Area, GENYO Centre for Genomics and Oncological Research, Pfizer / University of Granada / Andalusian Regional Government, PTS Granada, Granada, Spain. juan.sainz@genyo.es.; Rheumatology Department, Virgen de las Nieves University Hospital, Granada, Spain. juan.sainz@genyo.es.

Publikováno v: The pharmacogenomics journal [Pharmacogenomics J] 2019 Feb; Vol. 19 (1), pp. 83-96. Date of Electronic Publication: 2018 Oct 05.

Genetic variants within immune-modulating genes influence the risk of developing rheumatoid arthritis and anti-TNF drug response: a two-stage case-control study.

Autor: Canet LM; aGenomic Oncology Area bArea of Genomic Medicine, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government Departments of cRheumatology dImmunology, Virgen de las Nieves University Hospital, Granada eDepartment of Rheumatology, Reina Sofía Hospital/Maimónides Institut for Biomedical Research of CórdobaI (IMIBIC)/University of Córdoba, Córdoba fRheumatology Unit, University Hospital of Santiago de Compostela, Santiago de Compostela, Spain gRheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa hDepartment of Rheumatology, Santa Maria Hospital-CHLN, Lisbon, Portugal iRheumatology Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania., Cáliz R, Lupiañez CB, Canhão H, Martinez M, Escudero A, Filipescu I, Segura-Catena J, Soto-Pino MJ, Ferrer MA, García A, Romani L, Pérez-Pampin E, González-Utrilla A, López Nevot MÁ, Collantes E, Fonseca JE, Sainz J

Publikováno v: Pharmacogenetics and genomics [Pharmacogenet Genomics] 2015 Sep; Vol. 25 (9), pp. 432-43.