Zobrazeno 1 - 10 of 93 pro vyhledávání: '"MJ Sofia"'
2
Akademický článek
Rational Design of Macrocyclic Noncovalent Inhibitors of SARS-CoV-2 M pro from a DNA-Encoded Chemical Library Screening Hit That Demonstrate Potent Inhibition against Pan-Coronavirus Homologues and Nirmatrelvir-Resistant Variants.
Autor: Wang X; Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Gotchev D; Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Fan KY; Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Vega MM; Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Mani N; Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., McGovern-Gooch K; Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Cuconati A; Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Tercero B; Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Wang X; Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Carpino P; X-Chem Inc., 4800 Rue Levy Suite 200, Montreal, QC CA H4R 2P7, Canada., Maskos K; Proteros Biostructures GmbH, Bunsenstraße 7a, Martinsried, Bavaria 82152, Germany., Centrella PA; X-Chem Inc., 100 Beaver Street Suite 101, Waltham, Massachusetts 02453, United States., Schmitt A; Proteros Biostructures GmbH, Bunsenstraße 7a, Martinsried, Bavaria 82152, Germany., Preuss F; Proteros Biostructures GmbH, Bunsenstraße 7a, Martinsried, Bavaria 82152, Germany., Prasad A; Proteros Biostructures GmbH, Bunsenstraße 7a, Martinsried, Bavaria 82152, Germany., Chen CY; Proteros Biostructures GmbH, Bunsenstraße 7a, Martinsried, Bavaria 82152, Germany., Clark MA; X-Chem Inc., 100 Beaver Street Suite 101, Waltham, Massachusetts 02453, United States., Guilinger JP; X-Chem Inc., 100 Beaver Street Suite 101, Waltham, Massachusetts 02453, United States., Johnstone S; X-Chem Inc., 4800 Rue Levy Suite 200, Montreal, QC CA H4R 2P7, Canada., von König K; Proteros Biostructures GmbH, Bunsenstraße 7a, Martinsried, Bavaria 82152, Germany., Keefe AD; X-Chem Inc., 100 Beaver Street Suite 101, Waltham, Massachusetts 02453, United States., Liu J; X-Chem Inc., 100 Beaver Street Suite 101, Waltham, Massachusetts 02453, United States., Turcotte S; X-Chem Inc., 4800 Rue Levy Suite 200, Montreal, QC CA H4R 2P7, Canada., Zhang Y; X-Chem Inc., 100 Beaver Street Suite 101, Waltham, Massachusetts 02453, United States., Konz Makino DL; Proteros Biostructures GmbH, Bunsenstraße 7a, Martinsried, Bavaria 82152, Germany., Lam AM; Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Cole AG; Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Sofia MJ; Arbutus Biopharma Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Nov 14; Vol. 67 (21), pp. 19623-19667. Date of Electronic Publication: 2024 Oct 25.
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3
Akademický článek
Structure-Activity Relationships and Discovery of ( S )-5-( tert -Butyl)-11-(difluoromethoxy)-9-methoxy-2-oxo-1,2,5,6-tetrahydropyrido[2',1':2,3]imidazo[4,5- h ]quinoline-3-carboxylic Acid (AB-161), a Novel Orally Available and Liver-Centric HBV RNA Destabilizer.
Autor: Gotchev D; Arbutus Biopharma, Warminster, Pennsylvania 18974, United States., Chen S; Arbutus Biopharma, Warminster, Pennsylvania 18974, United States., Dugan B; Arbutus Biopharma, Warminster, Pennsylvania 18974, United States., Dorsey BD; Arbutus Biopharma, Warminster, Pennsylvania 18974, United States., Wang X; Arbutus Biopharma, Warminster, Pennsylvania 18974, United States., Sheraz M; Arbutus Biopharma, Warminster, Pennsylvania 18974, United States., Kowalski R; Arbutus Biopharma, Warminster, Pennsylvania 18974, United States., Liu F; Arbutus Biopharma, Warminster, Pennsylvania 18974, United States., Tang S; Arbutus Biopharma, Warminster, Pennsylvania 18974, United States., Chiu T; Arbutus Biopharma, Warminster, Pennsylvania 18974, United States., Harasym T; Arbutus Biopharma, Warminster, Pennsylvania 18974, United States., Graves IE; Arbutus Biopharma, Warminster, Pennsylvania 18974, United States., Thi EP; Arbutus Biopharma, Warminster, Pennsylvania 18974, United States., Mason JD; Arbutus Biopharma, Warminster, Pennsylvania 18974, United States., Overholt N; Arbutus Biopharma, Warminster, Pennsylvania 18974, United States., Dugyala R; Arbutus Biopharma, Warminster, Pennsylvania 18974, United States., Lam AM; Arbutus Biopharma, Warminster, Pennsylvania 18974, United States., Cole AG; Arbutus Biopharma, Warminster, Pennsylvania 18974, United States., Sofia MJ; Arbutus Biopharma, Warminster, Pennsylvania 18974, United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Nov 08. Date of Electronic Publication: 2024 Nov 08.
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4
Akademický článek
Preclinical and clinical antiviral characterization of AB-836, a potent capsid assembly modulator against hepatitis B virus.
Autor: Lam AM; Arbutus Biopharma Inc., Warminster, PA, USA. Electronic address: maniulam@gmail.com., Mani N; Arbutus Biopharma Inc., Warminster, PA, USA., Ardzinski A; Arbutus Biopharma Inc., Warminster, PA, USA., Stever K; Arbutus Biopharma Inc., Warminster, PA, USA., Cuconati A; Arbutus Biopharma Inc., Warminster, PA, USA., Micolochick Steuer H; Arbutus Biopharma Inc., Warminster, PA, USA., Thi EP; Arbutus Biopharma Inc., Warminster, PA, USA., Graves IE; Arbutus Biopharma Inc., Warminster, PA, USA., Espiritu CL; Arbutus Biopharma Inc., Warminster, PA, USA., Mesaros E; Arbutus Biopharma Inc., Warminster, PA, USA., Kultgen SG; Arbutus Biopharma Inc., Warminster, PA, USA., Fan K; Arbutus Biopharma Inc., Warminster, PA, USA., Cole AG; Arbutus Biopharma Inc., Warminster, PA, USA., Harasym TO; Arbutus Biopharma Inc., Warminster, PA, USA., Rijnbrand R; Arbutus Biopharma Inc., Warminster, PA, USA., Brown J; Arbutus Biopharma Inc., Warminster, PA, USA., Eley T; Arbutus Biopharma Inc., Warminster, PA, USA., Varughese T; Arbutus Biopharma Inc., Warminster, PA, USA., Gane E; Auckland Clinical Studies, Grafton, Auckland, New Zealand., Picchio G; Arbutus Biopharma Inc., Warminster, PA, USA., Sims KD; Arbutus Biopharma Inc., Warminster, PA, USA., Sofia MJ; Arbutus Biopharma Inc., Warminster, PA, USA.
Publikováno v: Antiviral research [Antiviral Res] 2024 Nov; Vol. 231, pp. 106010. Date of Electronic Publication: 2024 Sep 24.
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5
Akademický článek
Control of Hepatitis B Virus with Imdusiran, a Small Interfering RNA Therapeutic.
Autor: Thi EP; Arbutus Biopharma Inc. 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Ye X; Arbutus Biopharma Inc. 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Snead NM; Arbutus Biopharma Inc. 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Lee ACH; Arbutus Biopharma Inc. 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Micolochick Steuer HM; Arbutus Biopharma Inc. 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Ardzinski A; Arbutus Biopharma Inc. 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Graves IE; Arbutus Biopharma Inc. 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Espiritu C; Arbutus Biopharma Inc. 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Cuconati A; Arbutus Biopharma Inc. 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Abbott C; Arbutus Biopharma Inc. 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Jarosz A; Arbutus Biopharma Inc. 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Teng X; Arbutus Biopharma Inc. 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Paratala B; Arbutus Biopharma Inc. 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., McClintock K; Arbutus Biopharma Inc. 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Harasym T; Arbutus Biopharma Inc. 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Rijnbrand R; Arbutus Biopharma Inc. 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Lam AM; Arbutus Biopharma Inc. 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Sofia MJ; Arbutus Biopharma Inc. 701 Veterans Circle, Warminster, Pennsylvania 18974, United States.
Publikováno v: ACS infectious diseases [ACS Infect Dis] 2024 Oct 11; Vol. 10 (10), pp. 3640-3649. Date of Electronic Publication: 2024 Sep 22.
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6
Akademický článek
Rational Design, Synthesis, and Structure-Activity Relationship of a Novel Isoquinolinone-Based Series of HBV Capsid Assembly Modulators Leading to the Identification of Clinical Candidate AB-836.
Autor: Cole AG; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Kultgen SG; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Mani N; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Fan KY; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Ardzinski A; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Stever K; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Dorsey BD; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Mesaros EF; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Thi EP; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Graves I; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Tang S; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Harasym TO; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Lee ACH; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Olland A; Xtal BioStructures Inc., 12 Michigan Drive, Natick, Massachusetts 01760, United States., Suto RK; Xtal BioStructures Inc., 12 Michigan Drive, Natick, Massachusetts 01760, United States., Sofia MJ; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Sep 26; Vol. 67 (18), pp. 16773-16795. Date of Electronic Publication: 2024 Sep 04.
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7
Akademický článek
Conformationally Constrained Isoquinolinones as Orally Efficacious Hepatitis B Capsid Assembly Modulators.
Autor: Mesaros EF; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Cole AG; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Kultgen SG; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Mani N; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Fan KY; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Dugan BJ; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Ardzinski A; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Stever K; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Micolochick Steuer HM; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Graves I; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Tang S; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Harasym TO; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Lam AM; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Thi EP; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Dorsey BD; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Sofia MJ; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States.
Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2024 Sep 03; Vol. 15 (9), pp. 1627-1634. Date of Electronic Publication: 2024 Sep 03 (Print Publication: 2024).
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8
Akademický článek
Discovery of C -Linked Nucleoside Analogues with Antiviral Activity against SARS-CoV-2.
Autor: Mesaros EF; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Dugan BJ; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Gao M; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Sheraz M; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., McGovern-Gooch K; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Xu F; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Fan KY; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Nguyen D; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Kultgen SG; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Lindstrom A; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Stever K; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Tercero B; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Binder RJ; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Liu F; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Micolochick Steuer HM; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Mani N; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Harasym TO; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Thi EP; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Cuconati A; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Dorsey BD; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Cole AG; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Lam AM; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Sofia MJ; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States.
Publikováno v: ACS infectious diseases [ACS Infect Dis] 2024 May 10; Vol. 10 (5), pp. 1780-1792. Date of Electronic Publication: 2024 Apr 23.
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9
Akademický článek
Preclinical Antiviral and Safety Profiling of the HBV RNA Destabilizer AB-161.
Autor: Lam AM; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA., Dugyala RR; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA., Sheraz M; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA., Liu F; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA., Thi EP; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA., Graves IE; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA., Cuconati A; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA., Steuer HM; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA., Ardzinski A; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA., Overholt N; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA., Mason JD; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA., Gotchev D; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA., Cole AG; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA., Harasym TO; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA., Sofia MJ; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA.
Publikováno v: Viruses [Viruses] 2024 Feb 21; Vol. 16 (3). Date of Electronic Publication: 2024 Feb 21.
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10
Akademický článek
Structure-Activity Relationships and Discovery of ( S )-6-Isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydro-6 H -pyrido[1,2- h ][1,7]naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer.
Autor: Gotchev D; Arbutus Biopharma, 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Dorsey BD; Arbutus Biopharma, 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Nguyen D; Arbutus Biopharma, 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Kakarla R; Arbutus Biopharma, 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Dugan B; Arbutus Biopharma, 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Chen S; Arbutus Biopharma, 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Gao M; Arbutus Biopharma, 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Bailey L; Arbutus Biopharma, 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Liu F; Arbutus Biopharma, 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Harasym T; Arbutus Biopharma, 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Chiu T; Arbutus Biopharma, 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Tang S; Arbutus Biopharma, 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Lee AC; Arbutus Biopharma, 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Cole AG; Arbutus Biopharma, 701 Veterans Circle, Warminster, Pennsylvania 18974, United States., Sofia MJ; Arbutus Biopharma, 701 Veterans Circle, Warminster, Pennsylvania 18974, United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Jan 25; Vol. 67 (2), pp. 1421-1446. Date of Electronic Publication: 2024 Jan 08.
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